Abnormal gastroduodenal motility in children and adolescents with recurrent functional abdominal pain

Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats

“…Liver is the primary site involved in the metabolism of various drugs and chemicals including carbamates (5). In addition, kidney and reproductive functions have been reported to be adversely affected with carbamate exposure to rats (6,7).…”

Low-dietary fiber intake as a risk factor for recurrent abdominal pain in children

“…Later, Dimson (1972), making use of the crimson rose colored test, observed a lateness in the time of intestinal transit. Other studies have shown an increase in intestinal transit; an exacerbated motor response to pharmacological stimulation and duodenal contractions of large amplitude (Dimson, 1972;Piñeiro-Careiro et al, 1988;Christensen, 1994). In this context, recent studies have been showing that children with RAP present visceral hyper-sensibility (Di Lorenzo et al, 2001;Van Ginkel et al, 2001) and peripheral hypersensibility (Duarte et al, 2000) that is currently considered one of the most important factors in the physiopathology of functional disturbances of the digestive system.…”

Влияние 5-Амино-4-(1,3-Бензотиазол-2-Ин)-1-(3-Метоксифенил)-1,2-Дигидро-3h-Пиррол-3-Она На Состояние Органов Пищеварения При Экспериментальном Раке Толстого Кишечника Крыс

“…Îðãàíû ïèùåâàðåíèÿ ïåð-âûìè ïîäâåðãàþòñÿ âîçäåéñòâèþ âåùåñòâ ýêçîãåííîãî ïðîèñõîaeäåíèÿ, â òîì ÷èñëå ëåêàðñòâåííûõ ïðåïàðàòîâ, ïðè èõ ïåðîðàëüíîì ïðèìåíåíèè, è èìåííî ñî ñòîðîíû ïèùåâàðèòåëüíîé ñèñòåìû íàáëþäàåòñÿ áîëüøèíñòâî ïîáî÷íûõ ýôôåêòîâ ïðîòèâîîïóõîëåâîé òåðàïèè. Ýòî ñâÿçàíî ñ ïîâûøåííîé ÷óâñòâèòåëüíîñòüþ ýïèòåëèÿ aeå-ëóäî÷íî-êèøå÷íîãî òðàêòà (AEÊÒ) ê âîçäåéñòâèþ öèòî-ñòàòèêîâ âñëåäñòâèå åãî âûñîêîé ïðîëèôåðàòèâíîé àê-òèâíîñòè [9], à òàêaeå ñ óÿçâèìîñòüþ ïå÷åíè, îáåñïå÷è-âàþùåé ïðîöåññû äåòîêñèêàöèè êñåíîáèîòèêîâ [15].…”

“… ñûâîðîòêå îïðåäåëÿëè àêòèâíîñòü àëàíèíàìèíîòðàíñôåðàçû (2.6.1.2; ÀËÒ), àñïàðòàòàìèíîòðàíñôåðàçû (2.6.1.1; ÀÑÒ), ùåëî÷íîé ôîñôàòàçû (3.1.3.1; ÙÔ) è ëàêòàòäå-ãèäðîãåíàçû (1.1.1.27; ËÄÃ), ÿâëÿþùèõñÿ âûñîêî÷óâñò-âèòåëüíûìè ïîêàçàòåëÿìè ñîñòîÿíèÿ ïå÷åíè, ñ ïîìî-ùüþ ñòàíäàðòíûõ òåñò-íàáîðîâ ðåàêòèâîâ ("Ðåàãåíò", Óêðàèíà). Êîýôôèöèåíò äå Ðèòèñà îïðåäåëÿëè êàê ñîîò-íîøåíèå ÀÑÒ/ÀËÒ [15].…”

“…Îðãàíû ïèùåâàðåíèÿ ïåð-âûìè ïîäâåðãàþòñÿ âîçäåéñòâèþ âåùåñòâ ýêçîãåííîãî ïðîèñõîaeäåíèÿ, â òîì ÷èñëå ëåêàðñòâåííûõ ïðåïàðàòîâ, ïðè èõ ïåðîðàëüíîì ïðèìåíåíèè, è èìåííî ñî ñòîðîíû ïèùåâàðèòåëüíîé ñèñòåìû íàáëþäàåòñÿ áîëüøèíñòâî ïîáî÷íûõ ýôôåêòîâ ïðîòèâîîïóõîëåâîé òåðàïèè. Ýòî ñâÿçàíî ñ ïîâûøåííîé ÷óâñòâèòåëüíîñòüþ ýïèòåëèÿ aeå-ëóäî÷íî-êèøå÷íîãî òðàêòà (AEÊÒ) ê âîçäåéñòâèþ öèòî-ñòàòèêîâ âñëåäñòâèå åãî âûñîêîé ïðîëèôåðàòèâíîé àê-òèâíîñòè [9], à òàêaeå ñ óÿçâèìîñòüþ ïå÷åíè, îáåñïå÷è-âàþùåé ïðîöåññû äåòîêñèêàöèè êñåíîáèîòèêîâ [15].Íàèáîëåå ðàñïðîñòðàíåííûì ìåòîäîì ëå÷åíèÿ íå-îïëàçèé ÿâëÿåòñÿ õèìèîòåðàïèÿ, êîòîðàÿ îáëàäàåò âûñî-êîé ÷àñòîòîé ïîáî÷íûõ ýôôåêòîâ [9].  ïîñëåäíåå âðåìÿ ïðèâëåêàþò âíèìàíèå èíãèáèòîðû ïðîòåèíêèíàç êàê ñïåöèôè÷åñêèå èíãèáèòîðû ïðîëèôåðàòèâíîé àêòèâíî-ñòè, îáëàäàþùèå ñïåöèôè÷åñêèì âîçäåéñòâèåì íà òðàíñôîðìèðîâàííûå êëåòêè è íåçíà÷èòåëüíîé òîêñè÷-íîñòüþ ïî îòíîøåíèþ ê íîðìàëüíûì êëåòêàì îðãàíèç-ìà.…”