Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study

Sui, Shuang Ge; Wu, Ming Xiang; King, Mark; Zhang, Yan; Ling, Li; Xu, Jianming; Weng, Xuefei; Duan, Lian; Shan, Baoci; Li, Ling Jiang

doi:10.1111/j.1601-5215.2010.00459.x

Cited by 34 publications

(23 citation statements)

References 72 publications

(92 reference statements)

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“…Due to their post-hoc nature, we do not interpret these findings, but merely report them for completeness. These findings are consistent with the anatomical location, but not necessarily the direction, of previously reported associations between PTSD trauma load andgray matter volume of the postcentral gyrus, middle frontal gyrus, fusiform, gyrus and frontal inferior gyrus (Felmingham et al, 2009; Kroes, Rugg, Whalley, & Brewin, 2011a; Nardo et al, 2010; Sui et al, 2010; Tavanti et al, 2012). We also found structural volume withinthe cerebellum to be positively associated with greater endorsement of PTSD symptomatology.…”

Section: Discussionsupporting

confidence: 91%

“…Early studies showed reduced volume within the pregenual and subcallosal cortex, which also includes regions of the medial prefrontal and orbitofrontal cortex (Chen, Li, Xu, & Liu, 2009; Felmingham et al, 2009; Geuze et al, 2008; Sui et al, 2010; Tavanti et al, 2012; Thomaes et al, 2010), among women with PTSD compared to trauma-exposed women without PTSD (Rauch et al, 2003). This finding has been replicated across a number of studies (Chen et al, 2006; Eckart et al, 2011; Felmingham et al, 2009; Ferrari, Busatto, McGuire, & Crippa, 2008; Thomaes et al, 2010; Yamasue et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

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Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Weber¹,

Killgore²,

Rosso³

et al. 2013

Journal of Anxiety Disorders

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Posttraumatic stress disorder (PTSD) is associated with functional abnormalities within aneurocircuitry that includes the hippocampus, amygdala, and medial prefrontal cortex. Evidence of structural abnormalities within these regions, and their association with PTSD severity and symptom burden is, however, sparse. The present study evaluated the relation between indices of gray matter volume and PTSD symptom severity using voxel-based morphometry. Fifteen individuals meeting DSM-IV criteria for PTSDcompleted the Clinician Administered PTSD Scale and underwent structural magnetic resonance imaging. Greater PTSD severity and avoidance/numbing were correlated withincreasedgray matter volume of the right amygdala-hippocampal complex. Greater hyper-arousal was associated with reducedgray matter volume in the left superior medial frontal gyrus. Findings are consistent with current neurocircuitry models of PTSD, which posit that the disorder is associated with structural and functional variance within this distributed network.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Weber¹,

Killgore²,

Rosso³

et al. 2013

Journal of Anxiety Disorders

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“…The precentral gyrus is thought to be part of the so-called fear-related motor neurocircuitry (37,38) and has been shown to have a larger grey matter volume in rape victims with PTSD than without PTSD. In light of our present findings, this may potentially be mediated by levels of peritraumatic and post-traumatic dissociation (39). The fusiform gyrus is known to subserve visual imagery from a first-person perspective (40) and is involved in cognitive forms of emotion regulation (36).…”

Section: Discussionmentioning

confidence: 95%

Structural brain aberrations associated with the dissociative subtype of post‐traumatic stress disorder

Daniels

Frewen

Théberge

et al. 2015

Acta Psychiatr Scand

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“…By contrast, some studies exhibited that the deactivation of fusiform gyrus in PTSD involved in complex visual emotional processing (Bremner et al ., ), retrieval of emotionally valenced word pairs (Bremner, ) and movie‐induced positive emotional processing (Jatzko et al ., ). Additionally, structural MRI study of PTSD indicated that grey matter density of fusiform gyrus was significantly reduced in patients compared to healthy controls (Sui et al ., ). Failure to replicate the consistent fusiform gyrus responsivity may be due to different task paradigms or type II error associated with small sizes.…”

Section: Discussionmentioning

confidence: 97%

Course‐dependent response of brain functional alterations in men with acute and chronic post‐traumatic stress disorder: A follow‐up functional magnetic imaging study

Zhang

Zheng

et al. 2011

Asia-Pacific Psychiatry

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Introduction:The aim of this study was to investigate the neurofunctional alterations in both acute and chronic post-traumatic stress disorder (PTSD) resulting from the same stress experience. Methods: Brain responses to emotional trauma-related and neutral pictures with a symptom provocation task were measured using functional magnetic resonance imaging (fMRI). Twenty-four PTSD patients resulting from a mining accident and 14 controls exposed to the same accident without PTSD two months post-trauma were recruited. In the follow-up study 20 PTSD patients and 14 controls were also recruited after 24 months post-trauma. Correlations were conducted in PTSD between altered fMRI blood oxygenation level-dependent (BOLD) signals of areas extracted as regions of interest and three Clinician-Administered PTSD Scale (CAPS) subscores respectively. Results: In response to picture stimulus (traumatic negative pictures versus neutral pictures), the acute PTSD group showed greater activation in the bilateral posterior cingulate gyri, left precuneus, right fusiform and left parahippocampal gyrus than the chronic PTSD group (P < 0.001, cluster size > 20 voxels). In the acute PTSD group, BOLD signals of either posterior cingulate gyrus correlated positively with CAPS intrusion subscores. There was also no significant correlation between BOLD signals of five regions mentioned above in the chronic PTSD group and three CAPS subscores. Discussion: These findings suggested that brain circuits affected in acute PTSD may be more extended than chronic PTSD. The reason may due to the formation of traumatic memory in the acute phase of PTSD.

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Abnormal grey matter in victims of rape with PTSD in Mainland China: a voxel-based morphometry study

Cited by 34 publications

References 72 publications

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Voxel-based morphometric gray matter correlates of posttraumatic stress disorder

Structural brain aberrations associated with the dissociative subtype of post‐traumatic stress disorder

Course‐dependent response of brain functional alterations in men with acute and chronic post‐traumatic stress disorder: A follow‐up functional magnetic imaging study

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