Abnormal expression of liver autophagy and apoptosis-related mRNA in fatty liver haemorrhagic syndrome and improvement function of resveratrol in laying hens

Wang, Xiaoyu; Xing, Chenghong; Yang, Fan; Zhou, Sihui; Li, Guyue; Zhang, Caiying; Hu, Guoliang

doi:10.1080/03079457.2019.1698712

Cited by 16 publications

(15 citation statements)

References 43 publications

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“…The modulation of autophagy by resveratrol has been intensively investigated in the last decades [150,[304][305][306][307][308]. In the recent study, Gong and Xia showed that treatment melanoma cells with resveratrol led to the upregulation of proteins associated with autophagy (Beclin 1 and microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/I), while the p62 expression was downregulated [309].…”

Section: Modulation Of Autophagy and Apoptosis By Polyphenolsmentioning

confidence: 99%

Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

et al. 2020

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It has been thought that caloric restriction favors longevity and healthy aging where autophagy plays a vital role. However, autophagy decreases during aging and that can lead to the development of aging-associated diseases such as cancer, diabetes, neurodegeneration, etc. It was shown that autophagy can be induced by mechanical or chemical stress. In this regard, various pharmacological compounds were proposed, including natural polyphenols. Apart from the ability to induce autophagy, polyphenols, such as resveratrol, are capable of modulating the expression of pro- and anti-apoptotic factors, neutralizing free radical species, affecting mitochondrial functions, chelating redox-active transition metal ions, and preventing protein aggregation. Moreover, polyphenols have advantages compared to chemical inducers of autophagy due to their intrinsic natural bio-compatibility and safety. In this context, polyphenols can be considered as a potential therapeutic tool for healthy aging either as a part of a diet or as separate compounds (supplements). This review discusses the epigenetic aspect and the underlying molecular mechanism of polyphenols as an anti-aging remedy. In addition, the recent advances of studies on NAD-dependent deacetylase sirtuin-1 (SIRT1) regulation of autophagy, the role of senescence-associated secretory phenotype (SASP) in cells senescence and their regulation by polyphenols have been highlighted as well. Apart from that, the review also revised the latest information on how polyphenols can help to improve mitochondrial function and modulate apoptosis (programmed cell death).

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Section: Modulation Of Autophagy and Apoptosis By Polyphenolsmentioning

confidence: 99%

Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

et al. 2020

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show abstract

“…Also, OS induced inflammation (indicated by higher mRNA expression of pro-inflammatory cytokine, such as IL-1β, IL-6 , and TNF-α) and its upstreaming nuclear factor NF-κB ), decreased the villus height and antioxidant capacities of small intestine, as demonstrated by lower activities of antioxidant enzymes, SOD, GSH-Px, and T-AOC, and higher corresponding levels of MDA. Wang et al., 2020a also reported that layers exposed to high stocking density stress also led to deceases in villus height of small intestine. RV has been evident to restrain oxidative stress and alleviate inflammatory responses in a rat model of polycystic ovary syndrome ( Sadi et al., 2015 ).…”

Section: Discussionmentioning

confidence: 92%

Dietary resveratrol improved production performance, egg quality, and intestinal health of laying hens under oxidative stress

et al. 2022

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“…Too high or too low energy-to-protein ratios will cause FLHS in laying hens. For laying hens whose body weight exceeds the standard, the objective of preventing FLHS can be achieved by restricting feeding or reducing dietary energy (Wang et al 2020).…”

Section: Adjustment Of Energy-to-protein Ratiosmentioning

confidence: 99%

Pathogenesis and Nutritional Regulation of Fatty Liver Hemorrhage Syndrome in Laying Hens

2022

Int J Vet Sci

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Abnormal expression of liver autophagy and apoptosis-related mRNA in fatty liver haemorrhagic syndrome and improvement function of resveratrol in laying hens

Cited by 16 publications

References 43 publications

Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research

Dietary resveratrol improved production performance, egg quality, and intestinal health of laying hens under oxidative stress

Pathogenesis and Nutritional Regulation of Fatty Liver Hemorrhage Syndrome in Laying Hens

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