Abnormal thermography in Parkinson's disease

Antonio-Rubio, I.; Madrid-Navarro, Carlos Javier; Salazar-López, E.; Pérez-Navarro, M.J.; Sáez-Zea, Carmen; Gómez-Milán, E.; Mínguez-Castellanos, Adolfo; Escamilla-Sevilla, Francisco

doi:10.1016/j.parkreldis.2015.05.006

Cited by 25 publications

(37 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, rats exposed to heat stress (ambient temperature = 45 ± 0.5°C) demonstrate a significant increase of dopamine and glutamate in the systemic circulation and hypothalamus, along with signs of hypothalamic inflammation . Moreover, abnormal thermoregulation, which is part of the spectrum of dysautonomia in PD, might trigger DHS, further enhancing the effect of high ambient temperature on dopaminergic receptors. This hypothesis is further supported by the presence of autonomic impairment in our cohort of PD patients with DHS.…”

Section: Discussionmentioning

confidence: 99%

Dyskinesia‐Hyperpyrexia Syndrome in Parkinson's Disease: A Heat Shock–Related Emergency?

Sarchioto

Ricchi

Melis

et al. 2018

Movement Disord Clin Pract

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Dyskinesia‐Hyperpyrexia Syndrome in Parkinson's Disease: A Heat Shock–Related Emergency?

Sarchioto

Ricchi

Melis

et al. 2018

Movement Disord Clin Pract

View full text Add to dashboard Cite

“…The CST consisted of immersing the naked dominant hand (without wearing gloves) in a bucket of cold water (3 6 1 8C) for 2 min. Subsequently, we recorded the thermal recovery of the hand during 6 min, exactly as has been done in previous research (Antonio-Rubio et al, 2015;Bharara, Viswanathan, & Cobb, 2008;Chlebicka, Matusiak, Baran, & Szepietowski, 2012;Lovallo, 1975;Pauling, Flower, Shipley, Harris, & McHugh, 2011;Stefa nczyk, Wo zniakowski, Pietrzak, Majos, & Grzelak, 2007). See Figure 1.…”

Section: Procedures and Settingsmentioning

confidence: 99%

The Pinocchio effect and the Cold Stress Test: Lies and thermography

et al. 2017

View full text Add to dashboard Cite

We applied the use of thermography to cognitive neuropsychology, particularly as an objective marker of subjective experiences, in the context of lying. We conducted three experiments: (a) An important lie was invented by the participants in 3 min, and it was recounted by phone to a significant person while they were recorded by the thermographic camera, obtaining a face and hands map of the lie. (b) A similar methodology was carried out, but adding the Cold Stress Test (CST) of the dominant hand during the phone call, obtaining a second physiologic marker (the percentage of thermal recovery) to detect the lie. Further, it established a control condition where it generated anxiety in the participants using IAPS images with negative valence and high arousal, which were described by phone to a loved one. We obtained results that showed significant correlations between changes in body temperature and mental set. Of particular interest was the temperature of the nose and hand, which tended to decrease during lying (Experiment 1). The participants also showed a lower recovery of the temperature after the CST when they were lying (Experiment 2). (c) Experiment 3 is a replication of Experiment 2 but with a different type of lie (a more ecological task) in a different scenario (following the ACID interview, with the use of the phone eliminated and participants motivated to lie well). The main pattern of results was replicated. We obtained an accuracy of 85% in detection of deception with 25% of false alarms.

show abstract

“…Ambulatory circadian monitoring (ACM), a procedure proposed by Ortiz-Tudela et al ( 3 ), is supported by wearable technology which combines four categories of variables useful for tracking complex neurological pathologies such as PD, since: wrist temperature rhythm is expected to be impaired in PD, as there is an abnormal thermoregulation in the distal skin, with an impaired vasoconstriction response to adrenergic stimulus ( 19 , 20 ), as well as alterations in normal blood pressure pattern dipping ( 11 ). motor-related variables (integrated acceleration, time in movement and static hand position), indicate both wake states and cardinal motor symptoms of PD disease, and are more dependent on the subject’s habits than they are on the circadian clock.…”

Section: Introductionmentioning

confidence: 99%

Multidimensional Circadian Monitoring by Wearable Biosensors in Parkinson’s Disease

et al. 2018

View full text Add to dashboard Cite

Parkinson’s disease (PD) is associated with several non-motor symptoms that may precede the diagnosis and constitute a major source of frailty in this population. The digital era in health care has open up new prospects to move forward from the qualitative and subjective scoring for PD with the use of new wearable biosensors that enable frequent quantitative, reliable, repeatable, and multidimensional measurements to be made with minimal discomfort and inconvenience for patients. A cross-sectional study was conducted to test a wrist-worn device combined with machine-learning processing to detect circadian rhythms of sleep, motor, and autonomic disruption, which can be suitable for the objective and non-invasive evaluation of PD patients. Wrist skin temperature, motor acceleration, time in movement, hand position, light exposure, and sleep rhythms were continuously measured in 12 PD patients and 12 age-matched healthy controls for seven consecutive days using an ambulatory circadian monitoring device (ACM). Our study demonstrates that a multichannel ACM device collects reliable and complementary information from motor (acceleration and time in movement) and common non-motor (sleep and skin temperature rhythms) features frequently disrupted in PD. Acceleration during the daytime (as indicative of motor impairment), time in movement during sleep (representative of fragmented sleep) and their ratio (A/T) are the best indexes to objectively characterize the most common symptoms of PD, allowing for a reliable and easy scoring method to evaluate patients. Chronodisruption score, measured by the integrative algorithm known as the circadian function index is directly linked to a low A/T score. Our work attempts to implement innovative technologies based on wearable, multisensor, objective, and easy-to-use devices, to quantify PD circadian rhythms in huge populations over extended periods of time, while controlling at the same time exposure to exogenous circadian synchronizers.

show abstract

Abnormal thermography in Parkinson's disease

Cited by 25 publications

References 27 publications

Dyskinesia‐Hyperpyrexia Syndrome in Parkinson's Disease: A Heat Shock–Related Emergency?

Dyskinesia‐Hyperpyrexia Syndrome in Parkinson's Disease: A Heat Shock–Related Emergency?

The Pinocchio effect and the Cold Stress Test: Lies and thermography

Multidimensional Circadian Monitoring by Wearable Biosensors in Parkinson’s Disease

Contact Info

Product

Resources

About