Abnormal Patterns of Growth and Development in Mongolism

Thelander, H. E.; Pryor, Helen B.

doi:10.1177/000992286600500812

Cited by 52 publications

(17 citation statements)

References 12 publications

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“…The short stature of the Down's child has in part been attributed to their relatively short leg length (Talbot, 1924;Thelander and Prior, 1966). The relatively shorter legs of our sample of Down's children in comparison to their normal counterparts is indicated by the consistently higher sitting height/standing height indices of the former as compared to the latter.…”

Section: Discussionmentioning

confidence: 74%

Observations From Longitudinal Data on Growth in Stature and Sitting Height of Children With Down's Syndrome*

Rarick

Seefeldt

1974

J intellect Disabil Res

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Section: Discussionmentioning

confidence: 74%

Observations From Longitudinal Data on Growth in Stature and Sitting Height of Children With Down's Syndrome*

Rarick

Seefeldt

1974

J intellect Disabil Res

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“…1). Although craniofacial effects are an invariant aspect of DS, a great amount of individual metric variation in these craniofacial features and in other metric phenotypes has been reported among DS individuals [Kisling, 1966;Thelander and Pryor, 1966;Frostad et al, 1971;Cronk and Reed, 1981].…”

Section: Introductionmentioning

confidence: 99%

Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome

et al. 2001

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Trisomy for chromosome 21 (Chr 21) has profound effects on development that result in a constellation of phenotypes known as Down syndrome (DS). Distinctive craniofacial manifestations are among the few features common to all individuals with DS. The characteristic face of a person with DS results primarily from maldevelopment of the underlying craniofacial skeleton. The Ts65Dn mouse, which has segmental trisomy 16, producing dosage imbalance for about half the genes found on human Chr 21, exhibits specific skeletal malformations corresponding directly to the craniofacial dysmorphogenesis in DS. Here we demonstrate that Ts1Cje mice, which are at dosage imbalance for about 3/4 of the genes triplicated in Ts65Dn, demonstrate a very similar pattern of anomalies in the craniofacial skeleton. However, one characteristic of Ts65Dn mice, a broadening of the cranial vault contributing to brachycephaly, is not seen in Ts1Cje mice. These observations independently confirm that a dosage imbalance for mouse genes orthologous to those on human Chr 21 has corresponding effects in both species. The subtle differences in the craniofacial phenotypes of Ts1Cje and Ts65Dn mice have implications for elucidation of the mechanisms by which this aneuploidy disrupts development.

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“…Height and weight reference curves for children with DS have recently been published [Cronk et al, 19881. While several other published studies concerning DS include head circumference measurements [Mosier et al, 1965;Thelander and Pryor, 1966;Pryor and Thelander, 1967;Pueschel, 1984;Ershow, 1986;Wisniewski et al, 1987;Sharav et al, 1988;Wisniewski, 19901, none had generated head circumference reference curves either appropriate for use by or widely available to physicians and other health care professionals following children with DS.…”

Section: Introductionmentioning

confidence: 99%

Head circumference of children with Down syndrome (0–36 months)

et al. 1992

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This study provides statistically appropriate head circumference reference curves for males and females with Down syndrome (DS) from birth to 36 months of age. A total of 239 males and 182 females from five study populations, yielding a combination of cross-sectional and longitudinal data, were used for the analysis. The method of least squares was used to test the fit of the growth model y = a+bx+c[log(x + 1)], where x is age in months. These standardized curves should provide information of value in the medical, physical, and developmental management of children with DS.

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Abnormal Patterns of Growth and Development in Mongolism

Cited by 52 publications

References 12 publications

Observations From Longitudinal Data on Growth in Stature and Sitting Height of Children With Down's Syndrome*

Observations From Longitudinal Data on Growth in Stature and Sitting Height of Children With Down's Syndrome*

Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome

Head circumference of children with Down syndrome (0–36 months)

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