Abnormal Hematologic Findings in Triploidy

Pd, Sadowitz; Balcolm, R; Gordon, Lauren

doi:10.1177/000992288402301107

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…These findings indicate that in triploidy erythrocytes share in the excessive cell size, abnormal cell growth and overall delay in maturation known to occur in this condition [16][17][18], In the clinical management of pregnancies complicated by the early onset fetal growth retardation, triploidy should be suspected if there is extreme asymmetry in the fetal growth pattern with relative sparing of head size and if the degree of reduction in amniotic fluid volume is inappropriately small for the severity of growth retardation. Mea surement of fetal MCV, which takes only a few minutes to perform, may be a useful adjunct in the evaluation of such fetuses.…”

Section: Commentmentioning

confidence: 99%

Mean Red Cell Volume in Normal, Anemic, Small, Trisomic and Triploid Fetuses

Nicolaides

Snijders²,

Thorpe-Beeston³

et al. 1989

Fetal Diagn Ther

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A reference range for fetal mean red cell volume (MCV) with gestation was established from the study of samples obtained by cordocentesis from 466 pregnancies undergoing prenatal diagnosis for non-erythrocyte abnormalities. The mean MCV decreased from 145 fl at 16 weeks to 113 fl at 36 weeks of gestation. Alterations in MCV were investigated in 154 red cell isoimmunized and 231 small for gestational age (SGA) fetuses. In red cell isoimmunization, significant macrocytosis was observed when the fetal hemoglobin concentration deficit was ≥6 g/dl. In the chromosomally normal SGA fetuses (n = 178), the MCV was increased and the magnitude of macrocytosis was significantly associated with gestation and the degrees of fetal ‘smallness’ and fetal hypoxemia. However, the most severely macrocytotic SGA fetuses were those with triploidy (n = 22). In the SGA fetuses with other chromosomal defects (n = 31), the MCV was higher than the controls but lower than that of the chromosomally normal hypoxemic fetuses. It is suggested that in severe growth retardation there is developmental delay in the normal evolution from hepatic to medullary hemopoiesis and this is most marked in triploid fetuses. In contrast, in red cell isoimmunization the switch to medullary erythropoiesis is normal, but in severe anemia there is secondary recruitment of hepatic erythropoiesis.

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Section: Commentmentioning

confidence: 99%

Mean Red Cell Volume in Normal, Anemic, Small, Trisomic and Triploid Fetuses

Nicolaides

Snijders²,

Thorpe-Beeston³

et al. 1989

Fetal Diagn Ther

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show abstract

“…After cordocentesis, the hematological find ings may be of considerable immediate diag nostic value [13,20,21]. Raised blood cell volumes as well as an abnormal distribution of the blood cell volumes are immediately detected with modern automated cell coun ters.…”

Section: ]mentioning

confidence: 99%

Hematological Features of Fetal Triploidy: A Report of 11 Cases

et al. 1997

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Using fetal blood sampling, the diagnosis of triploidy can be strongly suspected on the basis of the peculiar hematological picture. Triploid fetuses present with anemia, marked anisopoikilocytosis, and grossly increased mean corpuscular volume, associated with thrombocytopenia and significant platelet anisocytosis. These findings are of considerable immediate diagnostic value. They allow physicians to immediately counsel parents about the prognosis of the fetus. In case of fetal or neonatal distress, this information could orientate decisions about obstetrical and pediatric management while waiting for the definitive diagnosis.

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Relationship between cell size and nuclear volume in nucleated red blood cells of developmentally matched diploid and tetraploid mouse embryos

Henery

Kaufman

1992

J. Exp. Zool.

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Analysis of control diploid and polyploid amphibia indicated that cell and nuclear volumes were closely related to their ploidy, so that an increase in ploidy was generally associated with an increase in cell size. This relationship is also believed to occur in mammalian polyploids. However, since the latter are only rarely encountered spontaneously, or only occasionally following experimental manipulation, no detailed morphometric studies have been carried out to date to confirm whether such a relationship exists. In this study, the cellular and nuclear volume of primitive red blood cells was analyzed in carefully developmentally matched control diploid mouse embryos and tetraploid embryos produced by the technique of electrofusion. All of the cells and/or nuclei studied had a characteristic spherical shape which greatly simplified the morphometric analysis. A defined and predictable relationship between ploidy and cellular and/or nuclear volume was observed in the red blood cells between 8.25 and 14.5 days of gestation. During this period the primitive red blood cells are gradually replaced by the definitive erythrocytes. The ratio of control values to tetraploid values was found to be close to the theoretical value of 1:2 when comparable cells and/or their nuclei were analyzed in carefully developmentally matched material.

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Abnormal Hematologic Findings in Triploidy

Cited by 3 publications

References 7 publications

Mean Red Cell Volume in Normal, Anemic, Small, Trisomic and Triploid Fetuses

Mean Red Cell Volume in Normal, Anemic, Small, Trisomic and Triploid Fetuses

Hematological Features of Fetal Triploidy: A Report of 11 Cases

Relationship between cell size and nuclear volume in nucleated red blood cells of developmentally matched diploid and tetraploid mouse embryos

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