Abnormal muscle metaboreflex control of ventilation in patients with chronic obstructive pulmonary disease: what mechanisms should be blamed?

Aranda, Liliane Cunha; Sabino‐Carvalho, Jeann L.; Miranda-Silva, Talita; Paula‐Ribeiro, Marcelle

doi:10.1113/jp273462

Cited by 3 publications

(3 citation statements)

References 5 publications

(12 reference statements)

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“…One hypothesis to explain difficulties in gait capacity is precisely related to ventilatory limitations found in this sample. The neural activity for respiratory muscles and other noble body functions may trigger neuromotor detachment, redirecting energy from peripheral motor activity to essential functions, such as breathing and heartbeat [ 62 ]. People with PD possibly have neuromotor detachment as well in situations that require a combined motor and cardiorespiratory responses, as in submaximal tests like 6 MWT.…”

Section: Discussionmentioning

confidence: 99%

“…People with PD possibly have neuromotor detachment as well in situations that require a combined motor and cardiorespiratory responses, as in submaximal tests like 6 MWT. This occurs mainly due to cardiorespiratory complications, with inefficient gaseous exchange incapable of maintaining O 2 and CO 2 homeostasis—which commonly occurs in increased dead space, pulmonary hyperinflation, and chronic obstructive pulmonary disease [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

“…ey can even make movements that would not be possible on land because of the action of forces, especially gravity. Hence, in the therapeutic pool, PD patients explore and activate neuromotor pathways that aid in motor learning and compensation, especially when there are neurofunctional sequelae [40,[45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64].…”

Section: Discussionmentioning

confidence: 99%

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Effects of an Aquatic Physical Exercise Program on Ventilatory Parameters in People with Parkinson’s Disease

Yamaguchi

Iucksch

Paladini

et al. 2022

Parkinson's Disease

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Problems in the respiratory system are the main cause of death in Parkinson’s disease (PD). Ventilatory limitations can also be part of a vicious cycle involving physical-functional limitations (e.g., walking difficulties) and the patients’ perception of fatigue. The objective of this study was to analyze the effects of an aquatic physical exercise intervention program on ventilatory parameters, perception of fatigue, and gait capacity in participants with PD. This quasi-experimental study had a single group with repeated measures in four assessments, proposing an aquatic physical exercise intervention program. The inclusion criteria encompassed being in levels 1 to 4 on the Hoehn and Yahr scale and having a medical certificate for the activities. Assessments took place at 3-month intervals between them—the first period was the control, the second following the intervention, and the third period was the follow-up. The intervention had 25 biweekly sessions over 3 months. A total of 13 people (71.3 ± 5.61 years old) participated in the intervention, without significant differences in the control period. Between the intervention assessments, they had statistically significant differences in MIP, MEP, FVC, Tiffeneau index, MVV, and fatigue. The study demonstrated that the aquatic physical exercise intervention was effective for ventilatory outcomes and fatigue in people with PD.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of an Aquatic Physical Exercise Program on Ventilatory Parameters in People with Parkinson’s Disease

Yamaguchi

Iucksch

Paladini

et al. 2022

Parkinson's Disease

View full text Add to dashboard Cite

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The Influence of Lung Function and Respiratory Muscle Strength on Quadriceps Muscle Fatigability in COPD Patients Under Long-term Oxygen Therapy

Paneroni,

Cavicchia,

Beatrice

et al. 2024

Archivos de Bronconeumología

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Altered locomotor muscle metaboreflex control of ventilation in patients with COPD

Aranda,

Ribeiro,

Freitas

et al. 2024

Journal of Applied Physiology

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We investigated the locomotor muscle metaboreflex control of ventilation, circulation, and dyspnea in patients with chronic obstructive pulmonary disease (COPD). Ten patients [FEV1 (mean ± SD) = 43 ± 17% predicted] and nine age- and sex-matched controls underwent: 1) cycling exercise followed by post-exercise circulatory occlusion (PECO) to activate the metaboreflex or free circulatory flow to inactivate it; 2) cold pressor test to interpret whether any altered reflex response was specific to the metaboreflex arc; and 3) muscle biopsy to explore the metaboreflex arc afferent side. We measured airflow, dyspnea, heart rate, arterial pressure, muscle blood flow, and vascular conductance during reflexes activation. Additionally, we measured fiber types, glutathione redox balance, and metaboreceptor-related mRNAs in the vastus lateralis. Metaboreflex activation increased ventilation versus free flow in patients (⁓15%, P < 0.020) but not in controls (P > 0.450). In contrast, metaboreflex activation did not change dyspnea in patients (P = 1.000) but increased it in controls (⁓100%, P < 0.001). Other metaboreflex-induced responses were similar between groups. Cold receptor activation increased ventilation similarly in both groups (P = 0.46). Patients had greater type II skeletal myocyte percentage (14%, P = 0.010), lower glutathione ratio (-34%, P = 0.015), and lower nerve growth factor (NGF) mRNA expression (-60%, P = 0.031) than controls. Therefore, COPD altered the locomotor muscle metaboreflex control of ventilation. It increased type II myocyte percentage and elicited redox imbalance, potentially producing more muscle metaboreceptor stimuli. Moreover, it decreased NGF expression, suggesting a downregulation of metabolically-sensitive muscle afferents.

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Abnormal muscle metaboreflex control of ventilation in patients with chronic obstructive pulmonary disease: what mechanisms should be blamed?

Cited by 3 publications

References 5 publications

Effects of an Aquatic Physical Exercise Program on Ventilatory Parameters in People with Parkinson’s Disease

Effects of an Aquatic Physical Exercise Program on Ventilatory Parameters in People with Parkinson’s Disease

The Influence of Lung Function and Respiratory Muscle Strength on Quadriceps Muscle Fatigability in COPD Patients Under Long-term Oxygen Therapy

Altered locomotor muscle metaboreflex control of ventilation in patients with COPD

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