Abnormal Temporal Coupling of Tactile Perception and Motor Action in Parkinson’s Disease

Conte, Antonella; Belvisi, Daniele; Tartaglia, Matteo; Cortese, Francesca; Baione, Viola; Battista, Emanuele; Zhu, Xiaoying; Fabbrini, Giovanni; Berardelli, Alfredo

doi:10.3389/fneur.2017.00249

Cited by 23 publications

(21 citation statements)

References 44 publications

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“…However, the direction of the changes in PD is opposite to the direction we observed in dystonia. In PD there is reduced modulation of STDT associated with slowing of movement execution during sensorimotor integration, whereas in our study we observed that movement velocity in patients with CD and FHD did not vary during the sensorimotor integration task.…”

Section: Discussioncontrasting

confidence: 90%

“…Abnormal modulation of the STDT during voluntary movement is also present in patients with Parkinson's disease (PD) . However, the direction of the changes in PD is opposite to the direction we observed in dystonia.…”

Section: Discussionmentioning

confidence: 75%

“…After a verbal "go" signal given by the examiner, the participants abducted the index finger. 7,[27][28][29] Marker displacement was reconstructed via dedicated software running the automatic algorithm to compute range of motion (ROM), which represents the displacement of the index finger around its metacarpophalangeal joint expressed as a degree of the angle and mean velocity (degree/sec; BTS Engineering).…”

Section: Kinematic Recordingsmentioning

confidence: 99%

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Abnormal sensory gating in patients with different types of focal dystonias

et al. 2018

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Background Movement execution in healthy individuals increases the somatosensory temporal discrimination threshold. These changes are a result of mechanisms of sensory gating at the subcortical level. Although the somatosensory temporal discrimination threshold is abnormally increased in patients with focal dystonias, the effect of movement execution on somatosensory temporal discrimination in dystonic patients is unknown. Objectives The objective of this study was to determine whether somatosensory temporal discrimination threshold modulation induced by voluntary movement is normal in different forms of focal dystonia. Methods We enrolled 71 dystonic patients (24 with blepharospasm, 31 with cervical dystonia, and 16 with focal hand dystonia) and 39 age‐matched healthy participants. Paired stimuli for the somatosensory temporal discrimination threshold were triggered by movement execution at movement onset and at various time intervals thereafter. We analyzed the kinematic features of the motor task to ascertain whether tactile input induces changes in movement parameters. Results Movement execution led to greater and longer lasting increases in somatosensory temporal discrimination threshold values, both upon movement onset and at various time intervals thereafter, in patients with cervical dystonia and focal hand dystonia than in those with blepharospasm or the healthy participants. Somatosensory temporal discrimination testing did not induce any changes in the mean velocity of index finger movements in either patients or healthy participants. Conclusions Somatosensory temporal discrimination threshold changes induced by movement execution are abnormal in focal dystonias. This abnormality is related to the type of dystonia. Abnormal gating of sensory information is likely involved in movement‐induced triggering or worsening of different forms focal dystonia. © 2018 International Parkinson and Movement Disorder Society

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionmentioning

confidence: 75%

Section: Kinematic Recordingsmentioning

confidence: 99%

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Abnormal sensory gating in patients with different types of focal dystonias

et al. 2018

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“…For this reason, it is considered that an abnormal TDT is a marker of defective inhibition within the superior colliculus or arising from substantia nigra pars compacta ( 34 ). Further strengthening the idea that these subcortical structures integrate temporal information comes from the altered TDT values reported in patients with various basal ganglia disorders ( 1 , 35 – 39 ).…”

Section: The Neuroanatomy Of Temporal Discriminationmentioning

confidence: 59%

Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia

et al. 2017

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Temporal discrimination is the ability to determine that two sequential sensory stimuli are separated in time. For any individual, the temporal discrimination threshold (TDT) is the minimum interval at which paired sequential stimuli are perceived as being asynchronous; this can be assessed, with high test–retest and inter-rater reliability, using a simple psychophysical test. Temporal discrimination is disordered in a number of basal ganglia diseases including adult-onset dystonia, of which the two most common phenotypes are cervical dystonia and blepharospasm. The causes of adult-onset focal dystonia are unknown; genetic, epigenetic, and environmental factors are relevant. Abnormal TDTs in adult-onset dystonia are associated with structural and neurophysiological changes considered to reflect defective inhibitory interneuronal processing within a network which includes the superior colliculus, basal ganglia, and primary somatosensory cortex. It is hypothesized that abnormal temporal discrimination is a mediational endophenotype and, when present in unaffected relatives of patients with adult-onset dystonia, indicates non-manifesting gene carriage. Using the mediational endophenotype concept, etiological factors in adult-onset dystonia may be examined including (i) the role of environmental exposures in disease penetrance and expression; (ii) sexual dimorphism in sex ratios at age of onset; (iii) the pathogenesis of non-motor symptoms of adult-onset dystonia; and (iv) subcortical mechanisms in disease pathogenesis.

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“…The STDT was investigated according to the experimental procedures used in previous studies [15,[37][38][39][40][41]. Paired tactile stimuli for STDT testing consisted of square-wave electrical pulses delivered by means of a constant current stimulator (Digitimer DS7AH) through surface electrodes over the distal phalanx of the right index finger.…”

Section: Stdt Testingmentioning

confidence: 99%

Somatosensory Temporal Discrimination Threshold in Patients with Cognitive Disorders

D'Antonio

Bartolo

Ferrazzano

et al. 2019

JAD

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Background:The temporal processing of sensory information can be evaluated by testing the somatosensory temporal discrimination threshold (STDT), which is defined as the shortest interstimulus interval needed to recognize two sequential sensory stimuli as separate in time. The STDT requires the functional integrity of the basal ganglia and of the somatosensory cortex (S1). Although there is evidence that time processing is impaired in patients with Alzheimer's disease (AD), no study has yet investigated STDT in patients with various degree of cognitive impairment. Objective: The aim of our study was to understand how cognition and attention deficits affect STDT values in patients with cognitive abnormalities. Methods: We enrolled 63 patients: 28 had mild-moderate AD, 16 had mild cognitive impairment (MCI), and the remaining 19 had subjective cognitive deficit (SCD). A group of 45 age-matched healthy subjects acted as controls. Paired tactile stimuli for STDT testing consisted of square-wave electrical pulses delivered with a constant current stimulator through surface electrodes over the distal phalanx of the index finger. Results: STDT values were higher in AD and MCI patients than in SCD subjects or healthy controls. Changes in the STDT in AD and MCI were similar in both conditions and did not correlate with disease severity. Conclusions: STDT alterations in AD and MCI may reflect a dysfunction of the dopaminergic system, which signals salient events and includes the striatum and the mesocortical and mesolimbic circuits.

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Abnormal Temporal Coupling of Tactile Perception and Motor Action in Parkinson’s Disease

Cited by 23 publications

References 44 publications

Abnormal sensory gating in patients with different types of focal dystonias

Abnormal sensory gating in patients with different types of focal dystonias

Temporal Discrimination: Mechanisms and Relevance to Adult-Onset Dystonia

Somatosensory Temporal Discrimination Threshold in Patients with Cognitive Disorders

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