Abnormal fronto-striatal intrinsic connectivity reflects executive dysfunction in alcohol use disorders

Galandra, Caterina; Basso, Gianpaolo; Manera, Marina; Crespi, Chiara; Giorgi, Inés; Vittadini, G; Poggi, Paolo; Canessa, Nicola

doi:10.1016/j.cortex.2019.01.004

Cited by 34 publications

(48 citation statements)

References 85 publications

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“…In line with this evidence, other studies reported an association between attentional/executive deficits and glucose metabolism in the anterior cingulate cortex (ACC) in alcoholics (Goldstein et al, 2004). Altogether, the aforementioned findings consistently suggest that AUD patients' executive impairment might reflect anatomofunctional alterations involving the salience network (SN) (Galandra et al, 2018b(Galandra et al, , 2019. The latter, indeed, underpins the switch from automatic to controlled effortful processing, associated with the activity of the default-mode network (DMN) and central executive network (CEN), respectively, when relevant stimuli are detected (Smith et al, 2009;Menon and Uddin, 2010;Goulden et al, 2014).…”

Section: Introductionsupporting

confidence: 53%

“…The ENB returns a global score, as well as different sub-scores for each task. The analysis of the resulting neuropsychological data has been previously described by Galandra and colleagues (Galandra et al, 2018b(Galandra et al, , 2019 and reported in Supplementary Table S1.…”

Section: Clinical Interview Neuropsychological Evaluation and Data mentioning

confidence: 99%

“…On this basis, we aimed to investigate whether ICs differentiating patients from HC additionally confirmed the involvement of salience network regions as neurostructural markers of the neuro-cognitive impairment associated with AUD (Galandra et al, 2018b(Galandra et al, , 2019. To this purpose, we finally correlated mixing coefficients with (1) a measure of each participant's executive profile, obtained via a multivariate data reduction approach (see Galandra et al, 2018b for detailed information about the statistical procedure) and (2) clinical variables (i.e., lifetime duration of alcohol abuse and daily alcohol consumption) in AUD patients.…”

Section: Joint Independent Component Analysismentioning

confidence: 99%

“…It is still unknown, however, whether impaired executive profile in AUD reflects a multimodal pattern of neurostructural damage transcending single MRI metrics. Preliminary attempts toward this goal have been pursued by distinct studies relating a global proxy of basic executive functioning (involving psychomotor speed, attention and working memory performances) to the degree of GM atrophy in meso-cortico-limbic structures (Galandra et al, 2018b), and altered functional connectivity in frontostriatal-limbic networks (Galandra et al, 2019). In line with this evidence, other studies reported an association between attentional/executive deficits and glucose metabolism in the anterior cingulate cortex (ACC) in alcoholics (Goldstein et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…We expected to reconcile separate single-modality findings (Galandra et al, 2018b(Galandra et al, , 2019 into a unique consistent framework in which the ICs differentiating AUD patients from HC reflect neurostructural alterations of nodes and connections involving the salience network, with their mixing coefficient reflecting the degree of patients' executive impairment.…”

Section: Introductionmentioning

confidence: 99%

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Executive Impairment in Alcohol Use Disorder Reflects Structural Changes in Large-Scale Brain Networks: A Joint Independent Component Analysis on Gray-Matter and White-Matter Features

et al. 2019

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Alcohol Use Disorder (AUD) entails chronic effects on brain structure. Neurodegeneration due to alcohol toxicity is a neural signature of executive impairment typically observed in AUD, previously related to both gray-matter volume/density and white-matter abnormalities. Recent studies highlighted the role of meso-cortico-limbic structures supporting the salience and executive networks, in which the extent of neurostructural damage is significantly related to patients' executive performance. Here we aim to integrate multimodal information on gray-matter and white-matter features with a multivariate data-driven approach (joint Independent Component Analysis, jICA), and to assess the relationship between the extent of damage in the resulting neurostructural superordinate components and executive profile in AUD. Twenty-two AUD patients and 18 matched healthy controls (HC) underwent a Magnetic Resonance Imaging (MRI) protocol, alongside clinical and neuropsychological examinations. We ran jICA on five neurostructural features, including gray-matter density and different diffusion tensor imaging metrics. We extracted 12 Independent Components (ICs) and compared the resulting mixing coefficients in patients vs. HC. Finally, we correlated significant ICs with executive and clinical variables. One out of 12 ICs (IC11) discriminated patients from healthy controls and correlated positively both with executive performance in all subjects, and with lifetime duration of alcohol abuse in patients. In line with previous related evidence, this component involved widespread gray-matter and white-matter patterns including key nodes and fiber tracts of salience, default-mode and central executive networks. These findings highlighted the role of multivariate data integration as a valuable approach revealing superordinate hallmarks of neural changes related to cognition in neurological and psychiatric populations.

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Section: Introductionsupporting

confidence: 53%

Section: Clinical Interview Neuropsychological Evaluation and Data mentioning

confidence: 99%

Section: Joint Independent Component Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Executive Impairment in Alcohol Use Disorder Reflects Structural Changes in Large-Scale Brain Networks: A Joint Independent Component Analysis on Gray-Matter and White-Matter Features

et al. 2019

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Dynamic frontostriatal functional peak connectivity (in alcohol use disorder)

Gerchen

Weiss

Kirsch

et al. 2020

Human Brain Mapping

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Alcohol use disorder (AUD) is associated with changes in frontostriatal connectivity, but functional magnetic resonance imaging (fMRI) functional connectivity (FC) approaches are usually not adapted to these circuits. We developed a circuitspecific fMRI analysis approach to detect dynamic changes in frontostriatal FC inspired by medial-ventral-rostral to lateral-dorsal-caudal frontostriatal gradients originally identified in nonhuman primate tract-tracing data. In our PeaCoG ("peak connectivity on a gradient") approach we use information about the location of strongest FC on empirical frontostriatal connectivity gradients. We have recently described a basic PeaCoG version with conventional FC, and now developed a dynamic PeaCoG approach with sliding-window FC. In resting state data of n = 66 AUD participants and n = 40 healthy controls we continue here the analyses that we began with the basic version. Our former result of an AUD-associated ventral shift in right orbitofrontal cortex PeaCoG is consistently detected in the dynamic approach. Temporospatial variability of dynamic PeaCoG in the left dorsolateral prefrontal cortex is reduced in AUD and associated with self-efficacy to abstain and days of abstinence. Our method has the potential to provide insight into the dynamics of frontostriatal circuits, which has so far been relatively unexplored, and into their role in mental disorders and normal cognition.

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Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

Presti

Origlia

Gianelli

et al. 2023

Human Brain Mapping

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While mounting evidence shows promising effects of brain training on cognitive functioning in healthy and pathological conditions, the spread of variable training approaches highlights the need to compare their efficacy and identify their neural correlates, representing possible targets for neuromodulation treatments. We performed coordinate‐based functional magnetic resonance imaging meta‐analyses to compare the neural correlates and the cognitive outcomes of cognitive (n = 22), physical (n = 22), and meditative (n = 20) training in healthy non‐expert individuals. Pre/post‐training cognitive metrics improved after cognitive and physical training, but their heterogeneity, or even the lack of these measurements in some studies, highlights the need of more structured protocols. Cognitive, physical, and meditative interventions increased brain activity in distinct fronto‐medial areas likely mediating training effects on cognitive, action, and attentional control, respectively. The modular, training‐specific, engagement of a region that is known to mediate feedback‐based learning provides cues for boosting brain training via combined interventions that might jointly outperform their individual effects.

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Abnormal fronto-striatal intrinsic connectivity reflects executive dysfunction in alcohol use disorders

Cited by 34 publications

References 85 publications

Executive Impairment in Alcohol Use Disorder Reflects Structural Changes in Large-Scale Brain Networks: A Joint Independent Component Analysis on Gray-Matter and White-Matter Features

Executive Impairment in Alcohol Use Disorder Reflects Structural Changes in Large-Scale Brain Networks: A Joint Independent Component Analysis on Gray-Matter and White-Matter Features

Dynamic frontostriatal functional peak connectivity (in alcohol use disorder)

Cognition, body, and mind: A three‐in‐one coordinate‐based fMRI meta‐analysis on cognitive, physical, and meditative trainings

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