Abnormal labour

Kither, Hannah; Samangaya, Rebekah A.

doi:10.1016/j.ogrm.2013.02.008

Cited by 1 publication

(2 citation statements)

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“…To overcome such conditions, Caesarean section (CS), forceps delivery (FD), oxytocin (OXT) [ 3 ], amniotomy [ 4 ], and hydration administration are used before delivery. OXT is a nonapeptide [ 5 ] that is naturally secreted by the posterior pituitary gland, and a synthetic form is used in AL for normal vaginal delivery [ 6 ]; it stimulates uterine contractility [ 3 ] and is also used in the treatment of postpartum hemorrhage [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, cardiac effects have been also reported by continuous infusion of OXT [ 6 ]. There are various regimens available for OXT, including low-dose [ 5 ], high-dose [ 3 ], increased frequency [ 5 ], and pulsatile preparations [ 9 ]. Different regimens have different outcome measures and adverse effects as per the conditions and profile of the patients [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Increased Frequency, High Dose, and Pulsatile Oxytocin Regimens on Abnormal Labor Delivery

Liu

Yang

2018

Med Sci Monit

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BackgroundThe current guideline for oxytocin regimens in the abnormal labor of delivery is continuous infusion. The objective of the present study was to compare effects and safety measures of various available regimens of oxytocin in abnormal labor delivery.Material/MethodsIn this clinical experimental study, a total of 900 pregnant women admitted for delivery were randomized into 5 group with 162 each. Pregnant women received oxytocin as continuous administration of 16 mU/min (Group I), 1 mU/min (group II), 4 mU/min (group III), 5 mU/min quarter-hourly (group IV), and through a syringe pump (group V). Measurement of the expense of delivery, the ratio of the instrumental delivery, and the other secondary outcome measures was performed to find the best regimen of oxytocin. The 2-tailed paired t test and Mann-Whitney U test following Dunnett’s multiple comparison tests were used at 95% confidence level.ResultsPulsatile delivery had least risk of instrumental delivery as compared to continuous infusion (p<0.0001, q=6.663) and normal-frequency low-dose (p<0.0001, q=5.638) of oxytocin. The time required from infusion to delivery was longer for group II (p=0.001, q=2.925), group IV (p<0.0001, q=4.829), and group V (p<0.0001, q=41.456) than for group I. The expense of delivery was: group I < group II < group IV < group III < group V.ConclusionsHigh-dose and pulsatile preparation of oxytocin had reduced risks of operative delivery vs. continuous administration.

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