Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis

Evolution of Cortical and Thalamus Atrophy and Disability Progression in Early Relapsing-Remitting MS during 5 Years

“…Normalized whole-brain, normalized GM, normalized WM volume, normalized cortical, and normalized lesion volume were measured as previously described. 30 For longitudinal changes of the whole-brain volume, we applied the SIENA method 31 to calculate the percentage brain volume change. To quantify longitudinal GM, WM, and cortical and lateral ventricle percentage volume changes, we used a modified hybrid of SIENA and SIENAX in FMRIB.…”

“…33 Normalized SDGM volumes were obtained by multiplying the estimated volumes from this tool by the volumetric scaling factor from SIENAX. 30 Statistical Analyses. The 5-year evaluation of the associations between SDGM, cortical atrophy measures, and disability progression was preplanned.…”

Cognitive and White Matter Tract Differences in MS and Diffuse Neuropsychiatric Systemic Lupus Erythematosus

“…22,23 Lesions were evaluated on FLAIR images with reference to T2/proton-attenuation images. A semiautomated edge-detection contouring-thresholding technique was used to create subjectspecific binary lesion masks, also used in Zivadinov et al 24 The DTI was corrected for motion and eddy current distortion by using the FMRIB Diffusion Toolbox (http://www.fmrib.ox. ac.uk/fsl/fdt/index.html).…”

Subcortical Atrophy Is Associated with Cognitive Impairment in Mild Parkinson Disease: A Combined Investigation of Volumetric Changes, Cortical Thickness, and Vertex-Based Shape Analysis

“…All WM hyperintensity masks were created by a single rater (E.M.), blinded to clinical characteristics and tests results, with similar reproducibility as previously reported. 36 Subsequently, FIRST was used to segment the amygdala, hippocampus, nucleus accumbens, pallidum, caudate nucleus, putamen, and thalamus from the in-painted T1. 23 The reproducibility of FIRST has been previously reported.…”