Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study

Adler, Caleb M.; Holland, Scott K.; Schmithorst, Vince; Wilke, Marko; Weiss, Kenneth L.; Pan, Hai; Strakowski, Stephen M.

doi:10.1111/j.1399-5618.2004.00108.x

Cited by 195 publications

(141 citation statements)

References 38 publications

(41 reference statements)

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“…Reduced gray matter in the IFC has been reported in several studies (Lopez-Larson et al, 2002;Lyoo et al, 2004;Foland-Ross et al, 2011), and reduced frontal gray matter density may provide an explanation for the functional abnormalities seen in patients with bipolar disorder across mood states. Alternatively, deficits in white matter tracts (Adler et al, 2004;Beyer et al, 2005) or white matter volume (Kieseppa et al, 2003) could also result in a disruption of normal activation in this frontal-striatal circuit. The precise mechanism requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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Section: Discussionmentioning

confidence: 99%

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Penfold¹,

Vizueta²,

Townsend³

et al. 2015

Psychiatry Research: Neuroimaging

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“…Changes that disrupt the tracts connecting critical regions involved in mood regulation may contribute to the pathogenesis of bipolar disorder. Adler et al (2004) conducted a DTI study in bipolar patients focusing on prefrontal regions. They evaluated samplings of the white matter tracts extending above the anterior commissure, of which the most superior were located near our sampling for the SFGs.…”

Section: Discussionmentioning

confidence: 99%

Cortical White Matter Microstructural Abnormalities in Bipolar Disorder

Beyer

Taylor

MacFall

et al. 2005

Neuropsychopharmacol

144

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This article reports on preliminary findings describing microstructural abnormalities in the white matter of cortical areas thought to be associated with bipolar disorder. In all, 14 patients with bipolar disorder and 21 nonpsychiatrically ill control subjects underwent MR imaging including a diffusion tensor imaging (DTI) pulse sequence (six directions, b ¼ 1000 mm 2 /s). DTI data were analyzed on a workstation using a program that allowed calculation of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) within the following three white matter fiber tracts bilaterally: the orbital frontal cortex, and the superior and middle frontal gyri. These values were compared across patient groups. The left and right orbital frontal white matter exhibited significantly higher ADC values in bipolar subjects than control subjects on both the left (p ¼ 0.028) and right (p ¼ 0.011). Microstructural changes in the white matter of the orbital frontal areas as reflected by increased ADC values appear to be associated with bipolar disorder. Further research is needed to better understand the interaction of microstructural changes and bipolar symptoms and whether these changes are specific to bipolar disorder.

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“…25 Kanaan et al 59 have underlined the controversial use of ROI approaches because of the great variability of WM tracts and the lack of anatomical landmarks to draw them. This methodological shortcoming might explain the rather contradictory findings of DTI studies in BP, reporting predominantly increased ADC or decreased FA in frontal WM [19][20][21] with one study reporting increased as well as decreased FA in different ROIs. 22 The present findings have to be interpreted in light of some limitations.…”

Section: Diffusion Tensor Tractography In Bipolar Patients J Houenou mentioning

confidence: 99%

“…[19][20][21][22] As the amount of FA has been shown to be an indirect measures of the directionality and coherence of fiber tracts, 23,24 DTI studies in BP suggest a loss of coherence in frontal WM bundles. However, these studies have investigated predefined and limited regions of interest (ROIs), representing only a part of a specific WM bundles and might thus be susceptible to overlook subtle differences between study groups.…”

Section: Introductionmentioning

confidence: 99%

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

et al. 2007

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Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age-and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

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Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study

Abstract: Our findings suggest that a loss of bundle coherence is present in prefrontal white matter. This loss of coherence may contribute to prefrontal cortical pathology in patients with bipolar disorder.

Cited by 195 publications

References 38 publications

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Frontal lobe hypoactivation in medication-free adults with bipolar II depression during response inhibition

Cortical White Matter Microstructural Abnormalities in Bipolar Disorder

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

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