Abnormal respiratory‐related evoked potentials in untreated awake patients with severe obstructive sleep apnoea syndrome

Donzel-Raynaud, Christine; Redolfi, Stefania; Arnulf, Isabelle; Similowski, Thomas; Straus, Christian

doi:10.1111/j.1475-097x.2008.00830.x

Cited by 20 publications

(14 citation statements)

References 36 publications

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“…or not evaluated at all. Excluding the four pediatric studies: in one report patients were included that were likely to be affected by OSAS but the disturbed breathing was not recorded (Wong et al , 2006 ), three did not clearly specify the degree of OSAS (Walsleben et al , 1989 ;Rumbach et al , 1991 ), three included mild OSAS (one of which together with severe OSAS) (Gora et al , 2002 ;Zhang et al , 2002 ;Afi fi et al , 2003 ), eight papers included rather severe OSAS patients (Kotterba et al , 1998 ;Delgado Rodrigues et al , 2006 ;Gosselin et al , 2006a,b ;Sforza and Haba -Rubio, 2006 ;Donzel -Raynaud et al, 2009 ;Neu et al , 2011 ) and fi ve included individuals with different degrees of severity of OSAS, ranging from mild to severe Sangal , 1995, 1997a,b,c ;Inoue et al , 2001 ).…”

Section: Discussionmentioning

confidence: 99%

“…In particular, Gora et al ( 2002) and Afi fi et al (2003) found an altered response to the respiratory occlusion stimulus in adults with OSAS during non-REM sleep stage 2, that they indicated as being ' blunted ' . In contrast, delayed N1, P2, N2 components without alterations in amplitude were found during wakefulness (Donzel -Raynaud et al, 2009 ).…”

Section: A Short Essay On Respiratory-related Evoked Potentialsmentioning

confidence: 93%

“…Some studies with RREPs were carried out both in adults and children with OSAS (Gora et al , 2002 ;Afi fi et al , 2003 ;Huang et al , 2008a,b ;Donzel -Raynaud et al, 2009 ) which showed signifi cant abnormalities during both sleep and wakefulness. In particular, Gora et al ( 2002) and Afi fi et al (2003) found an altered response to the respiratory occlusion stimulus in adults with OSAS during non-REM sleep stage 2, that they indicated as being ' blunted ' .…”

Section: A Short Essay On Respiratory-related Evoked Potentialsmentioning

confidence: 98%

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Cognitive evoked potentials in obstructive sleep apnea syndrome: a review of the literature

Raggi

Ferri

2012

Reviews in the Neurosciences

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Cognitive functions may be altered in patients with obstructive sleep apnea syndrome (OSAS) and it has been proposed that vigilance and attention changes play a fundamental role in all aspects of cognitive deficits noted in this disease. The use of event-related potentials (ERPs) is a high-time resolution technique that can be used to explore the presence of cognitive dysfunction. We review 23 empirical articles on ERPs in OSAS in order to contribute to the clarification of the pattern of cognitive deficits that are specific to this disease and to see whether there might be an improvement of abnormal psychophysiological findings with continuous positive airway pressure (CPAP) treatment. We conclude that ERP studies have contributed to demonstrating changes in cognitive attentive processing in OSAS, mainly in association with altered functioning of the prefrontal cortex, and that CPAP treatment may improve vigilance and attention and generally improve cerebral information processing in these patients. The remaining deficits during sufficient CPAP therapy may, however, reflect irreversible hypoxic cerebral damage.

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Section: Discussionmentioning

confidence: 99%

Section: A Short Essay On Respiratory-related Evoked Potentialsmentioning

confidence: 93%

Section: A Short Essay On Respiratory-related Evoked Potentialsmentioning

confidence: 98%

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Cognitive evoked potentials in obstructive sleep apnea syndrome: a review of the literature

Raggi

Ferri

2012

Reviews in the Neurosciences

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“…Consistent with impaired sensory transmission to respiratory stimuli, two studies revealed a reduction in the amplitude but not the latency of the early RREP components to brief negative pressures during inspiration (Akay et al, 2003) and expiration (Grippo et al, 2011). However, other studies have shown no difference in P1 amplitude or latency (reflecting the arrival of the sensory information to the cortex) of the RREP to inspiratory occlusions and negative pressures in OSA patients (Gora et al, 2002; Afifi et al, 2003; Donzel-Raynaud et al, 2009; Eckert et al, 2011). During sleep, P1 does not appear to be different between OSA patients and controls (Gora et al, 2002; Afifi et al, 2003).…”

Section: Evidence For Upper Airway Afferent Changesmentioning

confidence: 95%

Functional Role of Neural Injury in Obstructive Sleep Apnea

Saboisky¹,

Butler²,

Gandevia³

et al. 2012

Front. Neur.

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The causes of obstructive sleep apnea (OSA) are multifactorial. Neural injury affecting the upper airway muscles due to repetitive exposure to intermittent hypoxia and/or mechanical strain resulting from snoring and recurrent upper airway closure have been proposed to contribute to OSA disease progression. Multiple studies have demonstrated altered sensory and motor function in patients with OSA using a variety of neurophysiological and histological approaches. However, the extent to which the alterations contribute to impairments in upper airway muscle function, and thus OSA disease progression, remains uncertain. This brief review, primarily focused on data in humans, summarizes: (1) the evidence for upper airway sensorimotor injury in OSA and (2) current understanding of how these changes affect upper airway function and their potential to change OSA progression. Some unresolved questions including possible treatment targets are noted.

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“…The respiratory-related evoked potentials (RREPs) during wakefulness in OSA revealed a reduction in the amplitude but not the latency of the early RREP components [44,47] reflecting sensory processing is reduced in the OSA patients [48]. Other studies revealed no changes [49][50][51].…”

Section: Sleep Apnea -Recent Updatesmentioning

confidence: 99%

Nerve and Muscle Changes in the Upper Airways of Subjects with Obstructive Sleep Apnea: Structural Basis for the Neurogenic Theory

Cobo¹,

Macías²,

Alvarez³

et al. 2017

Sleep Apnea - Recent Updates

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Obstructive sleep apnea syndrome (OSAS) is a widely diffused disease associated with specific genetics, age, gender, craniofacial and upper airways anatomy, obesity, and endocrine conditions, but not with ethnicity profiles. The so-called neurogenic neurogenic theory of OSAS postulates that the collapse of the upper airways that characterize this disease is due to peripheral nerve degeneration that leads to muscle atrophy and collapse. This review attempts to summarize the structural and functional changes in both the sensory and motor innervation of the walls of the upper air ways in patients suffering from OSAS.

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Abnormal respiratory‐related evoked potentials in untreated awake patients with severe obstructive sleep apnoea syndrome

Abstract: The cortical processing of airway occlusion-related afferents seems abnormal in untreated patients with severe obstructive sleep apnoea syndrome. This could be either a severity marker and/or an aggravating factor.

Cited by 20 publications

References 36 publications

Cognitive evoked potentials in obstructive sleep apnea syndrome: a review of the literature

Cognitive evoked potentials in obstructive sleep apnea syndrome: a review of the literature

Functional Role of Neural Injury in Obstructive Sleep Apnea

Nerve and Muscle Changes in the Upper Airways of Subjects with Obstructive Sleep Apnea: Structural Basis for the Neurogenic Theory

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