Abnormal microcirculation in brain tumours during surgery

Mathura, Keshen R.; Bouma, Gerrit J.; İnce, Can

doi:10.1016/s0140-6736(01)06722-8

Cited by 72 publications

(34 citation statements)

References 3 publications

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“…To provide a sterile barrier between the brain surface and the device a sterilized plastic cap was placed over the tip of the probe followed by a plastic drape, covering the rest of the instrument as described elsewhere. 12 The probe was held stable in place on the cortical surface without pressure using an adapted Layla retractor arm.…”

Section: Orthogonal Polarization Spectral Imaging (Ops) Techniquementioning

confidence: 99%

“…We introduced orthogonal polarization spectral (OPS) imaging to the study of the human brain microcirculation, 11,12 and validated this technique by comparison of OPS imaging to the gold standard of nail fold capillaroscopy. 13 In the present study, we applied OPS imaging during aneurysm surgery to test the hypothesis that the presence of subarachnoid blood affects the contractile properties of the human cerebral microcirculation during the early course of SAH.…”

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confidence: 99%

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Direct Observation of the Human Cerebral Microcirculation During Aneurysm Surgery Reveals Increased Arteriolar Contractility

Pennings

Bouma

İnce

2004

Stroke

Self Cite

104

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Background and Purpose-The effects of aneurysmal subarachnoid hemorrhage on morphology and function of the cerebral microcirculation are poorly defined, partly due to the lack of suitable techniques to visualize the microvessels in vivo. We used orthogonal polarization spectral (OPS) imaging on the brain cortex during aneurysm surgery to directly observe the small cortical blood vessels and quantify their responses to hypocapnia. Methods-In 16 patients undergoing aneurysm surgery, the diameter changes of small cortical vessels (15 to 180 m) were observed using OPS imaging. Ten patients were operated on early (within 48 hours after bleeding) and 6 underwent late surgery. Immediately after dura opening, the response to hyperventilation of arterioles and venules was observed with OPS imaging under sevoflurane anesthesia. Results-In patients operated on early, layers of subarachnoid blood were clearly visible. In this group, hyperventilation resulted in a 39Ϯ15% decrease in arteriolar diameter with a "bead-string" constriction pattern occurring in 60% of patients. In late surgery and in controls, no subarachnoid blood was seen. The arteriolar diameter decrease with hyperventilation was 17Ϯ20% in patients undergoing late surgery and 7Ϯ7% in controls. Venules were not affected by hyperventilation in any of the groups studied. Conclusions-OPS imaging allows direct in vivo observation of the cerebral microcirculation enabling us, for the first time, to visually observe and quantify microvascular reactivity in the human brain. The present study demonstrates increased contractile responses of the cerebral arterioles in the presence of subarachnoid blood, suggesting increased microvascular tonus with possibly greater susceptibility to ischemia.

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Section: Orthogonal Polarization Spectral Imaging (Ops) Techniquementioning

confidence: 99%

mentioning

confidence: 99%

Direct Observation of the Human Cerebral Microcirculation During Aneurysm Surgery Reveals Increased Arteriolar Contractility

Pennings

Bouma

İnce

2004

Stroke

Self Cite

104

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“…So far, these devices were predominantly applied sublingually, to determine microvascular dysfunction in critically ill patients [14, 15]. They have also been used to assess oral mucosal wound healing and appraise the microcirculatory characteristics of different human organ surfaces such as the brain, skin, gut, intestines, conjunctiva, vagina, and liver [16-24]. This multitude of data emphasizes the importance of organ microcirculation and illustrates the broad applicability and potential advantages of these imaging modalities.…”

Section: Introductionmentioning

confidence: 99%

Intraoperative Incident Dark Field Imaging of the Human Peritoneal Microcirculation

Kastelein

Milstein

et al. 2018

J Vasc Res

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Background/Aims: This study describes the peritoneal microcirculation, compares quantitative parameters and angioarchitecture to the standard of sublingual microcirculatory assessment, and determines the practical feasibility of this method. Methods: Incident dark field imaging was performed of the peritoneum and sublingually to determine angioarchitecture, total and perfused vessel density (TVD and PVD), the proportion of perfused vessels (PPV), the microvascular flow index (MFI) and image acquisition time. Results: Peritoneal angioarchitecture was characterized by a quadrangular network of longitudinally oriented capillaries, often flanked by fat cells. Differences between peritoneal and sublingual microcirculation were observed with regard to TVD (peritoneum 12 mm/mm² [95% CI 10–14] vs. sublingual 23 mm/mm² [95% CI 21–25]; p < 0.0001), PVD (peritoneum 11 mm/mm² [95% CI 9–13] vs. sublingual 23 mm/mm² [95% CI 21–25]; p < 0.0001), PPV (peritoneum 88% [95% CI 79–97] vs. sublingual 99% [95% CI 99–100]; p = 0.014), and MFI (peritoneum 3 [IQR 2.3–3.0] vs. sublingual 3 [IQR 3.0–3.0]; p = 0.012). There was no difference in image acquisition time (peritoneum 2: 34 min [95% CI 1: 49–3: 19] vs. sublingual 2: 38 [95% CI 1: 37–3: 32]; p = 0.916). Conclusion: The peritoneal microcirculation was characterized by a low capillary density and a distinctive angioarchitecture. The possibility of peritoneal microcirculatory assessment offers promise for the study of peritoneal (patho-)physiology and (monitoring or detection of) associated diseases.

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“…OPS has recently been introduced in the clinical setting to image distinctive microvascular and hematological pathologies associated with different disease states, including (cardio)vascular diseases, cancer, and sepsis [2][3][4]. The imaging technique allows the observation of vascular structures and endovascular constituents (red blood cells and leukocytes) at high contrast [5], and facilitates quantitative measurements of physiological parameters (red blood cell velocity, vasomotion) as well as pathophysiological conditions (ischemia/reperfusion, hemorrhage, tumor angiogenesis) without requiring contrast enhancers or fluorescent dyes [3,[6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Darkfield orthogonal polarized spectral imaging for studying endovascular laser-tissue interactions in vivo-a preliminary study

et al. 2005

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Due to the limited number of suitable intravital microscopy techniques, relatively little is known about the opto-thermal (endo)vascular responses to selective photothermolysis, used as a default treatment modality for superficial vascular anomalies such as port wine stains, telangiectasias, and hemangiomas. In this preliminary study we present a novel microscopy technique for studying (endo)vascular laser-tissue interactions in vivo, in which conventional orthogonal polarized spectral (OPS) imaging is combined with darkfield (DF) illumination. DFOPS imaging of rat mesenteric vasculature irradiated at increasing powers revealed the following (tissular) responses: formation of translucent aggregates, retrograde flow, gradual and immediate hemostasis, reinstatement of flow, vessel disappearance, and perivascular collagen damage. DFOPS imaging therefore constitutes a useful tool for examining (endo)vascular events following selective photothermolysis. W. Groner, J. W. Winkelman, A. G. Harris, C. Ince, G. J. Bouma, K. Messmer, and R. G. Nadeau, "Orthogonal polarization spectral imaging: a new method for study of the microcirculation," Nat. Med. 5, 1209-1212 (1999

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Abnormal microcirculation in brain tumours during surgery

Cited by 72 publications

References 3 publications

Direct Observation of the Human Cerebral Microcirculation During Aneurysm Surgery Reveals Increased Arteriolar Contractility

Direct Observation of the Human Cerebral Microcirculation During Aneurysm Surgery Reveals Increased Arteriolar Contractility

Intraoperative Incident Dark Field Imaging of the Human Peritoneal Microcirculation

Darkfield orthogonal polarized spectral imaging for studying endovascular laser-tissue interactions in vivo-a preliminary study

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