Abnormal Uterine Bleeding

Khafaga, Ashraf; Goldstein, Steven R.

doi:10.1016/j.ogc.2019.07.001

Cited by 36 publications

(35 citation statements)

References 22 publications

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“…To develop effective treatments for treatment of endometrial adenocarcinoma, it is important to identify the factors underlying tumorigenesis, invasion and metastasis. One of the clinical features of endometrial adenocarcinoma is uterine bleeding (30,31). Normal endometrium exhibits proliferative, secretory and atrophic properties (32,33).…”

Section: Discussionmentioning

confidence: 99%

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor

Chen

Zhang³

et al. 2020

Oncol Rep

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Endometrial adenocarcinoma is one of the most common types of gynecological malignancies and its incidence and mortality rates are increasing. Due to tumor recurrence and metastasis, the overall five-year survival rate of patients with endometrial adenocarcinoma is shortened. The aim of the present was to investigate the role of the polycomb group protein B-lymphoma Mo-MLV insertion region 1 (BMI-1) in the invasion, metastasis and the epithelial-mesenchymal transition (EMT) of endometrial adenocarcinoma cells, as well its effects on the prognosis of patients with endometrial adenocarcinoma. Immunohistochemistry was used to examine the expression profile of BMI-1 in normal and endometrial adenocarcinoma tissues. Western blotting was used to examine the expression levels of BMI-1 and EMT markers. Kaplan-Meier plots and a Cox proportional hazards model were used to assess the overall survival. MTT cell viability assays were used to detect the proliferation of endometrial cancer cells. Transwell assays were used to examine cell migration and invasion. Small interfering RNA was used to downregulate BMI-1 expression levels, to study its effect on EMT. Immunohistochemical and clinicopathological analyses showed that BMI-1 expression was increased in endometrial adenocarcinoma tissue compared with the normal endometrial tissue (P<0.05). The increased expression levels of BMI-1 were closely associated with stage, myometrial invasion and lymph node metastasis (P<0.05). Kaplan-Meier plots and a Cox proportional hazards model showed that increased BMI-1 expression was associated with a less favorable prognosis [P=0.040, hazards ratio (HR)=1.596] and was associated with late-stage adenocarcinoma (P=0.006, HR=1.670). Myometrial invasion (P=0.006, HR=1.509) and lymph node metastasis (P=0.004, HR=1.703) were determined to predict a less favorable prognosis. Downregulation of BMI-1 reduced migration and invasion in endometrial cancer cells in vivo. It was also found that downregulation of BMI-1 increased the expression levels of the epithelial markers E-cadherin and keratin, and decreased the expression levels of the mesenchymal markers N-cadherin, vimentin and the downstream transcription factor, Slug. In conclusion, BMI-1 expression was correlated with tumor invasion and metastasis, contributing to deep myometrial invasion and lymph node metastasis, and was a poor prognostic factor for endometrial adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor

Chen

Zhang³

et al. 2020

Oncol Rep

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“…Risk of malignant ovarian tumors increases with age. A US population based survey of ages 18-50 reported an annual prevalence rate of AUB as 53 per 1000 women [27] .…”

Section: Prevalencementioning

confidence: 99%

Abnormal uterine bleeding and its homoeopathic approach

Devi¹

2021

Int. J. Homoeopathic Sci.

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Many women have variations in their menstrual cycles such as changes in frequency, duration, amount of flow or spotting between the periods. This Abnormal Uterine Bleeding is common debilitating condition in women. It can occur between Menarche to Menopause in Ovulatory or Anovulatory cycles. Many structural causes like polyps, fibroids; functional and coagulopathies can lead to abnormal uterine bleeding. Excessive Menstrual Bleeding has several adverse effects including Anaemia, Iron deficiency and reduced quality of life. It affects medical and social health of women. Medical management is the preferred initial approach for hemo-dynamically stable patients to avoid surgical risks and preserve fertility. Knowledge of nature of individual sickness is necessary to prescribe and this depends upon study of symptoms prior to the pathology. Hahnemannian Homeopathy supplied a law to knit together the two branches of medical knowledge and has thereby put the art of medicine on a scientific basis.

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“…Nenormalus kraujavimas iš gimdos yra dažnas ginekologinis skundas, kuris sudaro trečdalį ambulatorinių apsilankymų pas ginekologus ir daugiau nei 70 proc. visų ginekologų konsultacijų perimenopauzės ir pomenopauzės metais [3]. Pomenopauzinis kraujavimas (PK) -tai kraujavimas iš gimdos, atsirandantis praėjus mažiausiai vieneriems metams nuo menopauzės pradžios [4].…”

Section: įVadasunclassified

Pomenopauzinis Kraujavimas Iš Gimdos: Klasifikacija, Priežastys, Diagnostika, Gydymas

Skvarnavičiūtė¹

2021

Health Sciences

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Pomenopauzinis kraujavimas – tai kraujavimas iš gimdos, atsirandantis praėjus mažiausiai vieneriems metams nuo menopauzės pradžios. Tai dažna medicininė problema, tiesiogiai veikianti moterų gyvenimo kokybę, sveikatos priežiūros išteklių panaudojimą ir išlaidas. Kraujavimas po menopauzės yra viena iš dažniausių priežasčių, dėl kurių moterys kreipiasi į gydytojus akušerius ginekologus. Pomenopauzinio kraujavimo iš gimdos gydymas priklauso nuo diagnozuotos kraujavimo priežasties ir turėtų būti pritaikytas individualiai, atsižvelgiant į pacientės sveikatos būklę, tikslus. Pomenopauzinis kraujavimas gali būti pirmasis endometriumo vėžio požymis, todėl klinikinis kraujavimo po menopauzės tyrimas reikalingas greito ir efektyvaus įvertinimo, kad būtų diagnozuota ir gydoma endometriumo karcinoma ar endometriumo hiperplazija. Tyrimo tikslas – išsiaiškinti pomenopauzinio kraujavimo iš gimdos klasifikaciją, priežastis, diagnostiką ir gydymą. Metodika. Literatūra buvo rinkta naudojant Pubmed duomenų bazę. Išvados. Kraujavimas pomenopauziniu laikotarpiu yra dažna kreipimosi į gydytojus ginekologus priežastis. Kraujavimas iš gimdos turėtų būti įvertintas remiantis PALM – COEIN klasifikacija. Šiuo metu histeroskopija su atliekamomis biopsijomis yra auksinis standartas diagnozuoti endometriumo anomalijas. Gydymas priklauso nuo kraujavimo etiologijos, taikomas individualiai, atsižvelgiant į pacientės sveikatos būklę, tikslus.

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Abnormal Uterine Bleeding

Cited by 36 publications

References 22 publications

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor

BMI‑1 promotes invasion and metastasis in endometrial adenocarcinoma and is a poor prognostic factor

Abnormal uterine bleeding and its homoeopathic approach

Pomenopauzinis Kraujavimas Iš Gimdos: Klasifikacija, Priežastys, Diagnostika, Gydymas

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