Abnormal fatty acid composition in the frontopolar cortex of patients with affective disorders

Tatebayashi, Yoshitaka; Nihonmatsu-Kikuchi, Naomi; Hayashi, Yoshitaka; Yu, Xinguang; Soma, Masaaki; Ikeda, Kazutaka

doi:10.1038/tp.2012.132

Cited by 30 publications

(21 citation statements)

References 38 publications

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“…We could not determine whether the results that we observed were due to the effects of psychotropic drugs, although NIRS signals were not correlated with drug dosage. For example, a very recent study reported that carbamazepine extended-release treatment normalized frontopolar activation in manic youths with BD [55], and that postmortem brain tissue from medicated patients with BD exhibited impaired myelination in the frontopolar cortex [56]. Thus, there remains a possibility that the association found in this study was due to the treatment and the long-term course of the disorder.…”

Section: Discussionmentioning

confidence: 84%

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Nishimura¹,

Takahashi²,

Ohtani³

et al. 2015

Neuropsychobiology

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Background: It is important to understand the neural basis of functional impairments in patients with bipolar disorder (BD) in order to be able to address the recovery. Recently, neurocognitive impairment emerged as a predictor of psychosocial function. A number of functional brain imaging studies have shown that social function is associated with activation of the prefrontal cortex during a cognitive task in healthy adults, and in patients with major depressive disorder and schizophrenia. However, few studies have been conducted in patients with BD. Methods: We performed multichannel near-infrared spectroscopy (NIRS) imaging to investigate the activation of the prefrontal cortex during a verbal fluency task (VFT). We also used the Social Adaptation Self-Evaluation Scale (SASS) to assess social functioning in patients with BD. Thirty-three depressed patients with BD and 65 age-, gender- and task performance-matched healthy controls (HCs) participated in this study. Results: Depressed patients with BD showed reduced activation in the broader bilateral prefrontal cortex during the VFT compared to HCs. Moreover, a significant positive correlation was observed between the total SASS scores and right prefrontal activation in patients with BD. In the SASS subscores, the interest and motivation factor was also positively correlated with frontopolar activation. Conclusions: These results suggest an association between social function and prefrontal activation in depressed patients with BD. The present study provides evidence that NIRS imaging could be helpful in understanding the neural basis of social function.

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Section: Discussionmentioning

confidence: 84%

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Nishimura¹,

Takahashi²,

Ohtani³

et al. 2015

Neuropsychobiology

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“…Our data shows that the metabolism of sphingolipids and phospholipids is significantly altered by stress in both the PFC and the hippocampus, suggesting SMase, PLA2 and PLD as potential therapeutical targets for stress-related disorders. These alterations in lipid signaling pathways have several implications in physiological mechanisms, such as, neurogenesis and synaptic plasticity, known to be implicated in several stress-related disorders, such as emotional disorders 15, 49–51 , and eventually other psychiatric disorders, such as schizophrenia 51–54 . Given that there are different SMase, PLA2 and PLD isozymes, future lipidomic studies addressing the impact of lipid signaling-targeted therapeutical drugs will provide the pharmacological mechanistic insights in order to choose the best candidate drug in a given pathological condition.…”

Section: Discussion/conclusionmentioning

confidence: 99%

The impact of chronic stress on the rat brain lipidome

et al. 2015

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Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision making and emotional responses, and may even predispose for pathological processes, such as Alzheimer’s disease (AD) and depression. Lipids are a major constituent of the brain, and specifically signaling lipids have been shown to regulate brain function. Here, we used a mass spectrometry-based lipidomic approach to evaluate the impact of a chronic unpredictable stress paradigm on the rat brain in a region-specific manner. We found that the prefrontal cortex (PFC) was the area with the highest degree of changes induced by chronic stress. Although the hippocampus presented relevant lipidomic changes, the amygdala and to a more extent, the cerebellum, presented few lipid changes upon chronic stress exposure. The sphingolipid and phospholipid metabolism were profoundly affected, showing an increase in ceramide and a decrease in sphingomyelin and dihydrosphingomyelin levels, and decreased phosphatidylethanolamine and ether phosphatidylcholine and increased lysophosphatidylethanolamine levels, respectively. Furthermore, the fatty acyl profile of phospholipids and diacylglycerol revealed that chronic stressed rats had higher 38 carbon(38C)-lipid levels in the hippocampus and a decrease in 36C-lipid levels in the PFC. Finally, lysophosphatidylcholine levels in the PFC were found to be correlated with blood corticosterone levels. In summary, lipidomic profiling of the effect of chronic stress allowed for the identification of dysregulated lipid pathways, revealing putative targets for pharmacological intervention that may potentially be used to modulate stress-induced deficits.

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“…It remains to be determined whether PUFA-modulated signaling pathways influence the molecular responses in oligodendrocyte lineage cells in response to behavioral experiences, so additional studies are needed to understand if, and how, these "inputs" may converge at the molecular level. However, abnormalities in the composition of PUFAs have been identified in the frontopolar cortex of bipolar and major disorder patients (Tatebayashi et al, 2012). Analysis of PUFA content in erythrocytes and diffusion tensor imaging performed in patients with psychotic disorders established a correlation of decreased PUFAs and fractional anisotropy, a measurement of water movement correlated with white matter integrity (Peters et al, 2013).…”

Section: Common Effectors? the Potential For Intersecting Mechanisms mentioning

confidence: 99%

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

2016

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Many behavioral experiences are known to promote hippocampal neurogenesis. In contrast, the ability of behavioral experiences to influence the production of oligodendrocytes and myelin sheath formation remains relatively unknown. However, several recent studies indicate that voluntary exercise and environmental enrichment can positively influence both oligodendrogenesis and myelination, and that, in contrast, social isolation can negatively influence myelination. In this review we summarize studies addressing the influence of behavioral experiences on oligodendrocyte lineage cells and myelin, and highlight potential mechanisms including experience-dependent neuronal activity, metabolites, and stress effectors, as well as both local and systemic secreted factors. Although more study is required to better understand the underlying mechanisms by which behavioral experiences regulate oligodendrocyte lineage cells, this exciting and newly emerging field has already revealed that oligodendrocytes and their progenitors are highly responsive to behavioral experiences and suggest the existence of a complex network of reciprocal interactions among oligodendrocyte lineage development, behavioral experiences, and brain function. Achieving a better understanding of these relationships may have profound implications for human health, and in particular, for our understanding of changes in brain function that occur in response to experiences. This article is part of the Special Issue entitled 'Oligodendrocytes in Health and Disease'.

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Abnormal fatty acid composition in the frontopolar cortex of patients with affective disorders

Cited by 30 publications

References 38 publications

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

Social Function and Frontopolar Activation during a Cognitive Task in Patients with Bipolar Disorder

The impact of chronic stress on the rat brain lipidome

Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity

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