Abnormal Savda Munziq, an Herbal Preparation of Traditional Uighur Medicine, May Prevent 1,2‐dimethylhydrazine‐Induced Rat Colon Carcinogenesis

Abstract

The study tried to assess the chemoprotective effect of abnormal Savda Munziq (ASMq) on 1,2-dimethylhydrazine (DMH)-induced rat colon carcinogenesis. Male F344 rats were randomized into eight groups: Group 1 was served as control, no DMH injection was given and treated daily with normal saline. Rats in Groups 2–8 were given a single intraperitoneal injection of DMH (20 mg/kg body weight) at the beginning of the study. Group 2 was served as negative control, administered with normal saline until the end of the experiment after the single DMH injection. Groups 3–5 were served as pretreatment group, administered with ASMq ethanol extract at 400, 800 and 1600 mg/kg body weight, respectively, until the 45th day, continued by normal saline administration for another 45 days. Groups 6–8 were served as the treatment group, administered with normal saline for the first 45 days from the day of DMH injection, ASMq ethanol extract at three different doses to be administered until the end of the second 45th day. All rats were sacrificed at 91st day and the colons were analyzed for aberrant crypt foci (ACF) formation and crypt multiplicity. Results showed that ASMq ethanol extract reduced the number of ACF, AC and crypt multiplicity significantly (P < .05). It suggested that ASMq ethanol extract had chemoprotective effects on DMH-induced colon carcinogenesis, by suppressing the development of preneoplastic lesions, and probably exerted protection against the initiation and promotion steps of colon carcinogenesis.

Attenuation effect of Abnormal Savda Munziq on liver and heart toxicity caused by chemotherapy in mice

“…Forst., Euphorbia maculata L., Foeniculum vulgare Mill., Glycyrrhiza glabra L., Lavandula angustifolia Mill., Melissa officinalis L., and Ziziphus jujuba Mill (14). ASMq has been applied to the prevention and treatment of numerous chronic diseases, including cancer, hypertension, diabetes mellitus and memory dysfunction (15).…”

“…In addition, ASMq has been shown to modulate cellular and humoral immunity in a combined stress mouse model, protecting mitochondria and DNA against damage induced by OH in a cell-free system (17,22). Furthermore, ASMq is able to inhibit cancer cell proliferation and viability in vitro (15,23,24), and has exhibited anti-tumor properties in vitro (15,(22)(23)(24) and in rats (25). However, its potential protective effects against toxicity induced by doxorubicin and 5-FU have not been systematically evaluated.…”

Effects of different doses of Savda Munziq on myocardial ischemia-reperfusion injury in rats with abnormal Savda syndrome

“…Our previous studies showed that the traditional Uygur medicine abnormal Savda Munziq, which is heading toward a modernized formula, showed good resistance to oxidation (Kizaibek et al, 2012) and had protective effects against oxidative DNA damage (Yusup et al, 2011). Experiments showed that the abnormal Savda Munziq not only had protective effects on the lipid peroxidation damage caused by free radicals, but also improved mitochondrial sodium oxide dismutase (SOD) and Ca 2+ -Mg 2+ -ATPase activities, and maintained the structural integrity of the mitochondrial membrane (Yusup et al, 2004).…”

Mechanisms of Hela Cell Apoptosis Induced by Abnormal Savda Munziq Total Phenolics Combined with Chemotherapeutic Agents

“…The Abnormal Savda Munziq (ASMq) is the valid prescription towards the treatment and prevention of various tumors in Uighur medicine, and its effects are significant (Yusup et al, 2005;Upur et al, 2011;Yusup et al, 2011;. Cisplatin and docetaxel are the commonly clinically used drugs in the treatment of gynec; ological malignant tumors, with exact efficacy (Wang et al, 2010;Ke et al, 2012;.…”