Abnormal neural activity of brain regions in treatment-resistant and treatment-sensitive major depressive disorder: A resting-state fMRI study

Resting-state brain activation correlates with short-time antidepressant treatment outcome in drug-naïve patients with major depressive disorder

“…This is in accordance with other neuroimaging studies, suggesting that functional differences may be present specifically in patients rather than in healthy controls. 32,15 Studies comparing patients and healthy subjects naturally reflect the differences related to pathological changes, and it remains unclear as to whether these brain regions may represent new treatment targets. A cross-sectional and longitudinal study reported that the ALFF approach for identifying abnormal brain regions was inconsistent.…”

“…15 To the best of our knowledge, there have been no studies investigating brain function in the early phase of treatment (2 weeks).…”

Voxel-wise meta-analyses of brain blood flow and local synchrony abnormalities in medication-free patients with major depressive disorder

“…If the ar ticles were written in other languages, they were translated into English for assessment. In all, 5 SPECT studies, 8,9,[33][34][35] 8 PET studies, 6,7,36-41 1 ASL study 10 and 9 regional homogeneity studies [11][12][13]17,[42][43][44][45][46] met our inclusion criteria (Table 1). All these papers were written in English.…”

Alteration of spontaneous neuronal activity in young adults with non-clinical depressive symptoms

“…Of note, FC methods measure the relation between different regions rather than blood oxygenation level dependent (BOLD) signal changes related to the regional spontaneous activity (Zou et al, 2008). For example, abnormal FC within regions does not indicate that the ROI is abnormal (Guo et al, 2012). In addition, a newly developed approach, called Regional Homogeneity (ReHo), uses time series of a given voxel compared with those of its nearest voxels, which creates a temporal activation map of the whole brain.…”