Abnormal Whole-Body and Cellular (Erythrocytes) Turnover of 22Na+ in Normotensive Relatives of Probands with Established Essential Hypertension

Henningsen, N. C.; Mattsson, Sören; Nosslin, B; Nelson, Dick; Ohlsson, Ola

doi:10.1042/cs057321s

Cited by 41 publications

(7 citation statements)

References 10 publications

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“…Alterations in red cell Na-K cotransport, sodium permeability, total sodium efflux, and sodium influx in hypertensives have all been described."" 14 Additional investigators have worked with leucocytes. 29 " 31 Contradictory findings have been reported and the relationships among various assays are unclear.…”

Section: Discussionmentioning

confidence: 99%

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Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.

Trevisan

Ostrow²,

Cooper³

et al. 1983

Hypertension

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SUMMARY A population-based survey of 134 white men, recruited from the Chicago People's Gas Company labor force, was carried out to examine the association between sodium-lithium (Na-Li) countertransport and hypertension. Of the 134 participants in this industry-sponsored periodic health examination, 64 were normotensive and 70 were either taking antihypertensive medications or had a systolic pressure 3= 140 or a diastolic pressure 2= 90 mm Hg. The hypertensives were older and more overweight. Countertransport was significantly higher in hypertensives than in normotensives. Among the three subgroups of hypertensives -untreated borderline (140/90 to 160/95 mm Hg), untreated definite (over 160/95 mm Hg), and treated -an increase in countertransport was consistently observed, significant for the latter two groups. The relationship between countertransport and hypertension was independent of overweight, with countertransport being significantly related to both blood pressure and overweight. Altered ion transport may play an important role in the etiology and/or pathophysiology of hypertension. (Hypertension 5:363-367, 1983) KEY WORDS • countertransport • sodium metabolism • blood pressure R ED blood cell sodium-dependent membrane processes are currently being studied in relation to the etiology and pathogenesis of hypertension. 1 " 14 Previous case control studies have demonstrated a relationship between sodium-lithium (Na-Li) countertransport and hypertension.'-7 -15~17 This report described the results of a populationbased cross-sectional survey in employed white men relating levels of countertransport to the presence of hypertension. Methods Data CollectionVolunteers for this study were male employees (the great majority of whom were white) of the Chicago People's Gas Company participating in the companysponsored periodic health examination. The participation rate in this examination is over 90%. l8 During the period from June 1981 to December 1981, on a semi weekly basis, without selection the first four employees who presented at the company medical office for their regularly scheduled examination were invited to participate; response rate was 100%.A nurse measured blood pressure after the man had rested quietly in the sitting position for 5 minutes. Korotkoff sounds phases I and V were recorded from a single reading with a standard mercury sphygmomanometer. While blood was being sampled for routine laboratory analyses, an additional 15 cc of venous blood was collected in plastic tubes containing ammonium heparin. Samples were collected in the fasting state before 10 a.m. With the man in indoor clothes, with shoes off, height and weight were measured on a balance scale. Medical history was obtained through the use of a self-administered questionnaire.Of 157 white men participating in the study, 21 were excluded from this report because of a major illness (renal, hormonal, psychiatric) thought to influence intracellular ion metabolism. 6 l9 -2I In addition, two participants were excluded because of extremely...

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Section: Discussionmentioning

confidence: 99%

“…1 " 14 Previous case control studies have demonstrated a relationship between sodium-lithium (Na-Li) countertransport and hypertension. '-7 -15~17 This report described the results of a populationbased cross-sectional survey in employed white men relating levels of countertransport to the presence of hypertension.…”

mentioning

confidence: 99%

Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.

Trevisan

Ostrow²,

Cooper³

et al. 1983

Hypertension

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“…(29) and Henningsen et al (15) show an increased erythrocyte sodium level in hypertensive patients and their normotensive relatives. Potassium levels are presumably altered concomitantly, since the intracellular contents of sodium and potassium are closely related by the active alkali cation transport system and the diffusion along the ion gradient (5).…”

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confidence: 95%

Erythrocyte and Total Body Potassium in Untreated Primary Hypertension

Ericsson

Carlmark

Eliasson

1981

Journal of Internal Medicine

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ABSTRACT. In a study of total body and erythrocyte potassium in mild hypertension we found decreased intracellular potassium concentrations in 41 hypertensives compared to controls but no correlation between intracellular potassium, measured by whole body counting, and erythrocyte potassium. A total body potassium corresponding to an intracellular potassium of 85% or less of the expected value was found in 44 % of the patients, the decrease being more marked in females. In the hypertensives, a negative correlation existed between serum and erythrocyte potassium. No correlation was found between potassium decrease and urinary aldosterone or plasma renin level. An inhibition of the active sodium‐potassium exchange at the cellular level is proposed as an explanation of these findings.

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“…Lately, research on the cellular effects of the sodium ion (5)(6)(7)(8)(9) and the influence of salt intake on the activity and effects of the sympathetic nervous system (10,11) has again increased interest in the role of sodium in the regulation of the blood pressure and in the development of essential hypertension.…”

Section: Introductionmentioning

confidence: 99%

The role of salt in hypertension

Berglund

1983

Journal of Internal Medicine

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Epidemiological data indicate a weak but significant positive correlation between the level of salt intake and blood pressure. It is unclear how this relationship is mediated but some studies indicate that heredity for hypertension is associated with an increased sensitivity to salt. Decrease of the salt intake decreases blood pressure in established hypertension and should be used as a therapeutic adjuvant in mild uncomplicated hypertension much more often than is now the case. Increased salt intake in young subjects with or without heredity for hypertension does not seem to increase the blood pressure during a 4–12 week load. Increased salt intake in middle‐aged men, on the other hand, seem to induce a blood pressure increase irrespective of the presence or absence of a positive family history. The sensitivity to a high salt intake might thus be associated with aging. Increase of the salt intake from the normal level seems to induce an increase in sympathetic nervous activity. The interplay between the level of salt intake and sympathetic nervous activity should be studied in more detail.

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Abnormal Whole-Body and Cellular (Erythrocytes) Turnover of 22Na+ in Normotensive Relatives of Probands with Established Essential Hypertension

Cited by 41 publications

References 10 publications

Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.

Abnormal red blood cell ion transport and hypertension. The People's Gas Company study.

Erythrocyte and Total Body Potassium in Untreated Primary Hypertension

The role of salt in hypertension

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