Abnormal white matter integrity as a structural endophenotype for bipolar disorder

Sarıçiçek, Aybala; Zorlu, Nabi; Yalın, Nefize; Hıdıroğlu, Ceren; Çavuşoğlu, Berrin; Ceylan, Deniz; Ada, Emel; Tunca, Zeliha; Özerdem, Ayşegül

doi:10.1017/s0033291716000180

Cited by 44 publications

(37 citation statements)

References 81 publications

(101 reference statements)

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“…Interestingly, our results indicated significant differences in the FA values in the UF in female patients with BD aged 26–45 years, suggesting that the structural integrity of this neural circuit is impaired in female patients with BD during adulthood. This is consistent with the results of previous structural studies that included both adult men and women and reported significantly decreased FA in BD patients during adulthood compared with the control group [ 9 , 34 , 36 , 37 , 55 ]. In contrast, other studies have shown that adult patients with BD exhibit significantly increased FA compared with healthy controls in the left UF [ 32 , 33 ].…”

Section: Discussionsupporting

confidence: 92%

Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

Tang

Fan

et al. 2018

BMC Psychiatry

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BackgroundBipolar disorder (BD) is a serious mental illness. Several studies have shown that brain structure and function changes and the development of BD are associated with age and sex differences. Therefore, we hypothesized that the functional and structural neural circuitry of BD patients would differ according to age. The amygdala and prefrontal cortex (PFC) are play a key role in the emotional and cognitive processing of patients with BD. In this study, we used magnetic resonance imaging (MRI) to examine the structural and functional connectivity within amygdala-PFC neural circuitry in women with BD at different ages.MethodsForty-nine female patients with BD who were aged 13–25 years and 60 age-matched healthy control (HC) individuals, as well as 43 female patients with BD who were aged 26–45 years and 60 age-matched HC individuals underwent resting-state functional MRI (rs-fMRI) and diffusion tensor imaging to examine the structural and functional connectivity within the amygdala-PFC neural circuitry.ResultsWe found abnormalities in the amygdala-PFC functional connectivity in patients aged 13–25 years and significantly different fractional anisotropy (FA) values in patients aged 26–45 compared with the age-matched HCs. The significance of these findings was indicated by corrected p values of less than 0.05 (uncorrected p values less than 0.001).ConclusionsThe findings in this cross-sectional study suggested that abnormalities in the functional connectivity of the amygdala-PFC neural circuitry are related to the pathophysiology of BD in women aged 13–25 years, while changes in the structural integrity of this neural circuitry are associated with the pathophysiology of BD in women aged 26–45 years. Therefore, functional and structural brain alterations may occur at different ages in female patients with BD.Electronic supplementary materialThe online version of this article (10.1186/s12888-018-1732-9) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 92%

Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

Tang

Fan

et al. 2018

BMC Psychiatry

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“…As detected by brain MRI ( fig.2 ), our patient's lesions were located in the left temporal and parietal lobes, which may account for her obvious auditory hallucinations in the early stage. It has been proven that cortical and subcortical white matter lesions gave rise to psychiatric symptoms by impeding the white matter pathways and interfering with equilibrium of neurotransmitter adjustment [35] , [36] , [37] , [38] . Moreover, whether hypothyroidism gave rise to the psychiatric symptoms is uncertain [39] , [40] .…”

Section: Discussionmentioning

confidence: 99%

Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders

Shang

Chen

et al. 2017

eNeurologicalSci

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Mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a clinical syndrome associated with mitochondrial disorders (MIDs). This report illustrates a case of MELAS syndrome with hypothyroidism and psychiatric disorders, which is different from the common clinical manifestations of MELAS syndrome, such as exercise intolerance, migraine-like headaches, hearing loss and seizures etc. There are considerable interests in the possibility that mitochondrial dysfunction may play a role in the pathogenesis of endocrine dysfunctions and psychiatric disorders in MELAS syndrome.

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“…Many studies have attempted to identify trait and state markers of a range of psychiatric disorders, including anorexia nervosa (AN), 9–12 depression, 13 bipolar disorder, 14 and schizophrenia. 15 A trait marker of a disorder is typically conceptualized in these studies as a characteristic that distinguishes an individual with a disorder from healthy controls, is present before and predicts disorder onset, persists following total or partial remission, and is present in individuals with subclinical profiles.…”

Section: Introductionmentioning

confidence: 99%

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

Cyr

Kopala‐Sibley

Lee

et al. 2017

Journal of the American Academy of Child & Adolescent Psych

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Objective Cross-sectional data suggest functional and anatomical disturbances in inferior and orbital frontal regions in bulimia nervosa (BN). Using longitudinal data, we investigated whether reduced cortical thickness (CT) in these regions arises early and persists over adolescence in BN, independent of symptom remission, and whether CT reductions are markers of BN symptoms. Method Thirty-three adolescent females with BN symptoms (BN or other specified feeding or eating disorder) and 28 healthy adolescents participated in this study. Anatomical magnetic resonance imaging and clinical data were acquired at three time points within 2-year intervals over adolescence with 31% average attrition between assessments. Using a region-of-interest approach, we assessed group differences in CT at baseline and over time, and tested whether between- and within-subject variations in CT were associated with the frequency of BN symptoms. Results Reduced CT in right inferior frontal gyrus persisted over adolescence in BN compared to healthy adolescents, even in those who achieved full or partial remission. Within the BN group, between-subject variations in CT in inferior and orbital frontal regions were inversely associated with specific BN symptoms, suggesting, on average over time, greater CT reductions in those with more frequent BN symptoms. Conclusion Reduced CT in inferior frontal regions may contribute to illness persistence into adulthood. Reductions in the thickness of inferior and orbital frontal regions may be markers of specific BN symptoms. Since our sample size precluded correcting for multiple comparisons, these findings should be replicated in a larger sample. Future study of functional changes in associated fronto-striatal circuits could identify potential circuit-based intervention targets.

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Abnormal white matter integrity as a structural endophenotype for bipolar disorder

Abstract: Decreased FA in the fornix, left posterior thalamic radiation and left sagittal stratum in both bipolar patients and unaffected siblings may represent a potential structural endophenotype or a trait-based marker for BD.

Cited by 44 publications

References 81 publications

Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder

Adult-onset of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome with hypothyroidism and psychiatric disorders

Reduced Inferior and Orbital Frontal Thickness in Adolescent Bulimia Nervosa Persists Over Two-Year Follow-Up

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