Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test

Papageorgiou, Charalabos; Liappas, Ioannis; Asvestas, Pantelis A.; Vasios, Christos E.; Matsopoulos, George K.; Nikolaou, Chrysoula; Nikita, Konstantina S.; Uzunoglu, N.K.; Rabavilas, Andreas D.

doi:10.1097/00001756-200106130-00051

Cited by 29 publications

(33 citation statements)

References 21 publications

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“…The prolongation of ERP components latencies in heroin addicts was also reported (Bauer, 1998;Arzumanov, 2001;Papageorgiou et al, 2001), and the delay in N75 latency significantly correlated with years of heroin use, but not with abstinence length in the study of Bauer (1998).…”

Section: Eeg Studies In Heroin Abuserssupporting

confidence: 66%

“…In the study of Papageorgiou et al (2001) latency of component P600 was significantly prolonged only in right derivations, most prominently at Fp2 and at the half way between C4/T6. The latter finding was observed in heroin ex-addicts who maintained complete abstinence for at least 6 months.…”

Section: Lateralized Brain Dysfunction In Chronic Heroin Abusersmentioning

confidence: 79%

“…Most studies showed considerable or even complete normalization of EEG spectral power or amplitude of ERP components in heroin ex-addicts who maintained abstinence for at least three months (Shufman et al, 1996;Costa and Bauer, 1997;Bauer, 2001;Papageorgiou et al, 2001;Bauer, 2002).…”

Section: Eeg Studies In Heroin Abusersmentioning

confidence: 99%

“…Two research groups reported prolongation of latencies of cognitive ERP predominantly in the right hemisphere in heroin addicts (Arzumanov, 2001;Papageorgiou et al, 2001). In the study of Papageorgiou et al (2001) latency of component P600 was significantly prolonged only in right derivations, most prominently at Fp2 and at the half way between C4/T6.…”

Section: Lateralized Brain Dysfunction In Chronic Heroin Abusersmentioning

confidence: 99%

“…Indeed, opiate addicts who maintain medication free abstinence for several months often do not demonstrate global brain function deficits when neuropsychological or electroencephalographic measures are used (Bruhn and Maage, 1975;Shufman et al, 1996;Costa and Bauer, 1997;Bauer, 1998;Davis et al, 2002), nevertheless, two studies demonstrated persisting prefrontal dysfunction in heroin ex-addicts who had been completely withdrawn from the drugs for three and more months (Papageorgiou et al, 2001;Lee and Pau, 2002). Hence, the existing data evidence, that chronic heroin abusers are characterized by 'focal' prefrontal rather than diffuse brain dysfunction.…”

Section: Introductionmentioning

confidence: 99%

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Heroin abusers' performance on the Tower of London Test relates to the baseline EEG alpha2 mean frequency shifts

Davydov¹,

Polunina²

2004

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Planning function deficit is a most consistent finding in neuropsychological studies of heroin addicts. The performance on the Tower of London Test (TLT) correlated with the duration of daily heroin abuse (DDHA) in our previous study. Alpha2 mean frequency in anterior/central derivations was also predicted by DDHA in the same patient population. This retrospective study was undertaken in order to understand better the relationships between observed neurological deviations in heroin abusers.Thirty three heroin addicts and 12 healthy males were evaluated with 14 neuropsychological tests and resting eyes closed EEG. Multivariate tests showed that performance on the difficult (5 move) problems of TLT was strongly predicted by the EEG alpha2 mean frequency shifts, and these relationships were generally mediated by chronic heroin length. However, post-hoc analyses at separate leads demonstrated that the relationships between cognitive variables and alpha2 mean frequencies at left hemisphere were independent from chronic heroin effects, whereas elevation of alpha2 frequency in right hemisphere was strongly predicted by chronic heroin intake length. The patients with extremely high alpha2 mean frequency at left central region were especially prone to failure in TLT, that might be due to the inability of the hypothesized alpha2 generating network, which normally projecting to the central and temporal derivations bilaterally and to the right posterior temporal derivation, to function appropriately. Hence, it was concluded that planning dysfunction in heroin abusers is related to alpha2 mean frequency shifts predominantly at central regions.

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Section: Eeg Studies In Heroin Abuserssupporting

confidence: 66%

Section: Lateralized Brain Dysfunction In Chronic Heroin Abusersmentioning

confidence: 79%

Section: Eeg Studies In Heroin Abusersmentioning

confidence: 99%

Section: Lateralized Brain Dysfunction In Chronic Heroin Abusersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Heroin abusers' performance on the Tower of London Test relates to the baseline EEG alpha2 mean frequency shifts

Davydov¹,

Polunina²

2004

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Neuroelectrophysiological approaches in heroin addiction research: A review of literatures

Motlagh

Ibrahim

Menke

et al. 2016

J of Neuroscience Research

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Neuroelectrophysiological properties have been used in human heroin addiction studies. These studies vary in their approach, experimental conditions, paradigms, and outcomes. However, it is essential to integrate previous findings and experimental methods for a better demonstration of current issues and challenges in designing such studies. This Review examines methodologies and experimental conditions of neuroelectrophysiological research among heroin addicts during withdrawal, abstinence, and methadone maintenance treatment and presents the findings. The results show decrements in attentional processing and dysfunctions in brain response inhibition as well as brain activity abnormalities induced by chronic heroin abuse. Chronic heroin addiction causes increased β and α2 power activity, latency of P300 and P600, and diminished P300 and P600 amplitude. Findings confirm that electroencephalography (EEG) band power and coherence are associated with craving indices and heroin abuse history. First symptoms of withdrawal can be seen in high-frequency EEG bands, and the severity of these symptoms is associated with brain functional connectivity. EEG spectral changes and event-related potential (ERP) properties have been shown to be associated with abstinence length and tend to normalize within 3-6 months of abstinence. From the conflicting criteria and confounding effects in neuroelectrophysiological studies, the authors suggest a comprehensive longitudinal study with a multimethod approach for monitoring EEG and ERP attributes of heroin addicts from early stages of withdrawal until long-term abstinence to control the confounding effects, such as nicotine abuse and other comorbid and premorbid conditions.

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Investigation of brain electrophysiological properties among heroin addicts: Quantitative EEG and event‐related potentials

Motlagh

Ibrahim

Rashid

et al. 2016

J of Neuroscience Research

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This study aims to introduce a new approach of a comprehensive paradigm to evaluate brain electrophysiological properties among addicts. Electroencephalographic spectral power as well as amplitudes and latencies of mismatch negativity (MMN), P300, and P600 components were evaluated among 19 male heroin addicts and 19 healthy nonsmoker subjects using a paradigm consisting of three subparadigms, namely (1) digit span Wechsler test, (2) auditory oddball, and (3) visual cue-reactivity oddball paradigms. Task 1 provided auditory P300 and P600 in association with working memory. Task 2 provided auditory P300 as well as small and large deviant MMN event-related potential (ERPs). Finally, task 3 provided visual cue-reactivity P300. Results show that beta power was higher among heroin addicts while delta, theta, and alpha powers were decreased compared with healthy subjects. ERP analysis confirmed the decline of brain-evoked potential amplitudes when compared with healthy subjects, thus indicating a broad neurobiological vulnerability of preattentive and attentional processing including attentional deficits and compromise of discrimination abilities. The prolonged latency of ERPs reflects poor cognitive capacity in the engagement of attention and memory resources. On the other hand, an increase of attention towards the heroin-related stimuli could be concluded from the increase of P300 in the cue-reactivity condition among heroin addicts. Findings suggest that applying this paradigm in addiction studies benefits comprehensive evaluation of neuroelectrophysiological activity among addicts, which can promote a better understanding of drugs' effects on the brain as well as define new neuroelectrophysiological characteristics of addiction properties. © 2016 Wiley Periodicals, Inc.

show abstract

Abnormal P600 in heroin addicts with prolonged abstinence elicited during a working memory test

Cited by 29 publications

References 21 publications

Heroin abusers' performance on the Tower of London Test relates to the baseline EEG alpha2 mean frequency shifts

Heroin abusers' performance on the Tower of London Test relates to the baseline EEG alpha2 mean frequency shifts

Neuroelectrophysiological approaches in heroin addiction research: A review of literatures

Investigation of brain electrophysiological properties among heroin addicts: Quantitative EEG and event‐related potentials

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