Abnormal Urinary Coproporphyrin Levels in Patients Infected by Hepatitis C Virus With or Without Human Immunodeficiency Virus

Cribier, B.

doi:10.1001/archderm.1996.03890360034007

Cited by 37 publications

(15 citation statements)

References 7 publications

(7 reference statements)

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“…In a series of 56 HCV-infected patients, Cribier et al (26) found slightly elevated median urinary porphyrin excretion, however, data on the distribution of the respective values were not given; in addition, porphyrin concentrations of random urine samples were not corrected for urinary creatinine in this study, and coproporphyrin isomer distribution was not investigated. In another cohort of 34 HCV-infected patients, O'Reilly et al (27) were not able to demonstrate significant urinary porphyrin changes.…”

Section: Discussionmentioning

confidence: 71%

“…Only few systematic studies on urinary porphyrin excretion, with conflicting results, have been performed in well defined groups of patients with liver diseases (5,6,(25)(26)(27)(28)(29); therefore, links between abnormal porphyrin metabolism, disease progression to cirrhosis and hepatocarcinogenesis in heptatitis C are so far unclear. In order to obtain basic epidemiological data on urinary porphyrin excretion in liver diseases for further study on prognostic implications we studied urine porphyrin excretion patterns in patients with chronic HCV infection.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Porphyrin Excretion in Hepatitis C Infection

Vogeser¹,

Jacob²,

Zachoval³

1999

CCLM

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A high prevalence of hepatitis C virus infection in porphyria cutanea tarda in some populations suggests a close link between viral hepatitis and alteration of porphyrin metabolism. Moreover, there is evidence of a role of porphyrinopathies in hepatocarcinogenesis. The aim of our study was to obtain data on the prevalence and patterns of heme metabolism alterations in patients with chronic hepatitis C virus infection. Urinary porphyrin excretion was prospectively studied in 100 consecutive outpatients with chronic hepatitis C infection without signs of photosensitivity, using an ion-pair high-performance liquid chromatography method. Increased total porphyrin excretion was found in 41 patients, with predominant excretion of coproporphyrins (whole study group: mean 146 µg/g creatinine, interquartile range 76-186; normal < 150), in 10 patients excretion exceeded 300 µg/g creatinine. In the majority of all patients studied (75/100) an increased ratio of the relatively hydrophobic coproporphyrin isomer I to isomer III was found. In just one case, urinary porphyrin pattern characteristic for chronic hepatic porphyria was present (uroporphyrin > coproporphyrin, heptacarboxyporphyrin III increased) but the total porphyrin excretion was only slightly elevated in this case. In the whole group, total urinary porphyrin excretion correlated well with serum bilirubin and was inversely correlated with albumin and thrombin time. In conclusion, secondary coproporphyrinuria occurs frequently in heptatitis C infection, whereas in Germany, preclinical porphyria cutanea tarda seems to be rare in these patients.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Urinary Porphyrin Excretion in Hepatitis C Infection

Vogeser¹,

Jacob²,

Zachoval³

1999

CCLM

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“…67 There must be a predisposition for Urod deficiency, because most patients with hepatitis C do not develop PCT. 68 As PCT may be the first indication of an HCV infection, it is important to be searched in all patients. 69 The hypotheses explaining the role of HCV in PCT encompass: (1) lower Urod activity secondary to hepatocyte injury; 64,70 (2) changes in the cytochrome P450 oxidase-dependent system; 70 and (3) increased auto-immune response in the liver.31 Auto-antibodies would occur due to a mechanism of molecular mimicking 71 and they act as inhibitors of the Urod catalytic activity.…”

Section: Triggerrring Factorsmentioning

confidence: 99%

Porfiria cutânea tardia

Vieira

Martins

2006

An. Bras. Dermatol.

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“…HCV patients have an increase of urinary coproporphyrin excretion 39 related to hepatic changes of porphyrin metabolism. Our control group of nonporphyric HCV-infected patients showed a small increase of hepatic porphyrins with respect to normal controls.…”

Section: Discussionmentioning

confidence: 99%

Hepatic uroporphyrinogen decarboxylase activity in porphyria cutanea tarda patients: The influence of virus C infection

et al. 1998

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Porphyria cutanea tarda (PCT) is caused by a decreased activity of the hepatic enzyme uroporphyrinogen decarboxylase (URO-D). This deficiency causes overproduction, hepatic deposition, and increased excretion of uroporphyrin. Iron overload and hepatic viral infections are considered aggravating factors of the disease. Two forms of PCT have been described, as follows: a familial one with an inherited decrease of URO-D activity in all tissues and a sporadic one with a decreased activity of URO-D restricted to the liver. To assess whether the hepatic URO-D returns to normal during a remission of the disease, this activity was measured in liver biopsy samples in 24 sporadic PCT patients. The hepatic and urinary porphyrin concentrations were also measured. Viral status and histopathological findings were analyzed to assess their involvement in PCT. Six patients treated by phlebotomy to reduce hepatic iron and who were considered to be in clinical remission, characterized by a disappearance of cutaneous lesions, showed higher hepatic URO-D activities and lower hepatic porphyrin concentrations than did patients with overt PCT. The medians of these variables, however, did not achieve normal values. The hepatic URO-D activity showed a significant inverse relationship with both hepatic porphyrins and urinary uroporphyrin excretion. Hepatic URO-D activity was not reduced by hepatitis C virus (HCV) infection and liver damage. We conclude that the achievement of remission in PCT largely depends on the transient normalization of hepatic URO-D activity. A small increase in hepatic coproporphyrin in nonporphyric patients could reflect hepatic injury/iron/alcohol-induced oxidative stress oxidizing the accumulated heme precursors rather than a direct effect on hepatic URO-D enzyme. (HEPATOLOGY 1998; 27:584-589.)

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Abnormal Urinary Coproporphyrin Levels in Patients Infected by Hepatitis C Virus With or Without Human Immunodeficiency Virus

Cited by 37 publications

References 7 publications

Urinary Porphyrin Excretion in Hepatitis C Infection

Urinary Porphyrin Excretion in Hepatitis C Infection

Porfiria cutânea tardia

Hepatic uroporphyrinogen decarboxylase activity in porphyria cutanea tarda patients: The influence of virus C infection

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