Abnormal weight gain in rats with amygdaloid lesions

King, Bruce M.; Kass, Jenny M.; Neville, Katherine L.; Sam, Hoan; Tatford, Archie C; Zansler, Cari A.

doi:10.1016/0031-9384(93)90237-a

Cited by 50 publications

(11 citation statements)

References 25 publications

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“…The results of the present study confirm our earlier reports of excessive weight gains after electrolytic lesions of the most posterodorsal aspects of the amygdala in rats (50,51,84). Mean daily weight gains ranged from 10.6 to 16.2 g in the first 2-3 days after lesions.…”

Section: Body Weightsupporting

confidence: 93%

“…111), a minimum criterion for weight gain of 10 g/day was used to select animals with bilateral lesions for inclusion in the group to be processed for silver staining. Ten grams per day is at the high end of weight gain in the first few days after PDA lesions (50,51). Animals with unilateral or control lesions were not screened according to this weight gain criterion.…”

Section: Body Weightmentioning

confidence: 99%

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Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

King

Cook

Rossiter

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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King, Bruce M., Jack T. Cook, Kirk N. Rossiter, and Bethany L. Rollins. Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport. Am J Physiol Regul Integr Comp Physiol 284: R965-R982, 2003. First published November 14, 2002 10.1152/ajpregu.00249.2002.-Small lesions centered in the posterodorsal region of the medial amygdala resulted in excessive weight gains in female rats. Unilateral lesions were nearly as effective as bilateral lesions in the first 48 h after surgery (ϩ21 to ϩ32 g). Assessment of lesion damage was done by both qualitative evaluation and by a quantitative grid-point counting method. The critical sites for weight gain were the intra-amygdaloid bed nucleus of the stria terminalis and the posterodorsal medial amygdaloid nucleus. Incidental damage to the overlying globus pallidus was negatively related to weight gain. The cupric silver method for demonstrating axonal degeneration was applied to brains with obesity-inducing lesions. A dense pattern of degenerating terminals was found in the lateral septum, amygdala, ventral striatum, and ventromedial hypothalamus. Degeneration in the paraventricular nucleus of the hypothalamus was scarce or absent. Small retrograde tracer injections made in either the intra-amygdaloid bed nucleus of the stria terminalis or in the posterodorsal medial amygdaloid nucleus labeled cells in the amygdala, lateral septum, and hypothalamus, reciprocating the anterograde projections from the amygdala to these areas. The data suggest that subdivisions of the posterodorsal amygdala participate in the regulation of feeding in a manner that is similar to the better-known role of this part of the brain in mediating reproductive behavior. Although topographical differences may exist within the amygdaloid and hypothalamic subdivisions regulating these two sexually dimorphic behaviors, the relays engaged by feeding-related connections and those related to reproduction are remarkably parallel. nucleus accumbens; hypothalamus; stria terminalis SEVERAL RECENT STUDIES have demonstrated that bilateral electrolytic lesions of the amygdala in female rats can result in marked hyperphagia and excessive weight gains. Daily food intake nearly doubles, and weight gains of 20-30 g during the first 3 days after lesions are not unusual (e.g., 45, 50-53, 84). Weight gains of Ն100 g in 20-25 days have been observed (50, 51). The lesions result in a marked preference for carbohydrates (53). Although food intake eventually returns to normal, the excessive weight gain is maintained indefinitely, with a marked increase in adipose tissue (50).These results are similar to those reported many years ago for cats, dogs, and primates (including humans) given amygdaloid lesions or temporal lobectomies (e.g., 9, 32, 37, 70, 103). In the rat, the effective lesion site for hyperphagia and obesity has recently been identified as the posterodorsal part of the medial amygdaloid nucleus (MePD) and the intra-amygdaloid bed nucleus of the stria terminalis (BSTIA), together ...

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Section: Body Weightsupporting

confidence: 93%

Section: Body Weightmentioning

confidence: 99%

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

King

Cook

Rossiter

et al. 2003

American Journal of Physiology-Regulatory, Integrative and Comp

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“…However, a significant decrease in the levels of RXFP3 receptor protein was observed in the basolateral, central and medial amygdala in young and middle‐aged female rats compared with male rats (Meadows and Byrnes, ). Interestingly, lesions in the posterodorsal aspects of the amygdala resulted in immediate hyperphagia and moderate obesity in female rats (King et al , ; King et al , ). Food intake returned to normal levels within a few days after the lesion procedure, but the excessive weight gain (King et al , ) and preference for a high‐carbohydrate diet (King et al , ) persisted after inactivation of the amygdala in female rats.…”

Section: Introductionmentioning

confidence: 99%

Sex‐specific effects of relaxin‐3 on food intake and body weight gain

Calvez

Ávila

Timofeeva

2016

British J Pharmacology

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“…In the 1990s, King and colleagues began to reexamine the effects of small lesions placed throughout the amygdala and adjacent temporal lobe structures in female rats. Bilateral lesions centered in the posterodorsal amygdala (PDA) resulted in marked hyperphagia (usually lasting 10 -15 days) and excessive weight gains (92,99,100,105,181). Female rats with PDA lesions fed a standard laboratory chow diet typically gained 50 -80 g in 20 days (compared with typical weight changes of Ϫ10 to ϩ15 g for control animals), with weight gains of 100 g occasionally being observed (92,93,95,99,100).…”

Section: Lesion Studies With Ratsmentioning

confidence: 99%

Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus

King¹

2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Lesions of the amygdala have long been known to produce hyperphagia and obesity in cats, dogs, and monkeys, but only recently have studies with rats determined that the effective site is the posterodorsal amygdala (PDA)-the posterodorsal medial amygdaloid nucleus and the intra-amygdaloid bed nucleus of the stria terminalis. There is a sex difference; female rats with PDA lesions display greater weight gain than male rats. In the brains of female rats with obesity-inducing PDA lesions, there is a dense pattern of axonal degeneration in the capsule of the ventromedial hypothalamus (VMH) and other targets of the stria terminalis. Transections of the dorsal component of the stria terminalis also result in hyperphagia and obesity in female rats. Similar to rats with VMH lesions, rats with PDA lesions are hyperinsulinemic during food restriction and greatly prefer high-carbohydrate diets. The PDA is also a critical site for some aspects of rodent sexual behavior, particularly those that depend on olfaction, and the pattern of degeneration observed after obesity-inducing PDA lesions is remarkably parallel to the circuit that has been proposed to mediate sexual behavior. Medial amygdaloid lesions disrupt the normal feeding pattern and result in impaired responses to caloric challenges, and there is evidence that these behavioral changes are also due to a disruption of olfactory input. With its input from the olfactory bulbs and connections to the VMH, the PDA may be a nodal point at which olfactory and neuroendocrine stimuli are integrated to affect feeding behavior.

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Abnormal weight gain in rats with amygdaloid lesions

Cited by 50 publications

References 25 publications

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

Obesity-inducing amygdala lesions: examination of anterograde degeneration and retrograde transport

Sex‐specific effects of relaxin‐3 on food intake and body weight gain

Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus

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