Abnormal Heart Rate Variability as a Manifestation of Autonomic Dysfunction in Hemispheric Brain Infarction

Korpelainen, Juha T.; Sotaniemi, K. A.; Huikuri, Heikki V.; Myllylä, Vilho V.

doi:10.1161/01.str.27.11.2059

Cited by 171 publications

(130 citation statements)

References 29 publications

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“…In patients with stroke, a disturbance in the autonomic functions caused by the lesion was often described to affect physiological processes in cerebrovascular diseases [38][39][40]. In the context of a decrease in HRV, i.e., SD of RR intervals, we found low frequency and high frequency for patients with stroke [38,40]. In addition, Korpelainen et al showed that skin temperature …”

Section: Influence Of Physical Activity Neurological Deficits and Msupporting

confidence: 49%

Efficacy of rehabilitation robotics for walking training in neurological disorders: A review

Tefertiller¹,

Pharo²,

Evans³

et al. 2011

JRRD

137

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Abstract-Robot-assisted treadmill training is an established intervention used to improve walking ability in patients with neurological disorders. Although it has been shown that attention to the task is a key factor for successful rehabilitation, the psychological state of patients during robot-assisted gait therapy is often neglected. We presented 17 nondisabled subjects and 10 patients with neurological disorders a virtual-reality task with varying difficulty levels to induce feelings of being bored, excited, and overstressed. We developed an approach to automatically estimate and classify a patient's psychological state, i.e., his or her mental engagement, in real time during gait training. We used psychophysiological measurements to obtain an objective measure of the current psychological state. Automatic classification was performed by a neural network. We found that heart rate, skin conductance responses, and skin temperature can be used as markers for psychological states in the presence of physical effort induced by walking. The classifier achieved a classification error of 1.4% for nondisabled subjects and 2.1% for patients with neurological disorders. Using our new method, we processed the psychological state data in real time. Our method is a first step toward real-time auto-adaptive gait training with potential to improve rehabilitation results by optimally challenging patients at all times during exercise.

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Section: Influence Of Physical Activity Neurological Deficits and Msupporting

confidence: 49%

Efficacy of rehabilitation robotics for walking training in neurological disorders: A review

Tefertiller¹,

Pharo²,

Evans³

et al. 2011

JRRD

137

View full text Add to dashboard Cite

show abstract

“…Many studies have reported that cardiac autonomic function is impaired in patients with ischemic stroke [11,18]. It has been suggested that autonomic cardiovascular failure is associated with the impairment of parasympathetic function in patients with stroke [19].…”

Section: Discussionmentioning

confidence: 99%

Association of autonomic nervous system functions with immune response and prognosis in acute ischemic stroke patients

Çiğdem¹,

Yıldız²,

Bakıcı³

et al. 2012

CMJ

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Aim. Cerebrovascular disease is the most commonly encountered condition which causes serious mortality and morbidity in neurological practice. It has been reported that heart rate variability declines in a cerebrovasculer disease, which shows that autonomic functions are affected. Autonomic nervous system has a significant role in monitoring immune status and controlling inflammation. Similarly, there are studies reporting that immune system is affected during acute phase of cerebrovascular diseases. In the present study, our aim was to investigate the effect of autonomic nervous system on immune response and prognosis in acute ischemic cerebrovascular diseases. Method. 44 patients with middle cerebral artery infarction and 44 healthy controls were included in this study. Autonomic nervous system was evaluated using a methodology analysing the heart rate variability based on frequency. In order to evaluate the effects on immun system, serum levels of interleukin 1β, interleukin 6, tumor necrosis factor alfa and interleukin 10 were measured on the 1 st , 3 rd , 7 th and 10 th day by ELISA. Prognosis was evaluated by Rankin scale after 3 months. Results. Compared to the controls, low frequency power in normalized units (LFnu) was found to be high, high frequency power in normalized units (HFnu) was found to be low and ratio of LFnu/HFnu was found to be high in the patients group. The increase being more marked in left middle cerebral artery infarctions, interleukin-6 level were increased on the 10 th day and interleukin-10 level was decreased at all days compared to baseline in all patients. Interleukin-1β and tumor necrosis factor α levels were lower in all patients but the decrease was more pronounced in patients having left middle cerebral artery infarction. There was no difference between the Rankin scores of the patients having right and left middle cerebral artery infarction. Conclusions. Ischemic cerebrovascular disease is associated with an effect on immune system. This impaired immun response can be correlated both with a decreased parasympathetic activity and an increased sympathetic activity particularly in patients with middle cerebral artery infarctions.Keywords: Stroke, heart rate variability, interleukin-1β, interleukin-6, interleukin-10, tumor necrosis factor alfa Özet Amaç. Serebrovasküler hastalık nöroloji pratiğinde en sık karşılaşılan ve ciddi morbidite ve mortaliteye sebep olan bir durumdur. Serebrovasküler hastalıkta otonom fonksiyonlarda etkilenmeyi gösteren kalp hızı değişkenliğinde azalma olduğu bildirilmektedir. Otonom sinir sistemi immun durumun monitörize edilmesinde ve inflamasyonun kontrolünde önemli rol oynar. Benzer şekilde serebrovasküler hastalıkların akut döneminde immün sistemin de etkilendiğini gösteren çalışmalar mevcuttur. Amacımız akut iskemik serebrovasküler hastalıklarda otonom sinir sistemi fonksiyonunun immun yanıt ve prognoza etkisini araştırmaktır. Yöntem. Çalışmaya orta serebral arter infarktı olan 44 hasta ve 44 sağlıklı birey alınmıştır. Otonom sinir sistemi...

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“…Korpelainen et al [209] от-мечают, что автономная кардиальная дисрегуляция может сохраняться в течение 6 и более месяцев после инсульта и служить причиной устойчи-вости аритмий. Е.С.…”

Section: заключениеunclassified

Препараты Метаболического Действия В Комплексной Терапии Цереброкардиального Синдрома При Ишемическом Инсульте

Прекина¹,

Самолькина²

2014

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Abnormal Heart Rate Variability as a Manifestation of Autonomic Dysfunction in Hemispheric Brain Infarction

Abstract: Hemispheric brain infarction seems to cause significant long-lasting damage to the cardiovascular autonomic regulatory system manifested as abnormalities of heart rate variability. Distorted heart rate variability in the acute phase of stroke may be prognostically unfavorable.

Cited by 171 publications

References 29 publications

Efficacy of rehabilitation robotics for walking training in neurological disorders: A review

Efficacy of rehabilitation robotics for walking training in neurological disorders: A review

Association of autonomic nervous system functions with immune response and prognosis in acute ischemic stroke patients

Препараты Метаболического Действия В Комплексной Терапии Цереброкардиального Синдрома При Ишемическом Инсульте

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