Abnormal Ventral Somatomotor Network Homogeneity in Patients With Temporal Lobe Epilepsy

Abstract

BackgroundAbnormalities of functional connectivity in the somatomotor network have been thought to play an essential role in the pathophysiology of epilepsy. However, there has been no network homogeneity (NH) study about the ventral somatomotor network (VSN) in patients with temporal lobe epilepsy (TLE). Therefore, we explored the NH of the VSN in TLE patients in this study.MethodsThe sample included 52 patients with left temporal lobe epilepsy, 83 patients with right temporal lobe epilepsy, and 68 healthy controls. The NH method was utilized to analyze the resting-state functional magnetic resonance imaging data.ResultsCompared to the controls, rTLE patients had significantly higher NH in the bilateral postcentral gyrus, and significantly lower NH in the bilateral Rolandic operculum and the right superior temporal gyrus (STG). The NH values of the left postcentral gyrus were significantly higher in lTLE patients than in the healthy controls, and lTLE patients had lower NH in the right Rolandic operculum. The altered NH in the postcentral gyrus was negatively correlated with the illness duration, and the decreased NH in the left Rolandic operculum was negatively correlated with the executive control reaction time (ECRT).ConclusionOur findings suggest that altered NH of the postcentral gyrus, Rolandic operculum and STG might be associated with the pathophysiology of TLE, and thus, highlight the contribution of the VSN to the pathophysiology of TLE.

Abnormal Reginal Homogeneity in Left Anterior Cingulum Cortex and Precentral Gyrus as a Potential Neuroimaging Biomarker for First-Episode Major Depressive Disorder

“…The support vector machine (SVM) has solved clinical problems since the mid-nineties. Several studies have used SVM combined with neuroimaging data to explore the diagnosis and treatment response prediction of depression at the individual level to improve the diagnostic accuracy of depression ( 21 – 27 ). By using SVM analysis, the possibility of distinguishing MDD from healthy controls by using the extracted abnormal ReHo values in brain regions can be examined in our study.…”

Abnormal resting-state functional connectivity of hippocampal subregions in children with primary nocturnal enuresis

“…Our results also exhibited reduced RSFC between the left rHipp and some sensorimotor areas, including the right Rolandic operculum and right precentral gyrus. Integrated exteroceptive-interoceptive signals are processed by the Rolandic operculum for bodily self-awareness and interoceptive awareness ( 38 , 39 ). The hippocampus also plays an important role in interoception ( 13 ).…”

Altered voxel-mirrored homotopic connectivity in right temporal lobe epilepsy as measured using resting-state fMRI and support vector machine analyses

“…Progressive advances in neuroimaging techniques have been leveraged to guide the diagnosis of many psychiatric conditions. The change of network homogeneity (NH) is used to explain the aberrant connectivity of the default mode network (DMN) in patients with depression or lTLE ( 21 , 22 ) and also to explain alterations in the dorsal attachment network (DAN) and the ventral attachment network (VAN) in patients with rTLE ( 23 , 24 ). Functional connectivity (FC) is often used as a neuroimaging biomarker when assessing intrahemispheric and interhemispheric salience and auditory network abnormalities in patients with somatization disorders ( 25 ).…”