Abnormal shape of the cavum septi pellucidi: an indirect sign of partial agenesis of the corpus callosum

Shen, O.; Gelot, Antoinette; Moutard, Marie‐Laure; Jouannic, Jean‐Marie; Sela, Hen Y.; Garel, Catherine

doi:10.1002/uog.14776

Cited by 40 publications

(42 citation statements)

References 16 publications

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“…Diagnosing SCC is challenging. Many previous studies suggested various diagnostic tools in an attempt to confront this problem . There are several reference charts for assessing CC biometrics according to gestational age .…”

Section: Discussionmentioning

confidence: 99%

A new method for evaluating short fetal corpus callosum

et al. 2019

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Objective Sonographic diagnosis of short corpus callosum (SCC) is based on measurement of a short for gestational age antero‐posterior length of the corpus callosum (CC) in the midsagittal plane. We suggest a new method for evaluating SCC without referring to biometry tables. Methods We measured the ratio between the CC length and the internal cranial occipitofrontal dimension (ICOFD) in the midsagittal plane in 399 normal fetuses at 20 + 6 to 35 + 3 weeks of gestation and in 31 fetuses with a diagnosis of a SCC and compared the mean ratio between two groups. The impact of cephalic biometric parameters, fetal presentation, and gender was assessed. Results The ICOFD/CC length for normal pregnancies was constant throughout the pregnancy (2.35 ± 0.11). There was no correlation between the ICOFD/CC length and cephalic index, Biparietal Diameter (BPD), head circumference, fetal sex, or fetal presentation. The ratio of pregnancies with SCC was significantly higher: 3.20 ± 0.84 (P < .0001). Conclusion The ICOFD/CC length practically does not change throughout a normal pregnancy. The ratio was significantly higher in pregnancies with SCC. Measuring this ratio during fetal anatomical scan may enable rapid evaluation of the CC without the need to refer to biometry tables.

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Section: Discussionmentioning

confidence: 99%

A new method for evaluating short fetal corpus callosum

et al. 2019

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“…In recent years, some authors have suggested that an abnormally shaped CSP may be a valid indirect sign of pACC . Shen has proposed that CSP shape be included as a new indirect sign, having found an abnormally shaped CSP in 52% of isolated pACC occurrences with no customary indirect signs.…”

Section: Discussionmentioning

confidence: 99%

“…As reported, approximately one‐third of isolated pACC defects carry the potential for some degree of neurologic morbidity, thus highlighting the need to identify this anomaly. In recent years, some authors have suggested that an abnormally shaped CSP may be a valid indirect sign of pACC . The aim of this study was to evaluate the performance of indirect sonographic signs in detecting pACC at midgestation, using the CSP ratio as a new indirect finding.…”

Section: Introductionmentioning

confidence: 99%

Utility of indirect sonographic signs (including cavum septum pellucidum ratio) in midgestational screening for partial agenesis of corpus callosum

Zhao

Wang

Cai

2019

J of Clinical Ultrasound

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Purpose This study was undertaken to evaluate the performance of indirect sonographic signs in detecting partial agenesis of the corpus callosum (pACC) at midgestation, focusing on the cavum septum pellucidum (CSP) ratio. Methods A retrospective case‐controlled study of singleton pregnancies was conducted, examining fetuses diagnosed with isolated pACC and normal controls. At midgestational age, fetal head volumes were imaged with 3D US and stored for the evaluation of indirect sonographic findings in axial planes. Results Fifteen normal and 15 abnormal fetuses (with pACC) were analyzed. Based on a CSP ratio < 1.5, detection of pACC increased from 66.7% (10/15) to 80% (12/15). All indirect signs proved highly suspicious for pACC (risk ratios > 1). Conclusion Use of indirect sonographic signs to screen for pACC at midgestation is challenging. However, a low CSP ratio may improve the detection rate, serving as a new indirect sign.

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“…A CSP with a large width may indicate an increased risk of numeric or structural chromosomal abnormality . An abnormal ratio of the CSP length and width is considered to be an indirect sign of partial agenesis of the corpus callosum (pACC) . However, different studies have used different techniques and planes to measure the CSP.…”

Section: Introductionmentioning

confidence: 99%

An investigation of the standardization of fetal cavum septi pellucidi measurements using three‐dimensional volumes of the fetal head

Zhao

Cai

Wang

2019

J of Clinical Ultrasound

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Purpose The purpose of this study was to measure the maximal width, middle width, and length of the cavum septi pellucidi (CSP) in normal fetuses, and compare these measurements obtained in the transthalamic (TT) plane with those obtained in the transventricular (TV) plane. Method A prospective study was conducted of normal singleton fetuses, ranging from 18 to 36 weeks in gestational age. In each case, a three‐dimensional volume of the fetal head was obtained in the TT plane for further offline measurements, then the maximal width, middle width, and length of the CSP in both the TT and TV planes were measured. Intraobserver and interobserver reproducibility was assessed, and curve estimation was used to assess the possible relationship between these measurements of CSP and gestational age (GA). Results A total of 267 normal fetuses were studied. The CSP width and length in TT and TV planes as a function of GA were analyzed using a quadratic regression model. Intraobserver and interobserver agreement of the CSP measurements was excellent overall (ICCs >0.9), with intraobserver and interobserver differences of less than 4%. Conclusion Measurements of CSP in the TT and TV planes are equally reproducible.

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Abnormal shape of the cavum septi pellucidi: an indirect sign of partial agenesis of the corpus callosum

Abstract: Objective To describe and assess the presence of a new indirect sign of partial agenesis of the corpus callosum (pACC): an abnormally shaped cavum septi pellucidi (CSP). Methods

Cited by 40 publications

References 16 publications

A new method for evaluating short fetal corpus callosum

A new method for evaluating short fetal corpus callosum

Utility of indirect sonographic signs (including cavum septum pellucidum ratio) in midgestational screening for partial agenesis of corpus callosum

An investigation of the standardization of fetal cavum septi pellucidi measurements using three‐dimensional volumes of the fetal head

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