Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis

Liu, Jing; Cao, Lingxiao; Li, Hailong; Gao, Yingxue; Bu, Xuan; Liang, Kaili; Bao, Weijie; Zhang, Suming; Qiu, Hui; Xue, Li; Hu, Xinyue; Lu, Lu; Zhang, Lianqing; Huang, Xiaoqi; Gong, Qiyong

doi:10.1016/j.neubiorev.2022.104574

Cited by 44 publications

(29 citation statements)

References 92 publications

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“…As important brain regions of the fronto-limbic network, vmPFC, ACC, and amygdala showed no altered regional- and network-level brain activities at rest in patients with OCD in our research, which was inconsistent with previous findings [ 14 , 15 ]. Heterogeneity of clinical samples (i.e., sample sizes, comorbidity, and medication status) may explain these inconsistencies [ 34 ].…”

Section: Discussioncontrasting

confidence: 99%

“…Dysfunctional activities during emotional processing and increased activities during uncertainty and decision-making within the fronto-limbic network have been noted in OCD [ 2 , 12 , 13 ]. At the same time, hyperconnectivities within the fronto-limbic network (i.e., between caudate and orbital frontal cortex [OFC] and anterior cingulate cortex [ACC], and between vmPFC and ACC) have been discovered in OCD at rest [ 14 ]. Moreover, decreased amygdala-vmPFC functional connectivity and right amygdala degree centrality may predict a better outcome of cognitive behavior therapy in OCD [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Altered Regional Activity and Network Homogeneity within the Fronto-Limbic Network at Rest in Medicine-Free Obsessive–Compulsive Disorder

Chen

et al. 2022

Brain Sciences

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Functional abnormalities in brain areas within the fronto-limbic network have been widely reported in obsessive–compulsive disorder (OCD). However, region- and network-level brain activities of the fronto-limbic network at rest have not been simultaneously investigated in OCD. In this study, 40 medicine-free and non-comorbidity patients with OCD and 38 age-, education-, and gender-matched healthy controls (HCs) underwent a resting-state functional magnetic-resonance-imaging scan. Fractional amplitude of low-frequency fluctuations (fALFF), network homogeneity (NH), and support vector machine were used to analyze the data. Patients with OCD showed increased fALFF in the right orbital frontal cortex (OFC), increased NH in the left OFC, and decreased NH in the right putamen. Decreased NH of the right putamen was negatively correlated with the Y-BOCS total and compulsive behavior scores. Furthermore, a combination of NH in the left OFC and right putamen could be applied to differentiate OCD from HCs with optimum specificity and sensitivity. The current findings emphasize the crucial role of the fronto-limbic network in the etiology of OCD.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered Regional Activity and Network Homogeneity within the Fronto-Limbic Network at Rest in Medicine-Free Obsessive–Compulsive Disorder

Chen

et al. 2022

Brain Sciences

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Section: Structure and Function Of Neural Regions That May Be Connect...mentioning

confidence: 99%

“…Hyperconnectivity between the OFC and other brain regions can be seen in OCD and obesity ( Black et al, 2014 ; Liu et al, 2022 ). For example, OFC-ACC/and OFC-caudate hyperconnectivity has been documented in OCD ( Liu et al, 2022 ), and lateral OFC-left dorsolateral prefrontal cortex (dlPFC) hyperconnectivity in obese children when compared to controls ( Black et al, 2014 ). Hyperconnectivity between the vmPFC and striatum, frontal and motor cortices are also connected to OCD, with vmPFC-caudate hyperconnectivity being correlated with OCD severity ( Apergis-Schoute et al, 2018 ).…”

Section: Structure and Function Of Neural Regions That May Be Connect...mentioning

confidence: 99%

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

et al. 2022

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Decreased tolerance in response to specific every-day sounds (misophonia) is a serious, debilitating disorder that is gaining rapid recognition within the mental health community. Emerging research findings suggest that misophonia may have a unique neural signature. Specifically, when examining responses to misophonic trigger sounds, differences emerge at a physiological and neural level from potentially overlapping psychopathologies. While these findings are preliminary and in need of replication, they support the hypothesis that misophonia is a unique disorder. In this theoretical paper, we begin by reviewing the candidate networks that may be at play in this complex disorder (e.g., regulatory, sensory, and auditory). We then summarize current neuroimaging findings in misophonia and present areas of overlap and divergence from other mental health disorders that are hypothesized to co-occur with misophonia (e.g., obsessive compulsive disorder). Future studies needed to further our understanding of the neuroscience of misophonia will also be discussed. Next, we introduce the potential of neurostimulation as a tool to treat neural dysfunction in misophonia. We describe how neurostimulation research has led to novel interventions in psychiatric disorders, targeting regions that may also be relevant to misophonia. The paper is concluded by presenting several options for how neurostimulation interventions for misophonia could be crafted.

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“…The primary endpoint was measured by the changes from baseline in the Montgomery-Asber Depression Rating Scale (MADRS) total score over the 6-week treatment period calculated at each time point and averaged. The table below shows scores of the secondary endpoints with P-values for exemplary scale measured. …”

Section: Important Compound Classesmentioning

confidence: 99%

Potential Treatment for Obsessive-Compulsive Disorder

Kargbo

2022

ACS Med. Chem. Lett.

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Abnormal resting-state functional connectivity in patients with obsessive-compulsive disorder: A systematic review and meta-analysis

Cited by 44 publications

References 92 publications

Altered Regional Activity and Network Homogeneity within the Fronto-Limbic Network at Rest in Medicine-Free Obsessive–Compulsive Disorder

Altered Regional Activity and Network Homogeneity within the Fronto-Limbic Network at Rest in Medicine-Free Obsessive–Compulsive Disorder

The neurobiology of misophonia and implications for novel, neuroscience-driven interventions

Potential Treatment for Obsessive-Compulsive Disorder

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