Abnormal lipid metabolism in metabolic syndrome: an epigenetic perspective

Brudașcă, Ioana; Cucuianu, M

doi:10.1515/rrlm-2016-0025

Cited by 4 publications

(4 citation statements)

References 40 publications

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“…Recent scientific data support the influence of lifestyle-related factors, such as unhealthy diet and lack of exercise, on the development of metabolic syndrome by causing epigenetic changes, influencing gene expression, having hyperglycemia, hypertriglyceridemia and low values of HDL-cholesterol as a consequence (26).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation

Nemes-Nagy

Fogarasi

Croitoru

et al. 2022

Revista Romana De Medicina De Laborator

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Introduction: Hypertension and diabetes mellitus affect a large number of patients and can significantly influence their life expectancy. Changes in metabolic and oxidative stress parameters are common in these pathologies, contributing to associated complications. The aim of the study was assessment of relationship between laboratory parameters and their role in evaluation of cardiovascular risk, and possible gender-related differences in the protective factors. Material and methods: Blood samples were collected from hypertensive patients with/without diabetes mellitus admitted to the Cardiovascular Rehabilitation Clinic in Tîrgu Mureș and controls without these pathologies. Biochemical analyses were performed on Konelab analyzer (glycemia, lipid profile, kidney function tests, zinc, hsCRP). Oxidative stress markers, such as serum malondialdehyde (MDA), oxidized (GSSG) and reduced glutathione (GSH) were evaluated using an HPLC-UV/VIS technique at GEP UMPhST. Statistical analysis was performed by GraphPad InStat3. Results: Mean age of hypertensive patients (n=131) was 69.44 ± 9.02 years, 45.8% males, 31.3% being diabetics. 74.1% of the studied patients had zinc deficiency, 19.8% presented slightly elevated hsCRP. The control group included 24 nonhypertensive/nondiabetic patients of similar age. Average GSH was significantly lower (p=0.0002) in hypertensive patients, 1.89 ± 0.82 µg/ml, compared to the control group (3.23 ± 0.49 µg/ml), and no correlation could be observed between GSH and MDA values. GSH concentration was significantly higher in males (p=0.0395) and HDL-cholesterol significantly higher in females (p=0.0132). A negative correlation was observed between serum triglyceride and HDL-cholesterol concentration. Conclusions: Gender differences are present in the level of protective factors against cardiovascular diseases, while oxidative stress is intensified in hypertensive/diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation

Nemes-Nagy

Fogarasi

Croitoru

et al. 2022

Revista Romana De Medicina De Laborator

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“…Consistent with the DOHaD hypothesis, strong links exist between both maternal and early-life nutrition and cardiovascular disease [ 21 ], diabetes and obesity [ 22 ] along with asthma and allergy, autoimmune disease, cancer and mental health [ 23–26 ]. Inappropriate maternal nutrition in rodents has been linked to incorrect epigenetic ‘priming’ during foetal or post-natal life [ 27 , 28 ]; in particular, experiments conducted in Drosophila show that diets high in carbohydrate content (sugar) have been shown to programme metabolic status and diabetes [ 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

A ‘phenotypic hangover’: the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome of Drosophila melanogaster

Osborne

Dearden

2017

Environmental Epigenetics

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The Developmental Origins of Health and Disease hypothesis predicts that early-life environmental exposures can be detrimental to later-life health and that mismatch between the pre- and post-natal environment may contribute to the growing non-communicable disease epidemic. Within this is an increasingly recognized role for epigenetic mechanisms; for example, epigenetic modifications can be influenced by nutrition and can alter gene expression in mothers and offspring. Currently, there are few whole-genome transcriptional studies of response to nutritional alteration. Thus, we sought to explore how nutrition affects the expression of genes involved in epigenetic processes in Drosophila melanogaster. We manipulated Drosophila food macronutrient composition at the F0 generation, mismatched F1 offspring back to a standard diet and analysed the transcriptome of the F0–F3 generations by RNA sequencing. At F0, the altered (high-protein, low-carbohydrate) diet increased expression of genes classified as having roles in epigenetic processes, with co-ordinated down-regulation of genes involved in immunity, neurotransmission and neurodevelopment, oxidative stress and metabolism. Upon reversion to standard nutrition, mismatched F1 and F2 generations displayed multigenerational inheritance of altered gene expression. By the F3 generation, gene expression had reverted to F0 (matched) levels. These nutritionally induced gene expression changes demonstrate that dietary alterations can up-regulate epigenetic genes, which may influence the expression of genes with broad biological functions. Furthermore, the multigenerational inheritance of the gene expression changes in F1 and F2 mismatched generations suggests a predictive adaptive response to maternal nutrition, aiding the understanding of the interaction between maternal diet and offspring health, with direct implications for the current non-communicable disease epidemic.

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“…Consistent with the DOHaD hypothesis, strong links exist between both maternal and early life nutrition and cardiovascular disease (Barker, 1997), diabetes and obesity (Uauy et al, 2011) along with asthma and allergy, autoimmune disease, cancer and mental health (Gluckman et al, 2011, Barouki et al, 2012, Hanson and Gluckman, 2015, Balbus et al, 2013). Inappropriate maternal nutrition has been linked to incorrect epigenetic ‘priming’ during fetal or postnatal life (Burdge et al, 2007b, Brudasca and Cucuianu, 2016); in particular, diets high in carbohydrate content (sugar) have been shown to program metabolic status and diabetes (Buescher et al, 2013, Musselman et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

A ‘phenotypic hangover’ – the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome ofDrosophila melanogaster

Osborne

Dearden

2017

Preprint

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The Developmental Origins of Health and Disease (DOHaD) hypothesis predicts that early-life environmental exposures can be detrimental to later-life health, and that mismatch between the pre- and postnatal environment may contribute to the growing non-communicable disease (NCD) epidemic. Within this is an increasingly recognised role for epigenetic mechanisms; epigenetic modifications can be influenced by, e.g., nutrition, and can alter gene expression in mothers and offspring. Currently, there are no whole-genome transcriptional studies of response to nutritional alteration. Thus, we sought to explore how nutrition affects the expression of genes involved in epigenetic processes in Drosophila melanogaster. We manipulated Drosophila food macronutrient composition at the F0 generation, mismatched F1 offspring back to a standard diet, and analysed the transcriptome of the F0 – F3 generations by RNA-sequencing. At F0, the altered (high protein, low carbohydrate, HPLC) diet increased expression of genes involved in epigenetic processes, with coordinated downregulation of genes involved in immunity, neurotransmission and neurodevelopment, oxidative stress and metabolism. Upon reversion to standard nutrition, mismatched F1 and F2 generations displayed multigenerational inheritance of altered gene expression. By the F3 generation, gene expression had reverted to F0 (matched) levels. These nutritionally-induced gene expression changes demonstrate that dietary alteration can upregulate epigenetic genes, which may influence the expression of genes with broad biological functions. Further, the multigenerational inheritance of the gene expression changes in F1 and F2 mismatched generations suggests a predictive adaptive response (PAR) to maternal nutrition. Our findings may help to understand the interaction between maternal diet and future offspring health, and have direct implications for the current NCD epidemic.

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Abnormal lipid metabolism in metabolic syndrome: an epigenetic perspective

Abstract: Abstract

Cited by 4 publications

References 40 publications

Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation

Oxidative stress and metabolic parameters in hypertensive patients with/without diabetes mellitus in cardiovascular risk evaluation

A ‘phenotypic hangover’: the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome of Drosophila melanogaster

A ‘phenotypic hangover’ – the predictive adaptive response and multigenerational effects of altered nutrition on the transcriptome ofDrosophila melanogaster

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