Abnormal lung function at preschool age asthma in adolescence?

Lajunen, Katariina; Kalliola, Satu; Kotaniemi‐Syrjänen, Anne; Sarna, Seppo; Malmberg, L. Pekka; Pelkonen, Anna; Mäkelä, Mika J.

doi:10.1016/j.anai.2018.03.002

Cited by 19 publications

(38 citation statements)

References 34 publications

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“…Instead, IOS alone showed good potential as a screening method for persistent asthma with connection to both objective and subjective signs. These prognostic features of baseline R5 and X5 (both representatives of small airways) were further elucidated when compared to our previous study, when these features were evaluated with a control group 11 . However, the predictive value of IOS parameters and hypertonic saline are more indicative than conclusive and further studies are necessary.…”

Section: Discussionmentioning

confidence: 80%

“…IOS was combined with an outdoor exercise challenge test and a bronchodilator test. The entry criteria included either increase of ≥ 35% in resistance at 5 Hz (R5) after exercise challenge or a decrease of ≥ 35% in R5 after bronchodilation test 11 . At this age, AHR was also estimated with a bronchial challenge test with hypertonic saline.…”

Section: Methodsmentioning

confidence: 99%

“…With regard to early wheezing, the connection appears to be controversial 6,10 . Although lung function measured with impulse oscillometry (IOS) in preschool children is a versatile prognostic tool, the association with later AHR remains unclear 11 …”

Section: Introductionmentioning

confidence: 99%

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Predictive value of childhood airway hyper‐responsiveness to indirect stimuli: 10‐year longitudinal study

Lajunen

Malmberg

Kalliola

et al. 2020

Pediatric Allergy Immunology

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Section: Discussionmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

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Predictive value of childhood airway hyper‐responsiveness to indirect stimuli: 10‐year longitudinal study

Lajunen

Malmberg

Kalliola

et al. 2020

Pediatric Allergy Immunology

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“…However, positive API preschoolers with ICS had significantly higher central basal airway resistance (RA at 20 Hz) and higher post-BD response (% change in FEF 25−75 and FEV 0.5 ) than those positive API without ICS; suggesting that preschoolers with positive API and ICS use may have some airway dysfunction (49). Recently, a Finish longitudinal study (50) about lung function assessed with IOS measured at preschool age ( n = 255) and at adolescence, showed that abnormal baseline values (poor R5) during preschool were significantly associated with: low lung function, need for asthma medication, and asthma symptoms during adolescence. And a positive API at preschool age was associated with asthma symptoms (OR: 13.7 [1.4–147.1]) and need for asthma medication (OR: 14.6 [1.4–147.1]), but not with abnormal lung function at adolescence (50).…”

Section: Predictive Models For Prognostic or Diagnostic Toolsmentioning

confidence: 99%

Predicting Asthma Using Clinical Indexes

2019

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Asthma is no longer considered a single disease, but a common label for a set of heterogeneous conditions with shared clinical symptoms but associated with different cellular and molecular mechanisms. Several wheezing phenotypes coexist at preschool age but not all preschoolers with recurrent wheezing develop asthma at school-age; and since at the present no accurate single screening test using genetic or biochemical markers has been developed to determine which preschooler with recurrent wheezing will have asthma at school age, the asthma diagnosis still needs to be based on clinical predicted models or scores. The purpose of this review is to summarize the existing and most frequently used asthma predicting models, to discuss their advantages/disadvantages, and their accomplishment on all the necessary consecutive steps for any predictive model. Seven most popular asthma predictive models were reviewed (original API, Isle of Wight, PIAMA, modified API, ucAPI, APT Leicestersher, and ademAPI). Among these, the original API has a good positive LR~7.4 (increases the probability of a prediction of asthma by 2–7 times), and it is also simple: it only requires four clinical parameters and a peripheral blood sample for eosinophil count. It is thus an easy model to use in any rural or urban health care system. However, because its negative LR is not good, it cannot be used to rule out the development of asthma.

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“…Studies in children are very limited in this regard. One study has noted that in children between the ages of 3 and 8 years old, a change in the R5/R20 after methacholine challenge was significantly higher in those children with more severe asthma as shown by increased exercise-induced bronchospasm and short-acting beta 2 agonist use [11].…”

Section: Ios and Airway Hyperreactivitymentioning

confidence: 99%

Clinical Applications of Impulse Oscillometry

Saadeh¹,

Davey-Ranasinghe²

2019

Asthma - Biological Evidences

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Impulse oscillometry is a noninvasive procedure that can be performed within few minutes. The purpose of the procedure is to measure the resistance of the small and large airways, as well as the reactants of the airways. It is gradually gaining popularity in evaluating lung function, particularly in patients with asthma and COPD. In contrast to spirometry, the test performs measurement during tidal breathing. In other words, forced exhalation is not required. Other advantages include, but are not limited to, evaluating COPD patients' reversibility which is rarely noted on spirometry. IOS also is tool for chronic management of patients with asthma and COPD while on treatment. It can evaluate children with asthma even as young as 2 years old. Spirometry requires the child to cooperate and usually is of meaningful use beginning at the age of 5 years old. Other potential applications include early evaluation of transplant rejection, cystic fibrosis, and vocal cord disorder. In this chapter, we will explore the procedure itself, the settings, advantages and disadvantages, and comparative data with spirometry.

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Abnormal lung function at preschool age asthma in adolescence?

Abstract: Abnormal preschool IOS is associated with asthma and poor lung function in adolescence and might be utilised for identification of asthma persistence.

Cited by 19 publications

References 34 publications

Predictive value of childhood airway hyper‐responsiveness to indirect stimuli: 10‐year longitudinal study

Predictive value of childhood airway hyper‐responsiveness to indirect stimuli: 10‐year longitudinal study

Predicting Asthma Using Clinical Indexes

Clinical Applications of Impulse Oscillometry

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