Abnormal theta oscillation aggravated by chronic stress in the CA1 may mediate the deterioration of fear memory impairment induced by lipopolysaccharide

Mao, Min; Gao, Yu-Zhu; Yang, Jianjun; Zhou, Zhengdong; Ji, Mu‐Huo

doi:10.1016/j.brainresbull.2021.03.012

Cited by 5 publications

(1 citation statement)

References 27 publications

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“…Subsequent studies used the social recognition paradigm [ 68 , 155 ], and we confirmed social memory impairment in our local colony as well [ 14 , 15 , 16 ]. However, AVP has a substantial effect on social behavior independently of memory formation [ 156 , 157 ]; therefore, to study memory formation, the novel object recognition (NOR) test seems to be a better choice. Previously we described NOR disturbance in our di/di animals [ 15 , 16 ].…”

Section: Memory Disturbances Associated With Improper Sleepmentioning

confidence: 99%

Vasopressin as a Possible Link between Sleep-Disturbances and Memory Problems

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Várga

Zelena

2022

IJMS

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Normal biological rhythms, including sleep, are very important for a healthy life and their disturbance may induce—among other issues—memory impairment, which is a key problem of many psychiatric pathologies. The major brain center of circadian regulation is the suprachiasmatic nucleus, and vasopressin (AVP), which is one of its main neurotransmitters, also plays a key role in memory formation. In this review paper, we aimed to summarize our knowledge on the vasopressinergic connection between sleep and memory with the help of the AVP-deficient Brattleboro rat strain. These animals have EEG disturbances with reduced sleep and impaired memory-boosting theta oscillation and show memory impairment in parallel. Based upon human and animal data measuring AVP levels, haplotypes, and the administration of AVP or its agonist or antagonist via different routes (subcutaneous, intraperitoneal, intracerebroventricular, or intranasal), V1a receptors (especially of hippocampal origin) were implicated in the sleep-memory interaction. All in all, the presented data confirm the possible connective role of AVP between biological rhythms and memory formation, thus, supporting the importance of AVP in several psychopathological conditions.

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