Abnormal localization of iron regulatory protein in Alzheimer's disease

Smith, Mark A.; Wehr, Kristina; Harris, Peggy L.R.; Siedlak, Sandra L.; Connor, James R.; Perry, George

doi:10.1016/s0006-8993(98)00002-x

Cited by 160 publications

(97 citation statements)

References 33 publications

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“…A study of brain tissue from control and AD-afflicted subjects demonstrated that IRP1 expression was similar in both groups, whereas IRP2 expression was altered in AD. In AD, IRP2 was localized in regions with redox active iron and was associated with such pathologic features as neurofibrillary tangles and senile plaques (280). An IRE was recently identified at ϩ51 to ϩ94 from the 5Ј cap in the 5Ј-UTR of Alzheimer amyloid precursor protein (260), a critical mediator of the formation of plaques involved in the pathogenesis of AD.…”

Section: Iron Regulation and Neurodegenerationmentioning

confidence: 99%

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

Mackenzie

Iwasaki

Tsuji

2008

Antioxidants & Redox Signaling

444

372

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Section: Iron Regulation and Neurodegenerationmentioning

confidence: 99%

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

Mackenzie

Iwasaki

Tsuji

2008

Antioxidants & Redox Signaling

444

372

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“…Specifically, alteration in IRP-2 might be directly linked to impaired iron homeostasis leading to neurofibrillary tangles, senile plaques and neuropil threads in Alzheimer's patients [2].…”

Section: Introductionmentioning

confidence: 99%

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

et al. 2012

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This study aimed to elucidate the mechanisms of melatonin to manage neurological damage in Alzheimer's disease (AD) induced in ovariectomized rats. Forty adult female rats were enrolled in our study and were classified as; gonad intact control, ovariectomized control group, ovariectomized rats received melatonin, ovariectomized rats injected with AlCl 3 to induce AD and ADinduced rats treated with melatonin. Hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), B cell lymphoma 2 (Bcl-2), brain derived neurotrophic factor (BDNF), acetylcholinesterase (AchE) and acetylcholine (Ach) were estimated in the brain tissues of the different groups. Treatment of AD-induced rats with melatonin produced marked improvement in the most studied biomarkers which was confirmed by histological investigation of the brain. In Conclusion, melatonin significantly ameliorates the neurodegeneration characteristic of AD in experimental animal model due to its antioxidant, antiapoptotic, neurotrophic and anti-amyloidogenic activities.

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“…IRP-1, but not IRP-2, is rapidly activated by extracellular H 2 O 2 , establishing a regulatory connection between the control of iron metabolism and response to oxidative stress. Whereas IRP-1 was found to be present in similar levels in both AD and control brain tissue, IRP-2 co-localized with redox-active iron in neurofibrillary tangles (NFT), SP neurites, and neuropil threads [102]. These results suggest that alterations in IRP-2 may be directly linked to impaired iron homeostasis in AD.…”

Section: Iron In Neurodegenerationmentioning

confidence: 83%

Mechanisms by which metals promote events connected to neurodegenerative diseases

Campbell

Smith

Sayre

et al. 2001

Brain Research Bulletin

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Although the exact causative phenomenon responsible for the onset and progression of neurodegenerative disorders is at present unresolved, there are some clues as to the mechanisms underlying these chronic diseases. This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration.

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Abnormal localization of iron regulatory protein in Alzheimer's disease

Cited by 160 publications

References 33 publications

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

Intracellular Iron Transport and Storage: From Molecular Mechanisms to Health Implications

Does Melatonin Ameliorate Neurological Changes Associated With Alzheimer’s Disease in Ovariectomized Rat Model?

Mechanisms by which metals promote events connected to neurodegenerative diseases

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