Abnormal expression of interleukin-6 is associated with epidermal alternations in localized scleroderma

Zhu, Xiaodong; Jiang, Liuyiqi; Zhong, Qian; Kong, Xiangzhen; Zhang, Rui; Zhu, Lingxian; Liu, Qingmei; Wu, Wenyu; Tan, Yimei; Wang, Jiucun; Xia, Jingjing

doi:10.1007/s10067-022-06127-w

Cited by 3 publications

(5 citation statements)

References 42 publications

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“…55,56 To sum up, both water loss and skin fibrosis caused by scleroderma can lead to a decrease in skin dielectric properties. 41,42,57 Therefore, the results of the decrease in the dielectric properties of skin caused by scleroderma shown in this paper can be verified by the conclusions of previous studies involving the relationship between the pathological processes related to scleroderma and dielectric properties.…”

Section: Discussionsupporting

confidence: 85%

“…The studies have shown that the bound water in the skin tightly adheres to the collagen surface, and the altered protein content of the skin in scleroderma lesions causes changes in the water content of the skin 36–40 . In addition, the skin moisture will decrease due to the increased transdermal water loss and decreased hydration of scleroderma skin 41,42 . The above‐mentioned previous studies indicate indirectly or directly that the scleroderma process involves the change of water content, which leads to changes in the dielectric properties of the skin that are closely related to the water content of the skin.…”

Section: Introductionmentioning

confidence: 97%

“…[36][37][38][39][40] In addition, the skin moisture will decrease due to the increased transdermal water loss and decreased hydration of scleroderma skin. 41,42 The above-mentioned previous studies indicate indirectly or directly that the scleroderma process involves the change of water content, which leads to changes in the dielectric properties of the skin that are closely related to the water content of the skin. Therefore, MITAM has the potential to probe the difference between the isolated skin of scleroderma mice and that of normal mice.…”

Section: Introductionmentioning

confidence: 98%

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Microwave‐induced thermoacoustic microscopy based on short‐pulse microwave and high‐frequency point‐focused ultrasonic transducer

et al. 2023

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BackgroundAs an emerging hybrid imaging modality, microwave‐induced thermoacoustic imaging (MITAI) provides high contrast and deep tissue penetration, and has been extensively applied in cancer diagnosis, arthritis detection, and brain research. However, the previous studies had a limited spatial resolution of about 0.45–1.5 mm.PurposeHere, we describe a microwave‐induced thermoacoustic microscopy (MITAM) system to help overcome the resolution limitation of current MITAI to image more subtle tissue features. On this basis, this paper applies MITAM to the thin skin and to demonstrate the potential of MITAM in detecting scleroderma.MethodsTo achieve high resolution, short pulse width microwave (pulse width: 70 ns) and high‐frequency ultrasonic point‐focused transducer (center frequency: 25 MHz) were used to build the MITAM system. Two parallel copper wires with a diameter of 90 μm in the X/Y plane and Y/Z plane were imaged to estimate X/Y/Z resolution. Nine Balb/c mice were randomly divided into three groups and injected with different concentrations of bleomycin to induce scleroderma models. Their ex vivo skins were then imaged by our MITAM system. Visual observations were performed on the 3‐dimensional skins MITAM images. And the mean value, Standard deviation, quartile distance, and signal‐to‐noise ratio were calculated to verify the results of the qualitative observations. Hematoxylin‐Eosin (HE) and Masson staining were used to validate the findings of the MITAM.ResultsThe thickness of each imaged skin was measured to be about 450 μm. As an organ composed of multiple layers of tissues, the skin needs to be imaged at high resolution for the detection of related diseases. The results obtained showed that the improved resolution (68 μm in the Z‐axis and 135 μm in the X‐axis/Y‐axis) of MITAM over conventional MITAI allowed us to differentiate scleroderma skins from normal skins and to identify the severity of scleroderma skins, consistent with the pathological findings of these skins.ConclusionsThe preliminary results obtained indicate that the MITAM can relieve the resolution limitation of traditional MITAI and has the potential to detection scleroderma. However, the transmission‐type MITAM mentioned in this paper is difficult to image in vivo due to the narrow area between the antenna and the transducer. In the future, a reflective scanning MITAM will be constructed to detect scleroderma in vivo.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

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Microwave‐induced thermoacoustic microscopy based on short‐pulse microwave and high‐frequency point‐focused ultrasonic transducer

et al. 2023

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“…Psoriatic pathogenesis is almost completely blocked in mice deficient for IL‐23 or the IL‐17 receptor, demonstrating the significance of the IL‐23/IL‐17 axis 15 . Abnormal production of pro‐inflammatory cytokines is the driver of many inflammatory skin diseases, 17–19 which allows their use as direct disease models. Injection of the pro‐inflammatory cytokine IL‐23 directly into mouse dermis leads to the activation of Th17 cells and the development of psoriasis 20 and is used as another mouse model for psoriasis 17 .…”

Section: Discussionmentioning

confidence: 99%

The opposite effect of tapinarof between IMQ and IL‐23 induced psoriasis mouse models

Zhu

Han

Tian

et al. 2023

Experimental Dermatology

Self Cite

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Tapinarof is an aryl hydrocarbon receptor (AHR) ligand which is used to treat plaque psoriasis in adults. However, the underlying mechanism is not yet fully understood. In this study, we applied two of the most studied psoriasis mouse models: topical application of imiquimod (IMQ) and subcutaneous injection of IL‐23. Although both models successfully induced psoriasis‐like lesions in mice, tapinarof had a completely opposite effect on the two models. Tapinarof decreased the expression of multiple essential cytokines involved in the pathological IL‐23/IL‐17/IL‐22 axis and ameliorated IMQ‐induced psoriatic dermatitis, inhibiting keratinocyte proliferation and abnormal differentiation. However, in the IL‐23‐injection‐model, tapinarof instead aggravated the disease. Here, tapinarof increased epidermal thickness and differentiated epidermal dysplasia in mice. Our data suggest that tapinarof may have different effects on varied types of psoriasis.

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“…The increase of these cytokines was an immediate response to SC permeability impairment, increased TEWL, and decreased SC hydration [26]. Moreover, IL-6 cytokine has been indicated in a wide range of inflammatory conditions, especially those affecting the skin due to abnormal epidermal skin barriers, thickening of the epidermis, and promoting dryness [27]. The release of inflammatory cytokines could activate mast cells and encourage the production of histamines and MMP-1 that caused the breakdown of skin collagen type 1 and contributed to skin dryness [28].…”

Section: Preventive Effect Of Cloud Ear Mushroom Extract Against Infl...mentioning

confidence: 99%

Multifunctional Biological Properties and Topical Film Forming Spray Base on Auricularia polytricha as a Natural Polysaccharide Containing Brown Agaricus bisporus Extract for Skin Hydration

Nitthikan,

Leelapornpisid,

Naksuriya

et al. 2023

Cosmetics

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Mushrooms are edible fungi containing valuable nutrients. They provide attractive bio-active properties, which have confirmed anti-oxidants, anti-aging, and anti-inflammatory properties. Mushrooms possess abundant natural polymers affecting skin hydration and acting as moisturizers supporting skin barrier function. In this study, cloud ear mushroom (Auricularia polytricha) water extract (CW) was produced as a natural polymer to evaluate a new film-forming spray (FFS) containing CW to increase skin hydration and protect transepidermal water loss. CW contained polysaccharides as 748.2 ± 0.02 mg glucose/g extract. CW significantly inhibited the secretion of IL-6 and TNF-α and enhanced skin hydration by increasing aquaporin-3 (AQP3) and filaggrin (FLG) in HaCaT cells. The FFS was formulated using CW, sodium polystyrene sulfonate, and glycerin. The selected formulation contained brown Agaricus bisporus (BE-FFS) evaluated physical appearance, spray angle, spray pattern, and in vitro skin permeation. The BE-FFS has a transparent thin film with suitable occlusive properties, drying time, and physical appearance. Afterward, in vitro skin permeation and human hydration property studies presented the long-lasting effects and provided safety and hydration potential after 4 weeks of use. Overall, all results indicate that the BE-FFS is a natural film-forming spray for skin hydration improvement.

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Abnormal expression of interleukin-6 is associated with epidermal alternations in localized scleroderma

Cited by 3 publications

References 42 publications

Microwave‐induced thermoacoustic microscopy based on short‐pulse microwave and high‐frequency point‐focused ultrasonic transducer

Microwave‐induced thermoacoustic microscopy based on short‐pulse microwave and high‐frequency point‐focused ultrasonic transducer

The opposite effect of tapinarof between IMQ and IL‐23 induced psoriasis mouse models

Multifunctional Biological Properties and Topical Film Forming Spray Base on Auricularia polytricha as a Natural Polysaccharide Containing Brown Agaricus bisporus Extract for Skin Hydration

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