Abnormal white matter integrity in synthetic cannabinoid users

Zorlu, Nabi; Biase, Maria A Di; Kalayci, Cigdem Colak; Zalesky, Andrew; Bağcı, Başak; Oğuz, Nihan; Gelal, Fazıl; Beşiroğlu, Lütfullah; Gülseren, Şeref; Sarıçiçek, Aybala; Bora, Emre; Pantelis, Christos

doi:10.1016/j.euroneuro.2016.08.015

Cited by 24 publications

(19 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This in turn is thought to lead to overactivation of dopaminergic activity in the prefrontal cortex, resulting in psychotic symptoms (Bossong and Niesink, 2010). Additionally, a recent MRI study suggests that long term use of SCRAs is associated with abnormal white matter integrity, which has also been proposed as a theory for the mechanism of vulnerability to psychosis (Zorlu et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Spicing it up - synthetic cannabinoid receptor agonists and psychosis - a systematic review

Hobbs

Kalk

Morrison

et al. 2018

European Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Spicing it up - synthetic cannabinoid receptor agonists and psychosis - a systematic review

Hobbs

Kalk

Morrison

et al. 2018

European Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Although, to date, no study has investigated cognitive deficits in synthetic cannabinoid users, a recently published study showed that long‐term use (more than five times a week for at least 1 year) of synthetic cannabinoids was associated with white matter abnormalities in adolescents and young adults (Zorlu et al , ). Disturbed brain connectivity in synthetic cannabinoid users may underlie cognitive impairment, particularly as synthetic cannabinoid intake has been associated with psychosis (Papanti et al , ).…”

Section: Novel Psychoactive Substancesmentioning

confidence: 99%

Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure

d'Angelo

Savulich

Sahakian

2017

British J Pharmacology

View full text Add to dashboard Cite

Today, there is continued, and in some cases growing, availability of not only psychoactive substances, including treatments for mental health disorders such as cognitive enhancers, which can enhance or restore brain function, but also ‘recreational’ drugs such as novel psychoactive substances (NPS). The use of psychoactive drugs has both benefits and risks: whilst new drugs to treat cognitive symptoms in neuropsychiatric or neurodegenerative disorders could have great benefits for many patient groups, the increasing ease of accessibility to recreational NPS and the increasing lifestyle use of cognitive enhancers by healthy people means that the effective management of psychoactive substances will be an issue of increasing importance. Clearly, the potential benefits of cognitive enhancers are large and increasingly relevant, particularly as the population ages, and for this reason, we should continue to devote resources to the development of cognitive enhancers as treatments for neurodegenerative diseases and psychiatric disorders, including Alzheimer's disease, attention deficit hyperactivity disorder and schizophrenia. However, the increasing use of cognitive enhancers by healthy individuals raises safety, ethical and regulatory concerns, which should not be ignored. Similarly, understanding the short‐ and long‐term consequences of the use of NPS, as well as better understanding the motivations and profiles of users could promote more effective prevention and harm reduction measures. Linked ArticlesThis article is part of a themed section on Pharmacology of Cognition: a Panacea for Neuropsychiatric Disease? To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v174.19/issuetoc

show abstract

“…SK'ların akut ve kronik dönemde psikomotor becerileri etkileyip etkilemediğini gösteren kontrollü çalışmalar henüz yeterli sayıda bulunmamaktadır. JWH-018, AM-2201, JWH-210, JWH-122 maruziyeti sonrası sürücülük becerilerinin ölçüldüğü bir çalışmada SK' kullanıcılarının sağlıklı kontrollere göre psikomotor becerilerinin daha düşük olduğu saptanmış olup, çalışmadaki örneklem sayısı sonuçların genellenebilirliği için oldukça düşüktür 27 Baş dönmesi 77 Kronik SSS'de yapısal ve işlevsel bozumlara ait bulgular 42,56 Hipokampus ve amigdalada yapısal ve işlevsel değişiklikler 53,54 saptanmıştır 28 . Sürücüler ile yapılan başka bir çalışmaya göre de bir SK türevi olan UR-144'ün esrara göre psikomotor becerileri ve sürücü performansını daha olumsuz etkilediği bildirilmiştir 29 .…”

Section: Psikomotor Becerilerunclassified

“…tarafından DTI kullanılarak yapılan bir çalışmada haftada 5'ten fazla 1 yıllık SK kullanımı olan 22 kişilik ergen ve genç erişkin, 18 kişilik sağlıklı kontrol grubu ile karşılaştırılmış ve SK kullanımı olan grupta sol temporal lob, sol fornix, sol cingulum ve sol kortikopsinal traktta beyaz cevherde incelme tespit edilmiştir56 . Kortikospinal traktta beyaz cevherdeki incelmenin SK'ya bağlı ani ölümleri açıklayabileceği düşünülmektedir56 . Diğer alanlardaki incelmenin piskoza yatkınlık ve bilişsel bozulma ile ilişkili olabileceği düşünülmüştür56 .…”

unclassified

See 1 more Smart Citation

Sentetik Kannabinoidlerin Nöropsikiyatrik Etkileri

Aral

Avcı

Usta

2020

Arşiv Kaynak Tarama Dergisi

View full text Add to dashboard Cite

Synthetic cannabinoids are common names of many compounds produced in a laboratory environment that mimic the psychoactive effects of cannabis. The use of synthetic cannabinoid is a public health problem that has become widespread among young people in recent years. Due to the increasing rate of usage, there are many studies needed to better understand the effects, reduce the consumption rate and facilitate the elimination of the negative effects it creates. Knowing the neuropsychiatric conditions that may occur as a result of the use of synthetic cannabinoids and distinguishing them from cannabis use will guide the arrangements to improve the functionality of the neurorehabilitation process.

show abstract

Abnormal white matter integrity in synthetic cannabinoid users

Cited by 24 publications

References 67 publications

Spicing it up - synthetic cannabinoid receptor agonists and psychosis - a systematic review

Spicing it up - synthetic cannabinoid receptor agonists and psychosis - a systematic review

Lifestyle use of drugs by healthy people for enhancing cognition, creativity, motivation and pleasure

Sentetik Kannabinoidlerin Nöropsikiyatrik Etkileri

Contact Info

Product

Resources

About