Abnormal white matter integrity and decision-making deficits in alcohol dependence

Zorlu, Nabi; Gelal, Fazıl; Kuserli, Ali; Cenik, Ebuzer; Durmaz, Ercan; Sarıçiçek, Aybala; Gülseren, Şeref

doi:10.1016/j.pscychresns.2013.06.014

Cited by 43 publications

(43 citation statements)

References 52 publications

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“…Based on RD and AD measurements, the FA difference between the groups was driven by lower RD, indicating demyelination in ADPs. Our findings were also consistent with previous studies in alcohol dependence [46, 47]. The myelin abnormalities in patients might be explained by following factors: direct neurotoxic effects of alcohol, vitamin deficiency or genetic predisposition [47, 48].…”

Section: Discussionsupporting

confidence: 93%

“…Our findings were also consistent with previous studies in alcohol dependence [46, 47]. The myelin abnormalities in patients might be explained by following factors: direct neurotoxic effects of alcohol, vitamin deficiency or genetic predisposition [47, 48]. Along with the GM deficits in ADPs, it was obvious to notice these abnormal WM regions just connected the damaged GM areas in ADPs.…”

Section: Discussionsupporting

confidence: 92%

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Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity

et al. 2016

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BackgroundPrevious studies have documented that heightened impulsivity likely contributes to the development and maintenance of alcohol use disorders. However, there is still a lack of studies that comprehensively detected the brain changes associated with abnormal impulsivity in alcohol addicts. This study was designed to investigate the alterations in brain structure and functional connectivity associated with abnormal impulsivity in alcohol dependent patients.MethodsBrain structural and functional magnetic resonance imaging data as well as impulsive behavior data were collected from 20 alcohol dependent patients and 20 age- and sex-matched healthy controls respectively. Voxel-based morphometry was used to investigate the differences of grey matter volume, and tract-based spatial statistics was used to detect abnormal white matter regions between alcohol dependent patients and healthy controls. The alterations in resting-state functional connectivity in alcohol dependent patients were examined using selected brain areas with gray matter deficits as seed regions.ResultsCompared with healthy controls, alcohol dependent patients had significantly reduced gray matter volume in the mesocorticolimbic system including the dorsal posterior cingulate cortex, the dorsal anterior cingulate cortex, the medial prefrontal cortex, the orbitofrontal cortex and the putamen, decreased fractional anisotropy in the regions connecting the damaged grey matter areas driven by higher radial diffusivity value in the same areas and decreased resting-state functional connectivity within the reward network. Moreover, the gray matter volume of the left medial prefrontal cortex exhibited negative correlations with various impulse indices.ConclusionsThese findings suggest that chronic alcohol dependence could cause a complex neural changes linked to abnormal impulsivity.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity

et al. 2016

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“…Gray matter volume within the occipital cortex was positively correlated with the video gaming addiction score and the amount of lifetime video gaming (Kuhn & Gallinat, 2014). Also, riskier performance in the Iowa Gambling Task was related to reduced occipital WM integrity in alcohol-dependent subjects (Zorlu et al, 2013). It is plausible to postulate that, as a visual information transferring tract, the right occipital subcortical WM may have potential microstructural changes in the IGD adolescents which contributed to the altered correlation between impulsivity and the FA values.…”

Section: T a B L Ementioning

confidence: 95%

Diffusion tensor imaging of the structural integrity of white matter correlates with impulsivity in adolescents with internet gaming disorder

Liu

Yang

et al. 2017

Brain and Behavior

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“…Impairments on the Iowa Gambling task are linked to lower fractional anisotropy (FA), an index of white-matter integrity, of the superior longitudinal fasciculus, corticospinal tract, and superior corona radiata in cocaine-dependent participants (Lane, Steinberg et al 2010), and in frontal, parietal, occipital, and callosal regions across samples of healthy and alcohol-dependent participants (Zorlu et al, 2013). These studies have begun to detail the importance of white-matter integrity in reward-based risky decision-making, but the links between structural connectivity and functional brain activation have not been directly examined.…”

Section: Introductionmentioning

confidence: 99%

A neural network that links brain function, white-matter structure and risky behavior

et al. 2017

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The ability to evaluate the balance between risk and reward and to adjust behavior accordingly is fundamental to adaptive decision-making. Although brain-imaging studies consistently have shown involvement of the dorsolateral prefrontal cortex, anterior insula and striatum during risky decision-making, activation in a neural network formed by these regions has not been linked to structural connectivity. Therefore, in this study, white-matter connectivity was measured with diffusion-weighted imaging in 40 healthy research participants who performed the Balloon Analogue Risk Task, a test of risky decision-making, during fMRI. Fractional anisotropy within a network that includes white-matter pathways connecting four regions (the prefrontal cortex, insula and midbrain to the striatum) was positively correlated with the number of risky choices and total amount earned on the task, and with the parametric modulation of activation in regions within the network to the level of risk during choice selection. Furthermore, analysis using a mixed model demonstrated how relationships of the parametric modulation of activation in each of the four aforementioned regions are related to risk probabilities, and how previous trial outcomes and task progression influence the choice to take risk. The present findings provide the first direct evidence that white-matter integrity is linked to function within previously identified components of a network that is activated during risky decision-making, and demonstrate that the integrity of white-matter tracts is critical in consolidating and processing signals between cortical and striatal circuits during the decision-making process.

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Abnormal white matter integrity and decision-making deficits in alcohol dependence

Cited by 43 publications

References 52 publications

Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity

Alterations in Brain Structure and Functional Connectivity in Alcohol Dependent Patients and Possible Association with Impulsivity

Diffusion tensor imaging of the structural integrity of white matter correlates with impulsivity in adolescents with internet gaming disorder

A neural network that links brain function, white-matter structure and risky behavior

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