Abnormal release of nitric oxide from nitrosoprotein in preeclampsia

Terán, Enrique; Escudero, Carlos; Moya, Walter

doi:10.1016/j.ijgo.2005.12.015

Cited by 11 publications

(7 citation statements)

References 4 publications

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“…Although this is in agreement with our previous observations [12][13][14][15], the reported levels of NO in relation to pre-eclampsia are contradictory [16], which is probably due to differences in the measurement methods and/or the metabolite analyzed. Nevertheless, there is agreement that pre-eclampsia is associated with altered NO production and/or activity.…”

Section: Discussionsupporting

confidence: 91%

Plasma and placental nitric oxide levels in women with and without pre‐eclampsia living at different altitudes

Terán

Chedraui

Vivero

et al. 2008

Intl J Gynecology & Obste

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Section: Discussionsupporting

confidence: 91%

Plasma and placental nitric oxide levels in women with and without pre‐eclampsia living at different altitudes

Terán

Chedraui

Vivero

et al. 2008

Intl J Gynecology & Obste

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“…In the sample of studies we assessed, usually most sampling was performed either in serum or plasma and detection method of choice was the Greiss method with the exception of three studies which used a Siever's Nitric Oxide Analyzer or GC-MS. As a general trend, most studies showed that · NO levels were significantly lower in preeclamptic than normotensive women (Seligman et al, 1994 ; Baker et al, 1995 ; Davidge et al, 1996 ; Nobunaga et al, 1996 ; Pathak et al, 1999 ; Nishikawa et al, 2000 ; Shaamash et al, 2000 ; Vural, 2002 ) with a few exceptions in where levels were not significantly different (Lyall et al, 1995 ; Conrad et al, 1999 ; Diejomaoh et al, 2004 ). Studies from Ecuador, Brazil and China, have shown that · NO levels were significantly lower in preeclamptic than normotensive women (Teran et al, 2006 ; Mao et al, 2010 ; Sandrim et al, 2010 ). This latter studies were performed using more sensitive and selective techniques like a Siever's Nitric Oxide Analyzer or GC-MS.…”

Section: Role Of · No and Nitric Oxide Synthase (Nmentioning

confidence: 99%

Endothelial dysfunction and preeclampsia: role of oxidative stress

et al. 2014

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Preeclampsia (PE) is an often fatal pathology characterized by hypertension and proteinuria at the 20th week of gestation that affects 5–10% of the pregnancies. The problem is particularly important in developing countries in where the incidence of hypertensive disorders of pregnancy is higher and maternal mortality rates are 20 times higher than those reported in developed countries. Risk factors for the development of PE include obesity, insulin resistance and hyperlipidemia that stimulate inflammatory cytokine release and oxidative stress leading to endothelial dysfunction (ED). However, how all these clinical manifestations concur to develop PE is still not very well understood. The related poor trophoblast invasion and uteroplacental artery remodeling described in PE, increases reactive oxygen species (ROS), hypoxia and ED. Here we aim to review current literature from research showing the interplay between oxidative stress, ED and PE to the outcomes of current clinical trials aiming to prevent PE with antioxidant supplementation.

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“…An important body of evidence suggests that an increased endothelial NO production is implicated in normal pregnant vasodilation [Williams et al 1997]. Table 1 summarizes some of the studies demonstrating that the production of NO, evaluated by the plasma and serum levels of NO 2 and NO 3 [Schiessl et al 2006;Teran et al 2006;D'Anna et al 2004;Diejomaoh et al 2004;Makkonen et al 2002;Vural, 2002;Yoneyama et al 2002;Nishikawa et al 2000;Shaamash et al 2000;Conrad et al 1999;Egerman et al 1999;Hata et al 1999;Lopez-Jaramillo et al 1992], the bioactivity of NO evaluated by cGMP levels in biological fluids or in platelets [Baksu et al 2005;Teran et al 2004;Shaamash et al 2000;Conrad et al 1999;Lopez-Jaramillo et al 1996;Schneider et al 1996;] and, the biological effect of NO in the vasculature, evaluated by flowmediated vasodilation (FMD) [Saarelainen et al 2006;Sierra-Laguado et al 2006;Yamamoto et al 2005;Savvidou et al 2000;Dorup et al 1999;Cockell and Poston, 1997], are all increased in normal pregnant women, in relation with normotensive nonpregnant women. Thus, nowadays, there is no doubt that an increased production of NO in the vascular endothelium and a normal bioactivity of NO are the critical mechanisms that explain the hemodynamical adaptations during pregnancy.…”

Section: Hemodynamic Changes In Normal Pregnancymentioning

confidence: 99%

Review: The role of the L-arginine-nitric oxide pathway in preeclampsia

López‐Jaramillo

Arenas

García

et al. 2008

Therapeutic Advances in Cardiovascular Disease

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Preeclampsia (PE) is a major cause of maternal and perinatal mortality, especially in developing countries. Its etiology involves multiple factors, but no specific cause has been identified. Evidence suggests that clinical manifestations are caused by endothelial dysfunction. Nitric oxide (NO), which is synthesized from L-arginine in endothelial cells by the endothelial nitric oxide synthase (eNOS), provides a tonic dilator tone and regulates the adhesion of white blood cells and platelet aggregation. Alterations in the L-arginine-NO pathway have been associated with the development of PE. Various studies, reporting decreased, elevated or unchanged levels of nitrite (NO(2)) and nitrate (NO(3)), two end products of NO metabolism, have been published. Our group contributed to those contradictory reports describing cases of PE with both elevated and decreased levels of NO(2) and NO(3). Apparently, diminished levels of NO could be related to deficiencies in the ingestion of dietary calcium associated to low levels of plasma ionic calcium, which is crucial to the eNOS' activity. Also, low levels of NO could be associated with the presence of eNOS polymorphisms or the presence of increased levels of ADMA, the endogenous inhibitor of NO. High levels of NO associated to low levels of cGMP suggest a decreased bioactivity of NO, which is probably related to an increased degradation of NO caused by a high production of superoxide in states of infection and inflammation. The present article analyses and reviews the reported paradoxical roles of the L-arginine-NO pathway in PE and gives a possible explanation for these results.

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Abnormal release of nitric oxide from nitrosoprotein in preeclampsia

Cited by 11 publications

References 4 publications

Plasma and placental nitric oxide levels in women with and without pre‐eclampsia living at different altitudes

Plasma and placental nitric oxide levels in women with and without pre‐eclampsia living at different altitudes

Endothelial dysfunction and preeclampsia: role of oxidative stress

Review: The role of the L-arginine-nitric oxide pathway in preeclampsia

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