Abnormal metabolite concentrations and amygdala volume in patients with recent-onset posttraumatic stress disorder

Su, Xiaorui; Xia, Chunchao; Wang, Weina; Sun, Huaiqiang; Tan, Qiaoyue; Zhang, Simin; Li, Lingjiang; Kemp, Graham J.; Yue, Qiang; Gong, Qiyong

doi:10.1016/j.jad.2018.08.018

Cited by 12 publications

(14 citation statements)

References 70 publications

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“…These findings further support the conclusions of a previous systematic review observing consistent decreases in hippocampal and anterior cingulate cortex NAA across the 1 H-MRS literature on PTSD. 46 In particular, our anterior cingulate cortex results also extend previous meta-analytic findings of decreased anterior cingulate NAA/Cr in PTSD relative to healthy controls and update three previously reviewed comparisons from two studies 71 , 75 underlying a significant effect of NAA in anterior cingulate cortex 45 with four more 63 , 69 , 74 , 77 that bring this metabolite result to non-significance. Similarly, reported reductions in left hippocampal NAA/Cr and NAA extend previously significant meta-analytic findings in both indices.…”

Section: Discussionsupporting

confidence: 84%

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Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

et al. 2022

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A stressor-related disorder wherein traumatic experience precipitates protracted disruptions to mood and cognition, post-traumatic stress disorder (PTSD) is associated with wide-ranging abnormalities across the body. While various methods have investigated these deviations, only proton magnetic resonance spectroscopy (1H MRS) enables noninvasive measurement of small-molecule metabolites in the living human. 1H MRS has correspondingly been employed to test hypotheses about the composition and function of multiple brain regions putatively involved in PTSD. Here we systematically review methodological considerations and reported findings, both positive and negative, of the current 1H-MRS literature in PTSD (N = 32 studies) to communicate the brain regional metabolite alterations heretofore observed, providing random-effects model meta-analyses for those most extensively studied. Our review suggests significant PTSD-associated decreases in N-acetyl aspartate in bilateral hippocampus and anterior cingulate cortex with less evident effect in other metabolites and regions. Model heterogeneities diverged widely by analysis (I2 < 0.01% to 90.1%) and suggested regional dependence on quantification reference (creatine or otherwise). While observed variabilities in methods and reported findings suggest that 1H-MRS explorations of PTSD could benefit from methodological standardization, informing this standardization by quantitative assessment of the existing literature is currently hampered by its small size and limited scope.

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Section: Discussionsupporting

confidence: 84%

“…Complementarily to numerous non- 1 H-MRS findings in PTSD, comparative and/or correlation analyses of amygdalar NAA, 74 , 86 creatine, 59 , 74 , 86 choline, 74 , 86 myoinositol, 74 , 86 and Glx 74 have been reported ( Figures 4 and 5 ; Tables 6 and 7 ; Supplementary Information ).…”

Section: Resultsmentioning

confidence: 99%

Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

et al. 2022

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“…However, due to genetic differences, reconciling findings between rats and mice [91], let alone rodents and humans [92], is not straightforward and thus complicates the picture. In the only human study we are aware of, patients with PTSD exhibited an elevated Cr and mI concentration in the left and right amygdala, respectively [57]. These rather limited data do not reconcile with the current findings.…”

Section: Discussioncontrasting

confidence: 77%

“…Moreover, as alluded to above, because trans persons experience gender dysphoria/incongruence and minority stress [46][47][48][49] as well as anxiety and depression [50][51][52], another brain region that may be of interest is the amygdala, given its involvement in anxiety [53,54], depression [55], and stress-related disorders [56]. In this region, one study in participants exposed to stress indicated elevated creatine levels as well as increased levels of NAA and mI [57].…”

Section: Introductionmentioning

confidence: 99%

Characterization of the 1H-MRS Metabolite Spectra in Transgender Men with Gender Dysphoria and Cisgender People

Collet

Bhaduri

Kiyar

et al. 2021

JCM

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Much research has been conducted on sexual differences of the human brain to determine whether and to what extent a brain gender exists. Consequently, a variety of studies using different neuroimaging techniques attempted to identify the existence of a brain phenotype in people with gender dysphoria (GD). However, to date, brain sexual differences at the metabolite level using magnetic resonance spectroscopy (1H-MRS) have not been explored in transgender people. In this study, 28 cisgender men (CM) and 34 cisgender women (CW) and 29 transgender men with GD (TMGD) underwent 1H-MRS at 3 Tesla MRI to characterize common brain metabolites. Specifically, levels of N–acetyl aspartate (NAA), choline (Cho), creatine (Cr), glutamate and glutamine (Glx), and myo-inositol + glycine (mI + Gly) were assessed in two brain regions, the amygdala-anterior hippocampus and the lateral parietal cortex. The results indicated a sex-assigned at birth pattern for Cho/Cr in the amygdala of TMGD. In the parietal cortex, a sex-assigned at birth and an intermediate pattern were found. Though assessed post-hoc, exploration of the age of onset of GD in TMGD demonstrated within-group differences in absolute NAA and relative Cho/Cr levels, suggestive for a possible developmental trend. While brain metabolite levels in TMGD resembled those of CW, some interesting findings, such as modulation of metabolite concentrations by age of onset of GD, warrant future inquiry.

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“…A recent study not discussed in the review analyzed the metabolic variations in the amygdala and anterior cingulate cortex (ACC) of PTSD subjects (n = 78) and age/sex matched controls (n = 71) using 1 H-NMR and magnetic resonance imaging [212]. Significantly increased concentrations of NAA in the ACC and increased concentrations of Cr and myo-inositol (MI) were identified in the amygdala.…”

Section: Post-traumatic Stress Disorder (Ptsd)mentioning

confidence: 99%

Metabolomics in Central Sensitivity Syndromes

Miller

Rodríguez-Saona

Hackshaw³

2020

Metabolites

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Central sensitization syndromes are a collection of frequently painful disorders that contribute to decreased quality of life and increased risk of opiate abuse. Although these disorders cause significant morbidity, they frequently lack reliable diagnostic tests. As such, technologies that can identify key moieties in central sensitization disorders may contribute to the identification of novel therapeutic targets and more precise treatment options. The analysis of small molecules in biological samples through metabolomics has improved greatly and may be the technology needed to identify key moieties in difficult to diagnose diseases. In this review, we discuss the current state of metabolomics as it relates to central sensitization disorders. From initial literature review until Feb 2020, PubMed, Embase, and Scopus were searched for applicable studies. We included cohort studies, case series, and interventional studies of both adults and children affected by central sensitivity syndromes. The majority of metabolomic studies addressing a CSS found significantly altered metabolites that allowed for differentiation of CSS patients from healthy controls. Therefore, the published literature overwhelmingly supports the use of metabolomics in CSS. Further research into these altered metabolites and their respective metabolic pathways may provide more reliable and effective therapeutics for these syndromes.

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Abnormal metabolite concentrations and amygdala volume in patients with recent-onset posttraumatic stress disorder

Cited by 12 publications

References 70 publications

Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

Proton Magnetic Resonance Spectroscopy in Post-Traumatic Stress Disorder—Updated Systematic Review and Meta-Analysis

Characterization of the 1H-MRS Metabolite Spectra in Transgender Men with Gender Dysphoria and Cisgender People

Metabolomics in Central Sensitivity Syndromes

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