International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Case Report: A reproductive-aged woman presented abnormal uterine bleeding of unknown reason with a heavy bleeding intermenstrual period. By physical examination, laboratory and imaging tests, pregnancy, iatrogenic cause, systemic condition and genital tract pathology were excluded. After high doses of estrogen with oxytocin and intrauterine balloon pipe treatment, the bleeding gradually reduced and stopped. Conclusion: Abnormal uterine bleeding is one of the most common reasons that reproductiveaged women seek health care. In rare complicated cases, however, the causes are difficult to identify which will lead to a delay in treatment and significant loss of the blood.