Abnormal fixational eye movements in strabismus

Ghasia, Fatema F.; Otero‐Millan, Jorge; Shaikh, Aasef G.

doi:10.1136/bjophthalmol-2017-310346

Cited by 37 publications

(63 citation statements)

References 35 publications

(6 reference statements)

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“…This disconjugacy was greater for patients with large-angle strabismus and impaired stereopsis (as a result of the misalignment of their eyes) than for patients with small-angle strabismus and preserved stereopsis (Figure 4 ). This study also found that drift was faster in patients with strabismus than in control subjects ( 46 ).…”

Section: Microsaccades In Ophthalmic Diseasesupporting

confidence: 53%

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Microsaccade Characteristics in Neurological and Ophthalmic Disease

2018

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Microsaccade research has recently reached a critical mass of studies that allows, for the first time, a comprehensive review of how microsaccadic dynamics change in neurological and ophthalmic disease. We discuss the various pathological conditions that affect microsaccades, their impact on microsaccadic and other fixational eye movement dynamics, and the incipient studies that point to microsaccadic features as potential indicators of differential and early diagnoses of multiple clinical conditions, from movement disorders to attention-deficit hyperactivity disorder to amblyopia. We propose that the objective assessment of fixational eye movement parameters may help refine differential diagnostics in neurological disease and assist in the evaluation of ongoing therapy regimes. In addition, determining the effects of ophthalmic disease on fixational eye movement features may help evaluate visual impairment in an objective manner, particularly in young patients or those experiencing communication difficulties.

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Section: Microsaccades In Ophthalmic Diseasesupporting

confidence: 53%

“…Black arrows indicate microsaccades, and gray arrows represent intersaccadic drift. From Ghasia et al ( 46 ).…”

Section: Microsaccades In Ophthalmic Diseasementioning

confidence: 99%

Microsaccade Characteristics in Neurological and Ophthalmic Disease

2018

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“…Blinks were identified and removed, as for the 200 milliseconds of data before and after them. Fixational saccades and quick phases of nystagmus were identified using an unsupervised clustering method [15,19,41]. The saccades amplitude is the absolute difference between eye positions at the start and end of a fixational saccade in patients without nystagmus or quick phase in patients with nystagmus.…”

Section: Eye Movement Recording and Analysismentioning

confidence: 99%

“…The increase in fixation instability is detrimental to vision as shown by reduced visual acuity and reading speeds when simulating eye position instability [9,10]. Patients with amblyopia have an increase in fixation instability [11][12][13][14][15][16][17]. This instability could arise from the presence of nystagmus or due to increased amplitude of involuntary saccades and inter saccadic drifts elicited during fixation [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Part time patching treatment outcomes in children with amblyopia with and without fusion maldevelopment nystagmus: An eye movement study

et al. 2020

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We investigated how the abnormalities of fixation eye movements (FEMs) of the amblyopic eye were linked with treatment outcomes following part-time patching therapy in children with amblyopia. Methods We recruited 53 patients, with at least 12 months of patching, and measured FEMs at the end of treatment. Subjects were classified based on FEM waveforms (those without nystagmus = 21, those with nystagmus without fusion maldevelopment nystagmus (FMN) = 21, and those with FMN = 11) and based on clinical type of amblyopia (anisometropic = 18, strabismic = 6, and mixed = 29). The treatment outcomes such as duration of treatment of receiving part-time patching therapy, visual acuity and stereo-acuity deficits at the end of treatment were determined. Bivariate contour ellipse area (BCEA), fast (fixational saccade/ quick phases), and slow (inter-saccadic drifts/slow phases) FEMs of the fellow and amblyopic eye were analyzed. Results Anisometropic group had less residual amblyopia (0.23±0.19logMAR acuity) compared to strabismic/mixed (0.36±0.26) groups (p = 0.007). Treatment duration in patients without nystagmus was lower (12.6±9.5months) compared to nystagmus without FMN (25.6±23.2) and FMN (29.5±20.4) groups (p = 0.006). Patients without nystagmus had better stereopsis at the end of treatment (2.3±0.84logarcsecs) compared to nystagmus without FMN (2.6

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“…A high-resolution video-based eye tracker (EyeLink 1000) was used as described in our previous work. 31,32 The experiment protocols complied with the tenets of the Declaration of Helsinki and were approved by the Cleveland Clinic Institutional Review Board. Written informed consent was obtained from the parents or legal guardians on behalf of all the children.…”

Section: Eye Movement Recordingsmentioning

confidence: 99%