Abnormal proliferation of CD4? CD8+ ??+ T cells with chromosome 6 anomaly: Role of fas ligand expression in spontaneous regression of the cells

Ichikawa, Naoaki; Kitano, Kiyoshi; Ito, Toshiro; Nakazawa, Tomoyuki; Shimodaira, Shigetaka; Ishida, Fumihiro; Kiyosawa, Kendo

doi:10.1002/(sici)1096-8652(199904)60:4<305::aid-ajh9>3.0.co;2-6

Cited by 8 publications

(4 citation statements)

References 18 publications

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“…An extensive review of previous reports shows that a total of 24 cases with γ δ T‐LDGL, including our report, have been identified (4, 5, 14, 22–24, 34–45). Fourteen of them were Japanese, although no cases were reported from other parts of Asia.…”

Section: Discussionmentioning

confidence: 64%

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Lymphoproliferative disease of granular lymphocytes with T‐cell receptor gamma delta‐positive phenotype: restricted usage of T‐cell receptor gamma and delta subunit genes

Makishima

Ishida

Saitô

et al. 2003

European J of Haematology

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Lymphoproliferative disease of granular lymphocytes (LDGL) is characterized by more than 0.5 x 109/L of proliferating granular lymphocytes in the peripheral blood. Because of its rarity, the characteristics of LDGL with T-cell receptor (TCR) gammadelta phenotype (gammadeltaT-LDGL) have not yet been identified. This report describes the clinical, hematological, and immunological findings of four patients with this disease. In two cases, the clinical course was indolent and the other two patients required various therapies. The cells had a common immunophenotype: CD3+, CD4-, CD16+, CD56-, CD57-, CD122-, TCR-gammadelta+, and three were CD8-positive. The immunopurified TCR-gammadelta cells from the patients expressed only Vgamma9 and Vdelta1. Spectratyping and sequencing showed mono- or oligoclonality for TCRgamma and TCRdelta subunit genes. Soluble Fas ligand in sera was significantly elevated in all patients. These findings suggest that gammadeltaT-LDGL qualifies as a distinct disease entity.

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Section: Discussionmentioning

confidence: 64%

“…Patient 2 was the subject of a previous report by Ichikawa et al . (14). All samples were obtained under written informed consent.…”

Section: Casesmentioning

confidence: 99%

Lymphoproliferative disease of granular lymphocytes with T‐cell receptor gamma delta‐positive phenotype: restricted usage of T‐cell receptor gamma and delta subunit genes

Makishima

Ishida

Saitô

et al. 2003

European J of Haematology

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“…The clinical findings of the individuals with T cell‐type LDGL are shown in Table I. The detailed characterization of cases 6 and 7 was previously described by Shimodaira et al (1995) and that of case 12 by Ichikawa et al (1999). Among the 14 patients, expanding LGL cells of 11 were positive for the expression of TCR αβ chains (nine were CD4 – CD8 + , one was CD4 + CD8 – and the other was CD4 + CD8 + ) whereas three were positive for TCR γδ.…”

Section: Resultsmentioning

confidence: 91%

DNA microarray analysis of T cell‐type lymphoproliferative disease of granular lymphocytes

et al. 2002

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Summary. Lymphoproliferative disease of granular lymphocytes (LDGL) is characterized by the clonal proliferation of large granular lymphocytes of either T-or natural killer cell origin. To better understand the nature of T celltype LDGL, we purified the CD4 -CD8 + proliferative fractions from LDGL patients (n ¼ 4) and the surface marker-matched T cells isolated from healthy volunteers (n ¼ 4), and compared the expression profiles of 3456 genes using DNA microarray. Through this analysis, we identified a total of six genes whose expression was active in the LDGL T cells, but silent in the normal ones. Interestingly, expression of the gene for interleukin (IL) 1b was specific to LDGL T cells, which was further confirmed by the examination of the serum level of IL-1b protein. Given its important role in inflammatory reactions, the disease-specific expression of IL-1b may have a causative relationship with the LDGLassociated rheumatoid arthritis. Spectratyping analysis of the T-cell receptor repertoire also proved the monoclonal or oligoclonal nature of LDGL cells. These data have shown that microarray analysis with a purified T-cell subset is an efficient approach to investigate the pathological condition of T cell-type LDGL.

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“…However, our two cases and a review of the literature on this topic suggest that γδ T-LGL leukemia is usually indolent and rarely may even spontaneously regress [17]. …”

Section: Commentmentioning

confidence: 99%

The γδ variant of T cell large granular lymphocyte leukemia is very similar to the common αβ type: report of two cases

Shaw

Naik

2008

J Hematopathol

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The vast majority of cases of T cell large granular lymphocyte (T-LGL) leukemia have a CD3+, CD4−, CD8+ phenotype and express the αβ T cell receptor. Whether the rare γδ variant should be included in the same diagnostic category is currently unclear. Two well-characterized cases of γδ T-LGL leukemia were identified by our laboratory in 2007. These two cases and other reports of γδ T-LGL leukemia were compared with the common αβ variant. Other than more often being negative for both CD4 and CD8 (in about 35% to 40% of cases), the γδ variant of T-LGL leukemia is similar to the common αβ type in virtually all respects and should be included in the general category of T-LGL leukemia. However, it is important to exclude other more aggressive γδ T cell lymphoproliferative disorders.

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Abnormal proliferation of CD4? CD8+ ??+ T cells with chromosome 6 anomaly: Role of fas ligand expression in spontaneous regression of the cells

Cited by 8 publications

References 18 publications

Lymphoproliferative disease of granular lymphocytes with T‐cell receptor gamma delta‐positive phenotype: restricted usage of T‐cell receptor gamma and delta subunit genes

Lymphoproliferative disease of granular lymphocytes with T‐cell receptor gamma delta‐positive phenotype: restricted usage of T‐cell receptor gamma and delta subunit genes

DNA microarray analysis of T cell‐type lymphoproliferative disease of granular lymphocytes

The γδ variant of T cell large granular lymphocyte leukemia is very similar to the common αβ type: report of two cases

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