Abnormal glucose tolerance is associated with diminished postload change in leptin levels in women

Madarász, Eszter; Tabák, Ádám G.; Szabó, Gábor; Lakatos, Péter; Kerényi, Zsuzsa; Tamás, Gyula

doi:10.1002/dmrr.1001

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…In the Brazilian study, higher leptin levels were positively correlated with insulin resistance (HOMA‐IR index) in children and adolescents (Gonzaga, Medeiros, de Carvalho, & Alves, ). In addition, the fasting leptin level is negatively associated with insulin sensitivity in women with a previous history of gestational diabetes mellitus (Madarász et al, ). Leptin also potentially exerts its function through an inflammatory pathway.…”

Section: Discussionmentioning

confidence: 99%

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

Duan

Jhang

et al. 2020

Molec Gen & Gen Med

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Background Obesity has become the main health issue in developed countries as it impacts life expectancy and increases mortality of cerebrovascular or cardiovascular diseases. The leptin is one of the adipokines which presents in the serum in proportion to the amount of adipose tissue and is translated from LEP gene. It involves in energy homeostasis, lipid and glucose metabolisms, modulation of immune systems, and thermogenesis. Many previous studies have revealed controversial results between LEP polymorphisms and leptin levels in different ages and ethnicities. Herein, we investigated the impacts of LEP polymorphism against leptin levels in Taiwanese subjects. Methods In 599 Taiwanese subjects, excluding clinically overt systemic disease, age below 18 years old, and C‐reactive protein (CRP) level of above 10 mg/L, few of LEP polymorphisms were genotyped with TaqMan SNP genotyping assays, were further analyzed for association with leptin level in univariate and multivariate linear regression analyses with Bonferroni correction for multiple tests in stratified groups. The univariate and stepwise multivariate linear regression analyses were performed to determine the coefficient of determinant of LEP polymorphisms over leptin level. Results Significant associations were found between LEP polymorphisms and leptin levels in obese women. Circulating leptin level was positively correlated with inflammatory, insulin resistance markers, and visceral obesity markers in all subjects. Furthermore, stratified and interaction analyses revealed that LEP polymorphisms, rs7799039 and rs2167270, were significantly associated with leptin levels in obese women—8%–10% of which could be explained by LEP polymorphisms. Conclusion The LEP polymorphisms are independently associated with leptin levels in Taiwanese obese women. Further, the genetic determinants for leptin levels may be different between obese and nonobese, and in different sex individuals. The obesity status and female sex may exert modification effect on transcription of LEP, particularly in obese women.

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Section: Discussionmentioning

confidence: 99%

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

Duan

Jhang

et al. 2020

Molec Gen & Gen Med

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“…Hyperglycemia, an indicator for abnormal glucose homeostasis, is related to diabetes, incidences of obesity, and cardiovascular risk, inducing peripheral insulin resistance [45]. Recent studies indicate that hyperglycemia-induced diabetic complications are likely from oxidative dysfunction and inflammatory effect [5, 6].…”

Section: Discussionmentioning

confidence: 99%

Antihypertriglyceridemia and Anti-Inflammatory Activities ofMonascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats

Shi

Liao

Pan

2011

Experimental Diabetes Research

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The rice fermented by Monascus, called red mold rice (RMR), and has a long tradition in East Asia as a dietary staple. Monascus-fermented dioscorea called red mold dioscorea (RMD) contains various metabolites to perform the ability of reducing oxidative stress and anti-inflammatory response. We used Wistar rats and induced diabetes by injecting streptozotocin (STZ, 65 mg/kg i.p.). RMD was administered daily starting six weeks after disease onset. Throughout the experimental period, significantly (P < .05) lowered plasma glucose, triglyceride, cholesterol, free fatty acid and low density lipoprotein levels were observed in the RMD-treated groups. The RMD-treated diabetic rats showed higher activities of glutathione disulfide reductase, glutathione reductase, catalase and superoxide dismutase (P < .05) in the pancreas compared with the diabetic control rats. RMD also inhibited diabetes-induced elevation in the levels of interleukin (IL)-1β, IL-6, interferon-γ and tumor necrosis factor-α. Pancreatic β-cells damaged by STZ in the RMD supplemented groups were ameliorated. The results of this study clearly demonstrated that RMD possesses several treatment-oriented properties, including the control of hyperglycemia, antioxidant effects, pancreatic β-cell protection and anti-inflammatory effects. Considering these observations, it appears that RMD may be a useful supplement to delay the development of diabetes and its complications.

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“…In our earlier study, we emphasized, impaired glucose tolerance (IGT) as an additional risk factor to optimal immune function in obesity. Further, a recent study stated IGT as an independent risk factor for postload leptin changes, which lead us to speculate IGT to be either a cause or consequence of leptin resistance [34]. However, the mechanism needs to be fully elucidated.…”

Section: Jak2mentioning

confidence: 98%

Role of Leptin in Immune Dysfunction in WNIN Obese Rats

Rajkumar¹

2013

Endocrinol Metab Synd

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Aim: Role of leptin in bringing about systemic immune response under obesity has so far been speculative. In the present study we addressed this question using genetically obese rats developed at our centre-WNIN/Ob and WNIN/ GR-Ob. Methodology: Both the lean (+/+) and homozygous obese animals (-/-) received either phosphate buffered saline or leptin. While another set of fed lean and obese served as controls. Effect of leptin on immune function was assessed in terms of splenic lymphocyte proliferative response to Concavalin A (Con A), splenic CD4/CD8 ratio and Nitric oxide (NO) production by macrophages. Further, we also studied if the effect of leptin on immune function was associated with changes in receptor OBR (Leptin receptor) and or JAK2 (Janus tyrosine kinase 2) total protein expression. Results: Lean animals of both the strains (WNIN/GR-Ob & WNIN/Ob lean) responded to leptin treatment, in terms of increased CD4/CD8 ratio and lipopolysaccharide stimulated peritoneal macrophage Nitric Oxide (NO) production (P<0.05), while splenic lymphocyte proliferative response (P<0.05) to Concavalin A upon leptin treatment was observed only in WNIN/GR-Ob lean animals. Furthermore, significant increase in obese receptor (OBR) protein expression and a trend for JAK2 protein expression (P=0.06) upon leptin treatment were seen in WNIN/GR-Ob and WNIN/Ob lean animals respectively. Conclusion: The data thus show that leptin resistance could be one of the factors associated with immune dysfunction in obese condition.

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Abnormal glucose tolerance is associated with diminished postload change in leptin levels in women

Abstract: Disturbed leptin changes were found following an OGTT in women with abnormal glucose tolerance that might be either a cause or a consequence of leptin resistance.

Cited by 6 publications

References 28 publications

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

Modification effect of sex and obesity on the correlation of LEP polymorphisms with leptin levels in Taiwanese obese women

Antihypertriglyceridemia and Anti-Inflammatory Activities ofMonascus-Fermented Dioscorea in Streptozotocin-Induced Diabetic Rats

Role of Leptin in Immune Dysfunction in WNIN Obese Rats

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