Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders

Abstract

Impulse control disorders (ICD) in Parkinson’s disease (PD) might be attributed to misestimate of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the lateralization of monoamine network. Our objective was to probe the significant role of lateralization in the pathogenesis of ICD. Twenty-one PD patients with ICD (PD-ICD), thirty-three without ICD (PD-no ICD), and thirty-seven healthy controls (HCs) were recruited and performed T1-weighted, diffusion tensor imaging (DTI) scans and resting state functional magnetic resonance imaging (rs-fMRI). By applying the Voxel-mirrored Homotopic Connectivity (VMHC) and Freesurfer, we evaluated participants’ synchronicity of functional connectivity and structural changes between hemispheres. Also, tract-based spatial statistics (TBSS) was applied to compare fiber tracts differences. Relative to PD-no ICD group, PD-ICD group demonstrated reduced VMHC values in middle frontal gyrus (MFG). Compared to HCs, PD-ICD group mainly showed decreased VMHC values in MFG, middle and superior orbital frontal gyrus (OFG), inferior frontal gyrus (IFG) and caudate, which were related to reward processing and inhibitory control. The severity of impulsivity was negatively correlated with the mean VMHC values of MFG in PD-ICD group. Receiver operating characteristic (ROC) curves analyses uncovered that the mean VMHC values of MFG might be a potential marker identifying PD-ICD patients. However, we found no corresponding asymmetrical alteration in cortical thickness and no significant differences in fractional anisotropy (FA) and mean diffusivity (MD). Our results provided further evidence for asymmetry of functional connectivity in mesolimbic reward and response inhibition network in ICD.

Decreased resting-state neural signal in the left angular gyrus as a potential neuroimaging biomarker of schizophrenia: An amplitude of low-frequency fluctuation and support vector machine analysis

“…Resting-state functional magnetic resonance imaging (rs-fMRI) has emerged as a powerful tool that offers a potential means of identifying novel, sensitive biomarker signatures associated with specific brain disorders (3)(4)(5)(6). A growing body of evidence suggests that abnormal changes in patients with SCH are primarily found in the striatum (7), temporal lobe (8), default-mode network (DMN) (9), and frontoparietal network (10), although the specific nature of these changes has varied across studies, with some reporting functional signal increases (11-13), decreases (14), or both (15).…”

Exploring brain changes of impulse control disorders in Parkinson's disease: An ALE study

“…Figure 1 illustrated the initial search results and selection process. The study included 20 studies (Cilia et al, 2008 ; Frosini et al, 2010 ; Rao et al, 2010 ; van Eimeren et al, 2010 ; Voon et al, 2011 ; Ray et al, 2012 ; Cerasa et al, 2014 ; Lee et al, 2014 ; Biundo et al, 2015 ; Yoo et al, 2015 ; Premi et al, 2016 ; Tessitore et al, 2016 , 2017a , b ; Markovic et al, 2017 ; Filip et al, 2018 ; Imperiale et al, 2018 ; Verger et al, 2018 ; Esteban-Peñalba et al, 2021 ; Gan et al, 2021 ) (including 341 PD-ICD and 437 PD-no ICD).…”

“…N = 1 study (Rao et al, 2010 ) (including 9 PD-ICD and 9 PD-no ICD patients) showed significantly reduced regional cerebral blood flow (rCBF) in the right ventral striatum in PD-ICD, compared to PD-no ICD patients. N = 4 studies (Tessitore et al, 2017a , b ; Imperiale et al, 2018 ; Gan et al, 2021 ) (including 86 PD-ICD and 113 PD-no ICD patients) compared resting-state brain activation between PD-ICD and PD-no ICD patients. The ALE study showed reduced resting-state brain activation in the right IFG, the right PCG, the left insula and the right transverse temporal gyrus (TTG) in PD-ICD, compared to PD-no ICD patients ( Figure 3A and Supplementary table S2 ).…”

Altered Interhemispheric Functional Connectivity Associated With Early Verbal Fluency Decline After Deep Brain Stimulation in Parkinson’s Disease

“…Strong and weak homotopic RSFC were interpreted as a tendency to coordinate processing or independent processing in allelic brain regions, respectively (Baldo et al, 2001). In the past, many functional imaging studies have discovered impaired interhemispheric coordination among PD patients (Hu et al, 2015;Zhu et al, 2016;Li et al, 2018;Gan et al, 2021). The focus of this study was to explore changes in functional coordination of homotopic brain regions post-DBS.…”