Abnormal troponin level as short-term predictor of poor outcome in acute atrial fibrillation

Conti, Alberto; Mariannini, Yuri; Viviani, Gabriele; Poggioni, Claudio; Cerini, Gabriele; Luzzi, Margherita; Zanobetti, Maurizio; Innocenti, Francesca; Padeletti, Luigi; Gensini, Gian Franco

doi:10.1016/j.ajem.2012.12.031

Cited by 23 publications

(12 citation statements)

References 33 publications

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“…During the one year of follow-up, the troponin tested group with a mean 0.56 ng/ml (range of 0.05–4.17ng/ml)] had higher rates of MI (7%) compared to those who had a negative troponin (1%). In addition to this, two other single site studies found similar results to Gupta et al and are listed in Table 2 [34, 35]. …”

Section: Atrial Fibrillation As a Risk Factor For Acute Coronary Syndsupporting

confidence: 84%

A Review of the Relationship of Atrial Fibrillation and Acute Coronary Syndrome

Kea

Alligood

Manning

et al. 2016

Curr Emerg Hosp Med Rep

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Atrial fibrillation (AF) is the most common arrhythmia encountered by clinicians. Clinical decision-making focuses on reducing ischemic stroke risk in AF patients; however, AF is also associated with an increased risk of acute coronary syndromes (ACS). Patients with ACS and concurrent AF are less likely to receive appropriate therapies and more likely to experience adverse outcomes than ACS patients in sinus rhythm (SR). Clinicians may be able to stratify ACS patients at increased risk of AF development based on clinical characteristics. Evidence supporting specific therapeutic options for prevention of ACS in AF patients or for prevention of AF in ACS patients is limited, however there is some evidence of differing effects among oral anticoagulant regimens in these populations. Investigations of the relationship of AF with the full spectrum of ACS are not well described and should be the focus of future research.

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Section: Atrial Fibrillation As a Risk Factor For Acute Coronary Syndsupporting

confidence: 84%

A Review of the Relationship of Atrial Fibrillation and Acute Coronary Syndrome

Kea

Alligood

Manning

et al. 2016

Curr Emerg Hosp Med Rep

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“…However, troponin elevation in these settings translates into poorer prognosis and increased mortality [16][17][18][19].…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure

Alghamry

Hanna

Pelecanos

et al. 2016

International Journal of Cardiology

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“…The results demonstrated that there was additional prognostic value of MMP-2 and MMP-9 gene polymorphisms on the Cox model. C-statistic is often used to demonstrate the prognostic value of certain indexes in a model [43, 44]. By implementing several biomarkers to existing risk prediction models, the net reclassification index (NRI) draws conclusions about improvements in prediction model performance [45].…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between MMP-2 -1306C>T and MMP-9 -1562C>T Polymorphisms and the Risk and Prognosis of T-Cell Acute Lymphoblastic Leukemia in a Chinese Population: A Case-Control Study

Lin

Zeng

Xiao

et al. 2017

Cell Physiol Biochem

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Background: T-cell acute lymphoblastic leukemia (T-ALL) is a malignant hematological disease and is often accompanied by a variety of genetic abnormalities. Hence, our study aims to investigate the relationship between MMP-2 -1306C>T and MMP-9 -1562C>T polymorphisms and the risk and prognosis of T-ALL. Methods: From April 2009 to February 2011, a total of 376 T-ALL patients were chosen as the case group. Meanwhile, 352 healthy people who passed routine health examinations were selected as the control group. A polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was used to detect the frequency of MMP-2 -1306C>T (rs243865) and MMP-9 -1562C>T (rs3918242) polymorphisms in the study subjects. The serum levels of MMP-2 and MMP-9 were detected using enzyme-linked immunosorbent assay (ELISA). A Kaplan-Meier analysis was employed to analyze the event-free survival (EFS) rates of the T-All patients with different MMP-2 and MMP-9 genotypes. A multivariate COX model was applied to analyze the relationship between MMP-2 and MMP-9 polymorphisms and the prognosis of T-ALL patients. A C-statistic and net reclassification index (NRI) was carried out to evaluate the predictive value of MMP-2 and MMP-9 gene polymorphisms using the Cox model. Results: Compared to the control group, the genotypic frequency of MMP-2 -1306C>T (CT + TT) and MMP-9 -1562C>T (CT + TT) in the case group was significantly higher. The serum level of MMP-9 was markedly elevated in T-ALL patients with the CT + TT genotype compared to patients with the CC genotype. The results of the Kaplan-Meier analysis showed that the median EFS was lower in T-ALL patients with the CT + TT genotype of MMP-9 -1562C>T compared to patients with the CC genotype. The results of a multivariate analysis using the Cox proportional hazard model indicated that the MMP-9 -1562C>T polymorphism was associated with the prognosis of T-ALL patients. Conclusion: These results indicated that MMP-2 -1306C/T and MMP-9 -1562C/T polymorphisms might be associated with an increased risk of T-ALL. The MMP-9 -1562C>T polymorphism may also be related to the prognosis of T-ALL patients.

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Abnormal troponin level as short-term predictor of poor outcome in acute atrial fibrillation

Cited by 23 publications

References 33 publications

A Review of the Relationship of Atrial Fibrillation and Acute Coronary Syndrome

A Review of the Relationship of Atrial Fibrillation and Acute Coronary Syndrome

Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure

The Relationship Between MMP-2 -1306C>T and MMP-9 -1562C>T Polymorphisms and the Risk and Prognosis of T-Cell Acute Lymphoblastic Leukemia in a Chinese Population: A Case-Control Study

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