Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia

Barbera, Roberta; Feinle, Christine; Read, N W

doi:10.1097/00042737-199511000-00007

Cited by 112 publications

(67 citation statements)

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“…[47][48][49][50] Other Mechanisms A number of other pathophysiologic mechanisms have been implicated in the pathophysiology of functional dyspepsia, based on limited numbers of studies, generally in small groups of patients. These include duodenal hypersensitivity to lipids, 51,52 increased duodenal acid exposure due to impaired duodenal clearance, 53,54 lack of postprandial suppression of phasic contractility of the proximal stomach, 55 and abnormalities of gastric electrical rhythm. 56,57 …”

Section: Helicobacter Pylori Infectionmentioning

confidence: 99%

Pathophysiology and treatment of functional dyspepsia

2004

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Section: Helicobacter Pylori Infectionmentioning

confidence: 99%

Pathophysiology and treatment of functional dyspepsia

2004

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“…Several pathophysiological causes of FD have been identified, such as delayed gastric emptying (Gilja et al, 1996;Quartero et al, 1998;Kusunoki et al, 2010;Karamanolis et al, 2006), abnormal antroduodenal motility (Stanghellini et al, 1992;Kusunoki et al, 2000), altered sensitivity to duodenal acid or lipid exposure (Burbera et al, 1995;Samson et al, 1999), visceral hypersensitivity (Mertz et al, 1998;Undeland et al, 1998), and impaired accommodation reflex (Salet et al, 1998;Tack et al, 1998). Among these, an impaired accommodation reflex is the most frequently observed pathophysiological condition in patients with FD.…”

Section: Figmentioning

confidence: 99%

Simple and non-invasive assessment of the accommodation reflex of the proximal stomach

Kusunoki

Haruma

Hara

et al. 2010

J Smooth Muscle Res

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Background: Impaired gastric accommodation of the proximal stomach is one of the major pathophysiological mechanisms in functional dyspepsia (FD). However, no useful method exists for the clinical evaluation of this phenomenon. Aim: The aim of the present study was to establish a simple and non-invasive method for evaluating the accommodation reflex of the proximal stomach. Methods: Nine healthy subjects received up to 1,700 mL water (stepwise administration in 100-mL increments) using a nasogastric tube while they were in a supine position. To assess the meal-induced gastric accommodation reflex, we measured the cross-sectional area of the proximal stomach via ultrasonography (US) at 3-min intervals after administration of water. We also measured the pressure of the water column using the same tube. Then, we administrated up to 400 mL of water in 100-mL increments and measured the area of the proximal stomach in 44 FD patients with early satiation (the measurements were performed at intervals of 3-min), and we compared the results with those for 44 healthy subjects. Results: The incremental changes in the area of the proximal stomach corresponded well with the amount of water administered. The area of the proximal stomach increased, but the antral area and the intragastric pressure remained relatively stable. After administration of more than 100 ml water, the area of the proximal stomach in healthy subjects was significantly greater than that in FD patients.

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Section: Helicobacter Pylori Infectionmentioning

confidence: 99%

Pathophysiology and Treatment of Functional Dyspepsia

Tack

Lee

2005

Journal of Clinical Gastroenterology

207

247

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Functional dyspepsia is a highly prevalent symptom complex and a heterogenous disorder. Recent studies showed potential associations between specific pathophysiologic disturbances and dyspeptic symptoms. Delayed gastric emptying reported in about 30% of patients with functional dyspepsia is associated with the symptoms of postprandial fullness, nausea, and vomiting. Impaired gastric accommodation present in 40% of functional dyspepsia patients is found to be associated with early satiety. Hypersensitivity to gastric distension is observed in 37% of functional dyspepsia patients and associated with the symptoms of postprandial pain, belching, and weight loss. Psychosocial factors and altered response to duodenal lipids or acid have also been identified as pathophysiologic mechanisms. Therapeutic options are still limited but targeted therapy directed at the underlying pathophysiology seems desirable. Thus, efforts to further elucidate underlying pathophysiologic mechanisms and identify the appropriate patient population using some type of pathophysiologic testing will be required.

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Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia

Cited by 112 publications

References 0 publications

Pathophysiology and treatment of functional dyspepsia

Pathophysiology and treatment of functional dyspepsia

Simple and non-invasive assessment of the accommodation reflex of the proximal stomach

Pathophysiology and Treatment of Functional Dyspepsia

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