Abstract:Objective: The classical osteoporotic signaling pathways include the four key factors (LRP5, Runx2, Osterix, and RANKL) influencing the regulation of osteogenesis and osteoclastogenesis. The purpose of this study is to investigate the variations of these four factors in bone specimens associated with fractures of osteoporotic rats. Methods: Osteoporotic rats as osteoporotic group were randomly divided into three groups: group A, group B and group C. Non-osteoporotic rats as control group were divided into thre… Show more
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