Abnormal vascular endothelial growth factor protein expression may be correlated with poor prognosis in diffuse large B-cell lymphoma: A meta-analysis

Jiang, Li; Sun, Jiang Hong; Quan, Lina; Tian, Yuzhou; Jia, Chuiming; Liu, Zhiqiang; Liu, Ai-Chun

doi:10.4103/0973-1482.146086

Cited by 8 publications

(3 citation statements)

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“…Our results are in keeping with two recent studies on the prognostic impact of VEGF expression in DLBCL. In a meta-analysis of 8 studies (670 patients), positive VEGF protein expression in blood circulating lymphocytes and lymph nodes correlated with shorter survival in newly diagnosed DLBCL [ 28 ]. In another recent study performed on 149 newly diagnosed DLBCL, high serum VEGF level was associated with poorer prognosis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

VEGF121, is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers

Broséus

Ramstein

Bernard³

et al. 2017

Oncotarget

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Section: Discussionmentioning

confidence: 99%

VEGF121, is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers

Broséus

Ramstein

Bernard³

et al. 2017

Oncotarget

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show abstract

“…In a meta-analysis of eight studies conducted on 670 patients, positive VEGF expression in blood-circulating lymphocytes and lymph nodes correlated with shorter survival in newly diagnosed DLBCL [ 102 ]. In another study performed on 149 newly diagnosed DLBCLs, high serum VEGF level was associated with poorer prognosis [ 103 ].…”

Section: Bridging the Gaps Between Disease Biology And Clinical Trmentioning

confidence: 99%

New Insights into Diffuse Large B-Cell Lymphoma Pathobiology

Solimando

Annese

Tamma

et al. 2020

Cancers

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Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases of NHL. Analysis of the tumor microenvironment is an important aspect of the assessment of the progression of DLBCL. In this review article, we analyzed the role of different cellular components of the tumor microenvironment, including mast cells, macrophages, and lymphocytes, in the tumor progression of DLBCL. We examined several approaches to confront the available pieces of evidence, whereby three key points emerged. DLBCL is a disease of malignant B cells spreading and accumulating both at nodal and at extranodal sites. In patients with both nodal and extranodal lesions, the subsequent induction of a cancer-friendly environment appears pivotal. The DLBCL cell interaction with mature stromal cells and vessels confers tumor protection and inhibition of immune response while delivering nutrients and oxygen supply. Single cells may also reside and survive in protected niches in the nodal and extranodal sites as a source for residual disease and relapse. This review aims to molecularly and functionally recapitulate the DLBCL–milieu crosstalk, to relate niche and pathological angiogenic constitution and interaction factors to DLBCL progression.

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“…In a meta-analysis of 8 studies conducted on 670 patients, positive VEGF expression in blood circulating lymphocytes and lymph nodes correlated with shorter survival in newly diagnosed DLBCL [102]. In another study performed on 149 newly diagnosed DLBCL, high serum VEGF level was associated with poorer prognosis [103].…”

Section: Increased Vascularization Vegf Expression and Mirnamentioning

confidence: 99%

New insights in Diffuse Large B Cell Lymphoma Pathobiology

Solimando¹,

Annese²,

Tamma³

et al. 2020

Preprint

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Diffuse large B cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL), accounting for about 40% of all cases NHL. Analysis of the tumour microenvironment is an important aspect of the assessment of the progression of DLBCL. In this review article, we have analyzed the role of different cellular components of the tumour microenvironment, including mast cells, macrophages, lymphocytes, in tumour progression of DLBCL. We examined several approaches to confront the available pieces of evidence; three key points emerged. DLBCL is a disease of malignant B-cells spreading and accumulating both at nodal and in extranodal sites. Both in patients with nodal and extranodal lesions, the subsequent induction of a cancer-friendly environment appears pivotal. DLBCL cell interaction with mature stromal cells and vessels confers tumour protection and inhibition of immune response while delivering nutrients and oxygen supply. Single cells may also reside and survive in protected niches in the nodal and extranodal sites as a source for residual disease and relapse. This review aims to molecularly and functionally recapitulate the DLBCL-milieu crosstalk, to relate niche and pathological angiogenic constitution and interaction factors to DLBCL progression.

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Abnormal vascular endothelial growth factor protein expression may be correlated with poor prognosis in diffuse large B-cell lymphoma: A meta-analysis

Abstract: The major findings of our meta-analysis reveal that the aberrant expression of VEGF may correspond to shorter overall survival of patients with DLBCL, revealing that VEGF expression could be an unbiased prognostic determinant in the management of DLBCL patients.

Cited by 8 publications

References 0 publications

VEGF121, is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers

VEGF121, is predictor for survival in activated B-cell-like diffuse large B-cell lymphoma and is related to an immune response gene signature conserved in cancers

New Insights into Diffuse Large B-Cell Lymphoma Pathobiology

New insights in Diffuse Large B Cell Lymphoma Pathobiology

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