Abnormal functional integration across core brain networks in migraine without aura

Yu, Dahua; Yuan, Kai; Luo, Lin; Zhai, Jinquan; Bi, Yanzhi; Xue, Ting; Ren, Xiaoying; Zhang, Ming; Ren, Guoyin; Lu, Xiaoqi

doi:10.1177/1744806917737461

Cited by 36 publications

(40 citation statements)

References 43 publications

(106 reference statements)

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“…The SN plays a critical role in the functional integration between RSNs . FC analysis showed significant increases in FC between the left and right INS in OB compared with NW, contributing to the disruption of FC within the SN.…”

Section: Discussionmentioning

confidence: 97%

Altered Interactions Among Resting‐State Networks in Individuals with Obesity

Ding

et al. 2020

Obesity

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Objective The aim of this study was to investigate alterations in functional connectivity (FC) within and interactions between resting‐state networks involved in salience, executive control, and interoception in participants with obesity (OB). Methods Using resting‐state functional magnetic resonance imaging with independent component analysis and FC, alterations within and interactions between resting‐state networks in 35 OB and 35 normal‐weight controls (NW) were investigated. Results Compared with NW, OB showed reduced FC strength in the ventromedial prefrontal cortex and posterior cingulate cortex/precuneus within the default‐mode network, dorsal anterior cingulate cortex within the salience network (SN), bilateral dorsolateral prefrontal cortex‐angular gyrus within the frontoparietal network (FPN), and increased FC strength in the insula (INS) (Pfamilywise error < 0.0125). The dorsal anterior cingulate cortex FC strength was negatively correlated with craving for food cues, left dorsolateral prefrontal cortex FC strength was negatively correlated with Yale Food Addiction Scale scores, and right INS FC strength was positively correlated with craving for high‐calorie food cues. Compared with NW, OB also showed increased FC between the SN and FPN driven by altered FC of bilateral INS and anterior cingulate cortex‐angular gyrus. Conclusions Alterations in FC within and interactions between the SN, default‐mode network, and FPN might contribute to the high incentive value of food (craving), lack of control of overeating (compulsive overeating), and increased awareness of hunger (impaired interoception) in OB.

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Section: Discussionmentioning

confidence: 97%

Altered Interactions Among Resting‐State Networks in Individuals with Obesity

Ding

et al. 2020

Obesity

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“…Several studies in episodic migraine concordantly found that DMN is less connected between attacks of migraine without aura [37,38]. Whereas, the intrinsic functional connectivity of the DAS was reduced [39] in episodic migraine interictally and less connected with the DMN [9].…”

Section: Discussionmentioning

confidence: 87%

Haemodynamic Activity Characterization of Resting State Networks by Fractal Analysis and Thalamocorticalmorpho functional Integrity in Chronic Migraine

Porcaro

Renzo

Tinelli

et al. 2020

Preprint

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Abstract Background - Chronic migraine (CM)can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level dependent (BOLD) activity maybe used to estimatethe complexity of RSNs, reflecting flexibility and/or efficiency in information processing in CM patients respect to healthy controls (HC).Methods -Resting-state MRI data were collected from 20 untreated CM without history of medication overuse and 20 HC. On both groups, we estimated the Higuchi’sFD. On the same subjects,fractional anisotropy (FA) and mean diffusivity (MD)values of bilateral thalami were retrieved from diffusion tensor imaging andcorrelated with the FD values.Results - CM showed higher FD values within dorsal attention system (DAS) and the anterior part of default-mode network (DMN), and lower FD values within the posterior DMN compared to HC.Although FA and MD were within the range of normality, both correlated with the FD values of DAS.Conclusions - FDof DAS and DMN may reflect disruption of cognitive control of pain in CM.Normal microstructure of the thalamus and its positive connectivity with the cortical networking may be yet another evidence in supporting CM as a never-ending migraine attack.

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“…Several studies in episodic migraine concordantly found that DMN is less connected between attacks of migraine without aura [45,46]. Whereas, the intrinsic functional connectivity of the DAS was reduced [47] in episodic migraine interictally and less connected with the DMN [9].…”

Section: Discussionmentioning

confidence: 87%

Haemodynamic activity characterization of Resting State Networks by Fractal Analysis and thalamocortical morphofunctional integrity in chronic migraine

Porcaro

Renzo

Tinelli

et al. 2020

Preprint

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Background Chronic migraine (CM) can be associated with aberrant long-range connectivity of MRI-derived resting-state networks (RSNs). Here, we investigated how the fractal dimension (FD) of blood oxygenation level dependent (BOLD) activity may be used to estimate the complexity of RSNs, reflecting flexibility and/or efficiency in information processing in CM patients respect to healthy controls (HC). Methods Resting-state MRI data were collected from 20 untreated CM without history of medication overuse and 20 HC. On both groups, we estimated the Higuchi’s FD. On the same subjects, fractional anisotropy (FA) and mean diffusivity (MD) values of bilateral thalami were retrieved from diffusion tensor imaging and correlated with the FD values. Results CM showed higher FD values within dorsal attention system (DAS) and the anterior part of default-mode network (DMN), and lower FD values within the posterior DMN compared to HC. Although FA and MD were within the range of normality, both correlated with the FD values of DAS. Conclusions FD of DAS and DMN may reflect disruption of cognitive control of pain in CM. Since the normal microstructure of the thalamus and its positive connectivity with the cortical networking found in our CM patients reminds similar results obtained assessing the same structures but with the methods of neurophysiology, in episodic migraine during an attack, this may be yet another evidence in supporting CM as a never-ending migraine attack.

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Abnormal functional integration across core brain networks in migraine without aura

Cited by 36 publications

References 43 publications

Altered Interactions Among Resting‐State Networks in Individuals with Obesity

Altered Interactions Among Resting‐State Networks in Individuals with Obesity

Haemodynamic Activity Characterization of Resting State Networks by Fractal Analysis and Thalamocorticalmorpho functional Integrity in Chronic Migraine

Haemodynamic activity characterization of Resting State Networks by Fractal Analysis and thalamocortical morphofunctional integrity in chronic migraine

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