Abnormalities in cytokine secretion from mesenchymal stem cells in psoriatic skin lesions

Liu, Ruifeng; Yang, Yaru; Yan, Xin; Zhang, Kaiming

doi:10.1684/ejd.2013.2149

Cited by 33 publications

(35 citation statements)

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Section: Introductionsupporting

confidence: 59%

“…Recently, we have performed gene expression profiling, phenotypic, and functional studies on MSCs from patients with psoriasis in vitro . Our experiments preliminarily revealed that bone marrow MSCs derived from patients with psoriasis secreted increased levels of cytokines, such as stem cell factor, granulocyte colony‐stimulating factor, and IL‐6 and decreased levels of TNF‐ α , IL‐1, IL‐3, leukemia inhibitory factor, hepatocyte growth factor, and platelet‐derived growth factor, which confirm the immunomodulatory effects of bone marrow MSCs. Based on our previous microarray analysis, platelet endothelial cell adhesion molecule‐1 ( PECAM1 ), facio‐genital dysplasia‐5 ( FGD5 ), prostaglandin–endoperoxide synthase‐1 ( PTGS1 ), melanoma cell adhesion molecule ( MCAM ), vasohibin‐2 ( VASH 2), and stabilin‐1 ( STAB 1 ) were significantly decreased in psoriatic DMSCs (data were deposited under NCBI GEO GSE42632).…”

Section: Introductionsupporting

confidence: 59%

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Expression of pro‐angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis

et al. 2016

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Section: Introductionsupporting

confidence: 59%

Section: Introductionsupporting

confidence: 59%

Expression of pro‐angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis

et al. 2016

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“…Skin MSCs (S‐MSCs), as an important part of the skin microenvironment, play an important role in regulating local immunity by secreting cytokines, among other mechanisms . Our previous studies revealed that MSCs in patients with psoriasis behave abnormally in terms of DNA methylation, cytokine secretion and immunomodulation . Therefore, we speculated that S‐MSCs in psoriatic lesions play an important role in the local immune abnormality of these lesions.…”

Section: Introductionmentioning

confidence: 99%

Mesenchymal stem cells in psoriatic lesions affect the skin microenvironment through circular RNA

Liu

Chang

et al. 2019

Experimental Dermatology

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Psoriasis is an autoimmune skin disease. Our previous studies revealed abnormal immune regulation of skin mesenchymal stem cells (S‐MSCs) in psoriatic lesions. Circular RNA (circRNA) molecules were recently discovered as a new class of non‐coding regulatory RNAs. Their role in the pathogenesis of psoriasis has not yet been studied. To explore potential circRNA‐mediated mechanisms of S‐MSCs in the pathogenesis of psoriasis, we sequenced mRNAs and circRNAs of MSCs from normal skin and psoriatic lesions, followed by functional prediction and interaction analyses. In total, 129 circRNAs were differentially expressed, including 123 up‐regulated and 6 down‐regulated circRNAs, in MSCs from psoriatic lesions. Pathway analysis showed that the genes significantly down‐regulated in psoriatic as compared to normal S‐MSCs were mainly involved in JAK‐STAT signalling. According to a circRNA‐miRNA‐mRNA interaction network, the expression of circRNAs associated with these mRNAs was also down‐regulated in MSCs of psoriatic skin lesions. Knockdown of the circRNA gene chr2:206992521|206994966 reduced the capacity of S‐MSCs to inhibit T‐cell proliferation upon co‐culture in normal as well as lesion‐derived S‐MSCs. Secreted‐cytokine profiles (IL‐6, IL‐11 and hepatocyte growth factor) were also similar in normal and lesion‐derived S‐MSCs after circRNA knockdown. Thus, the circRNA chr2:206992521|206994966 in S‐MSCs from psoriatic lesions affects the activity of T lymphocytes in local lesions by influencing their cytokine secretion. Taken together, our findings indicate that circRNA mediates the role of S‐MSCs in the pathogenesis of psoriasis.

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“…found that MSCs obtained from psoriatic skin lesions had decreased inhibitory effect on T‐cell proliferation and concluded that abnormal MSCs may contribute to the pathogenesis of psoriasis. BMSCs and resident skin MSCs of psoriatic patients have also been shown to have abnormal cytokine secretion, favouring the production of Th‐1 and Th‐17 cytokines . Replacing the abnormal endogenous MSCs with allogeneic exogenous MSCs from healthy donors may benefit psoriatic patients in future studies.…”

Section: Clinical Use Of Mscs In Dermatologymentioning

confidence: 99%

“…BMSCs and resident skin MSCs of psoriatic patients have also been shown to have abnormal cytokine secretion, favouring the production of Th-1 and Th-17 cytokines. 75,76 Replacing the abnormal endogenous MSCs with allogeneic exogenous MSCs from healthy donors may benefit psoriatic patients in future studies. Notwithstanding, the microenvironment of the psoriatic skin could also induce transplanted MSCs to behave abnormally, ameliorating any potential beneficial effects.…”

Section: Psoriasismentioning

confidence: 99%

Mesenchymal stromal cells: properties and role in management of cutaneous diseases

Kim

Blasco‐Morente

Cuende

et al. 2016

Acad Dermatol Venereol

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This review describes the current understanding and the potential use of mesenchymal stromal cells (MSCs) in cell-based therapies for clinical management of difficult wounds and other dermatoses. MSCs have been shown to possess many advantageous properties that make them a promising therapeutic modality in dermatology still under investigation. In fact, MSCs' ability to promote wound healing through its paracrine function and pro-angiogenic properties have generated increasing interest for treating acute and chronic wounds. There is also great interest in utilizing MSCs' immunological characteristics for therapeutic use especially for patients with debilitating systemic autoimmune and inflammatory skin conditions who have failed other therapies. Its role in aesthetics has also been explored with clinical data showing improvement of acne scars and wrinkles from photoaging. Clinical trials are underway investigating the safety and efficacy of MSCs in the treatment of different skin conditions such as acute burns, diabetic and venous stasis ulcers, epidermolysis bullosa and systemic sclerosis, among others. We anticipate that as our understanding of the characteristics and function of MSCs grow, so will its role in cell-based treatments of dermatological conditions.

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Abnormalities in cytokine secretion from mesenchymal stem cells in psoriatic skin lesions

Cited by 33 publications

References 0 publications

Expression of pro‐angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis

Expression of pro‐angiogenic genes in mesenchymal stem cells derived from dermis of patients with psoriasis

Mesenchymal stem cells in psoriatic lesions affect the skin microenvironment through circular RNA

Mesenchymal stromal cells: properties and role in management of cutaneous diseases

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