Abnormal temporal dynamics of visual attention in Alzheimer's disease and in dementia with Lewy bodies

Peters, Frédéric; Ergis, Anne-Marie; Gauthier, Serge; Dieudonné, Bénédicte; Verny, Marc; Jolicœur, Pierre; Belleville, Sylvie

doi:10.1016/j.neurobiolaging.2011.10.019

Cited by 8 publications

(26 citation statements)

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“…The pulvinar exerts a powerful influence on cortical activity based on attentional demands, 47 meaning its dysfunction likely impacts attention-mediated cortical functions. Attention is deficient in DLB 48,49 and has been implicated in visual hallucinations and fluctuating cognition. 11,48 The search for the neuropathological substrates of symptoms such as visual hallucinations and cognitive fluctuations is impeded by the inherent difficulty in attributing a transient feature to a permanent neuropathological change.…”

Section: Discussionmentioning

confidence: 99%

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

et al. 2018

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These results indicate that the pulvinar, a region with relatively low Lewy body pathological burden, manifests changes at the molecular level that differ from previous reports in a more severely affected region. We speculate that these alterations result from neurodegenerative changes in regions connected to the pulvinar and likely contribute to a variety of cognitive changes resulting from decreased cortical synchrony in dementia with Lewy bodies. © 2018 International Parkinson and Movement Disorder Society.

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Section: Discussionmentioning

confidence: 99%

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

et al. 2018

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“…However, aging does appear to significantly impact myelinated nerve fibers as well as some microstructural changes in neocortical anatomy. Specifically, Peters and colleagues have published several reports on structural changes, such as increased lipofuscin within cells and loss of dendritic spines in the cerebral cortex of rhesus macaque monkeys (Peters et al, 1998; Page et al, 2002; Peters and Rosene, 2003; Peters, 2007, 2009; Peters and Kemper, 2012). The cell type within neocortex that seems to demonstrate the greatest age-related alteration is neuroglia (Peters, 2007).…”

Section: Aging and Cortical Neuron Morphology And Wiringmentioning

confidence: 99%

“…The cell type within neocortex that seems to demonstrate the greatest age-related alteration is neuroglia (Peters, 2007). Although some structures such as the anterior commissure (Sandell and Peters, 2003), and layer 1 in cortical areas 17 and 46 (Peters and Sethares, 2002) do not show a significant change in neuroglial numbers with age; there is a 45% age-related increase in the number of oligodendrocytes in area 46 (Peters and Kemper, 2012), a 20% increase in fornix (Sandell and Peters, 2002), and a 50% increase in area 17 (Peters and Kemper, 2012). These age-related changes in glia appear to be area-specific, could be generated from an integration of genetic and epigenetic processes and may be relate to functional changes in neocortex that lead to cognitive decline in aging.…”

Section: Aging and Cortical Neuron Morphology And Wiringmentioning

confidence: 99%

“…Natural age-related demyelination is observed in the primate model and may represent damage to the intra-neocortical circuitry, which, in turn, could lead to cognitive decline (Peters, 2009). Peters and Kemper (2012) posit that age-related cognitive decline correlates with and possibly results from problems with myelination, altered intra-neocortical connectivity, and abnormal synaptic and dendritic function.…”

Section: Aging and Cortical Neuron Morphology And Wiringmentioning

confidence: 99%

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The Developing, Aging Neocortex: How Genetics and Epigenetics Influence Early Developmental Patterning and Age-Related Change

Huffman¹

2012

Front. Gene.

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A hallmark of mammalian development is the generation of functional subdivisions within the nervous system. In humans, this regionalization creates a complex system that regulates behavior, cognition, memory, and emotion. During development, specification of neocortical tissue that leads to functional sensory and motor regions results from an interplay between cortically intrinsic, molecular processes, such as gene expression, and extrinsic processes regulated by sensory input. Cortical specification in mice occurs pre- and perinatally, when gene expression is robust and various anatomical distinctions are observed alongside an emergence of physiological function. After patterning, gene expression continues to shift and axonal connections mature into an adult form. The function of adult cortical gene expression may be to maintain neocortical subdivisions that were established during early patterning. As some changes in neocortical gene expression have been observed past early development into late adulthood, gene expression may also play a role in the altered neocortical function observed in age-related cognitive decline and brain dysfunction. This review provides a discussion of how neocortical gene expression and specific patterns of neocortical sensori-motor axonal connections develop and change throughout the lifespan of the animal. We posit that a role of neocortical gene expression in neocortex is to regulate plasticity mechanisms that impact critical periods for sensory and motor plasticity in aging. We describe results from several studies in aging brain that detail changes in gene expression that may relate to microstructural changes observed in brain anatomy. We discuss the role of altered glucocorticoid signaling in age-related cognitive and functional decline, as well as how aging in the brain may result from immune system activation. We describe how caloric restriction or reduction of oxidative stress may ameliorate effects of aging on the brain.

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“…This finding is independent of the age-appropriate visual acuity. Peters et al (2012) investigated the magnitude of the AB during performance of a RSVP task in AD patients. Two different task versions were presented to the participants: a single target condition and a dual target condition with one respectively two targets embedded into a sequence of digit distractors.…”

Section: The Locus Coeruleus-norepinephrine System Mediating the Attementioning

confidence: 99%

P1‐223: Functional Markers for Cerebral Norepinephrine Deficiency in Alzheimer’s Disease

Kiven

Loetgering

Kleineidam

et al. 2016

Alzheimer's & Dementia

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Background: In primary care units Frailty Ambulatory is dedicated to elderly people and is an example of health innovation. In the light of a complex rethinking of primary care, it is aimed to promote initiative medicine in the field of degenerative and chronic diseases. In short, Frailty Ambulatories have to make easier the "art" of caring elderly patients' complex needs through geriatricians and outof-hospital network services. The aim of the present study was to analyze data from 300 consecutive patients sent to our ambulatories. Methods:The starting point is caring patients and their needs. The first step is represented by over-65 year-old patients' selection according to the criteria of prefrailty and frailty (at least one Fried's criterion and the patient sent to geriatrician by general practitioner). Results:Of 300 patients, 118 (39,3%) were men, mean age 82,79 6 6,65 years old, BMI 22,176 2,15 kg/m 2 . After performing multidimensional assessment we found the following scores: MMSE 11,0562,44; ADL 0,9562,06; IADL 0,0460,188; CIRS 4,9561,72. The number of drugs used was 6,16 6 2,20. The most frequent Fried's criterion found was fatigue (97,3%, Table 1); criteria's mean/patient was 4,74 6 0,56. In 80,3% out of the patients all the five criteria were found, in 13.3% four criteria, in 6,4% three criteria (Figure 1). After bivariate relationship Fried's criteria were found to be significantly correlated to MMSE and heart failure. After multivariate analysis the relationship was kept with MMSE (beta -0,209; p¼0,0001). Conclusions: Experimental activity in Frailty Ambulatories could offer a tool able to recognize conditions of prefrailty/frailty. This can lead to a consistent and complete care response, preventing/decreasing disability conditions. Data analyses timely carried on by provincial health authority let plan the possible continuation of experimentation.Background:The locus coeruleus (LC) as the only source for norepinephrine (NE) in the human brain shows early degeneration in Alzheimer's disease (AD). The LC-NE system is involved in attentional processes and different behavioral and functional markers (e.g. evoked EEG potentials, BOLD responses, pupillary dilatation) have been identified as potential markers for LC-NEfunctionality. Here, we assessed whether these markers are characteristically altered in AD, thus providing potential surrogate markers for interventional trials targeting the LC-NE-system. Methods: We aim at including patients (planned: n¼30) with cerebrospinal fluid-biomarker evidence for AD and age-matched healthy controls (planned: n¼30). We obtain reaction times and accuracy, event-related electroencephalography (EEG) potentials (P300b), task-related pupil dilation and event-related blood oxygen level dependent (BOLD) responses in a stimulus detection task (Oddball-paradigm). Additionally, structural magnetic resonance imaging (MRI) with neuromelanine-sensitive sequences is applied to determine a volumetric measure for the LC. Here, we present preliminary results for 15 subjects with ...

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Abnormal temporal dynamics of visual attention in Alzheimer's disease and in dementia with Lewy bodies

Cited by 8 publications

References 47 publications

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

Molecular changes in the absence of severe pathology in the pulvinar in dementia with Lewy bodies

The Developing, Aging Neocortex: How Genetics and Epigenetics Influence Early Developmental Patterning and Age-Related Change

P1‐223: Functional Markers for Cerebral Norepinephrine Deficiency in Alzheimer’s Disease

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