Abnormal Lipoprotein and Apolipoprotein Pattern in Lipoprotein Glomerulopathy

Oikawa, Shinichi; Suzuki, Norihiro; Sakuma, Eriko; Saito, Takao; Namai, Kazuyuki; Kotake, Hidetoshi; Fujii, Yutaka; Toyota, Takayoshi

doi:10.1016/s0272-6386(12)80649-4

Cited by 59 publications

(42 citation statements)

References 27 publications

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“…The detection of Apo B and E in capillary luminal deposits implied the possible attribution of an altered solubility of very low density lipoproteins (VLDLs) and/or VLDL remnants in the local environment causing the formation of ‘lipoprotein plugs’. There is clearly a racial predominance in oriental people, as 13 Japanese and 1 Chinese [1, 2, 3, 4, 5, 6, 7, 9] but only 2 Caucasian cases have been reported [8, 10]. In this report, we describe 2 cases of lipoprotein glomerulopathy with a new Apo E genotype (E3/E4).…”

Section: Introductionmentioning

confidence: 78%

“…Since the glomerular disease with deposition of lipoprotein ‘thrombi’ in glomeruli was first described in a review of renal lipidoses by Faraggiana et al [1] in 1987, 16 cases of this unique glomerular disease have been reported [2, 3, 4, 5, 6, 7, 8, 9, 10]. The disease is characterized by aneurysmal dilatation of glomerular capillaries with intraluminal deposition of insoluble material containing lipoproteins and lipid.…”

Section: Introductionmentioning

confidence: 99%

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Association of Apolipoprotein E Polymorphism with Lipoprotein Glomerulopathy

Yang

Ng²,

Tarng³

et al. 1998

Nephron

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Two cases of lipoprotein glomerulopathy with a new apolipoprotein E (Apo E) genotype, Ε3/Ε4, were diagnosed recently. These 2 cases, together with other cases documented in English literature made a total of 6 common isoforms of Apo E encountered in lipoprotein glomerulopathy. Although the calculated allele frequency of Ε2 is relative high in cases with lipoprotein glomerulopathy as compared with that in the general population (39.3 vs. 6.4–11.4%), the gradual emergence of Apo E isoforms other than E2/E3 in lipoprotein glomerulopathy implicates that the genetic susceptibility of certain Apo E isoforms may not be a crucial factor. An alteration in the local environment of glomerular capillaries may be more important in the pathogenesis of lipoprotein glomerulopathy.

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Section: Introductionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Association of Apolipoprotein E Polymorphism with Lipoprotein Glomerulopathy

Yang

Ng²,

Tarng³

et al. 1998

Nephron

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“…A recent report suggested that early diagno- . As discussed, LPG is a genetic kidney disease, but with a lipoprotein profile 17) similar to that of chronic kidney disease (CKD), and shows increases of serum triglycerides, VLDL and IDL 18) ; therefore, LPG analysis might be important for identifying the relationship between dyslipidemia and various other kidney diseases. We expect that additional cases of LPG will contribute to revealing the pathophysiology of the relationship between CKD and lipoproteins as well as of LPG itself.…”

Section: Discussionmentioning

confidence: 99%

A Novel Mutation ApoE2 Kurashiki (R158P) in a Patient with Lipoprotein Glomerulopathy

Tokura

Itano

Kobayashi

et al. 2011

JAT

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Lipoprotein glomerulopathy (LPG) is a rare glomerulopathy caused by lipoprotein thrombi. In almost all cases of LPG, several apolipoprotein (apo) E mutations were reported. Here, we present a case of LPG caused by a novel mutation that we named ApoE2 Kurashiki, which substitutes arginine with proline at apoE codon 158. ApoE2 polymorphism is well known for its relationship to type hyperlipoproteinemia, and the common apoE2 isoform is encoded by the R158C allele. ApoE2 Kurashiki substitutes at the same codon and cannot be distinguished from common apoE2 by standard apoE genotyping or phenotyping.J Atheroscler Thromb, 2011; 18:536-541.

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“…Type hyperlipoproteinemia with a high apolipoprotein E (apoE) level in serum is a distinctive feature in the lipoprotein profile 2) . Approximately 100 cases of LPG have been reported in the world since we published the first case in the American Journal of Kidney Diseases in 1989 3) , and the characteristics mentioned above are common to almost all LPG cases.…”

Section: Significance Of a Novel Apolipoprotein E Variant Apoe Osakamentioning

confidence: 99%