Abnormal Scintigraphic Evolution in AA Hepatic Amyloidosis

Lomeña, Francisco; R, Roselló Pardo; Pons, F; Grau, M; Garcia, Armando L; Catafau, A; Setoain, J

doi:10.1097/00003072-198803000-00015

Cited by 5 publications

(1 citation statement)

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“…Recently, the extraskeletal uptake of 99mTc-pyrophosphate in the liver was reported, and it was concluded to be specific for hepatic amyloidosis 14,15. Of interest, the sites of the liver with comparatively remaining hepatocytes become hypertrophic, compared with the sites with hepatocytes compressed by severe deposition of amyloid 16…”

Section: Discussionmentioning

confidence: 99%

18F-fluorodeoxyglucose positron emission tomography might be useful for diagnosis of hepatic amyloidosis

Tawada¹,

Oide²,

Tsuyuguchi³

et al. 2014

IMCRJ

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We report on a woman with hepatic involvement of primary systemic (immunoglobulin light chain, AL) amyloidosis. Her diagnosis was confirmed by liver biopsy. Clinical symptoms of hepatic amyloidosis are generally mild at its first stage, with most frequent findings being hepatomegaly and alkaline phosphatase elevation. Recent advances in the understanding of the pathophysiology of systemic amyloidosis have made several treatments available. However, its prognosis is occasionally poor. Because liver biopsy is not always safe, other modalities for the diagnosis are needed. Of interest was that fluorodeoxyglucose (FDG) uptake into the liver was observed, compared with that into the spleen, in this patient, indicating that FDG positron emission tomography and computed tomography might be useful for the diagnosis of hepatic amyloidosis with mild liver dysfunction.

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Section: Discussionmentioning

confidence: 99%